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DNA damage response and neuroprotection
Frontiers in Bioscience, 2008The protection of genomic integrity is a major challenge for living cells that are continuously exposed to endogenous and environmental DNA-damaging insults. To cope with the consequences of DNA lesions which interfere with essential DNA-dependent processes including transcription and replication, cells are equipped with an efficient defense mechanism ...
Inna I, Kruman, Elena I, Schwartz
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Accolades for the DNA Damage Response
New England Journal of Medicine, 2015Given the importance to human health of the DNA damage response, it's not surprising that the Lasker Award for Basic Medical Research is being given to two scientists who have elucidated this response: Evelyn Witkin for work in bacteria and Stephen Elledge for work in eukaryotes.
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Cellular responses to DNA damage
Current Opinion in Cell Biology, 1998The exposure of cells to DNA damage inducers triggers a wide range of cellular responses including an alteration in gene expression, a delay in cell-cycle progression and the stimulation of DNA repair. In multicellular organisms, DNA damage can also activate programmed cell death.
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The p53 response to DNA damage
DNA Repair, 2004The p53 tumour suppressor protein is a highly potent transcription factor which, under normal circumstances, is maintained at low levels through the action of MDM2, an E3 ubiquitin ligase which directs p53 ubiquitylation and degradation. Expression of the mdm2 gene is stimulated by p53 and this reciprocal relationship forms the basis of a negative ...
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ATM and Cellular Response to DNA Damage
2006Most human cancers display a myriad of genetic changes, a characteristic often attributed to genome instability. Cytogenetic studies have long identified chromosomal aberrations as a hallmark of human tumours, but the causes and consequences of genomic defects in tumours still remain to be fully understood. In particular, the role of genome instability
Lavin, Martin F. +6 more
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The DNA damage response during DNA replication
Current Opinion in Cell Biology, 2005Eukaryotic chromosome replication is mediated by multiple replicons and is coordinated with sister chromatid cohesion, DNA recombination, transcription and cell cycle progression. Replication forks stall or collapse at DNA lesions or problematic genomic regions, and these events have often been associated with recombination and chromosomal ...
M. Foiani, D. Branzei
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2014
This chapter reviews the current knowledge about the mechanism of the LexA/RecA regulated response and its output in Escherichia coli, stressing newly emerging areas such as regulation of RecA filament formation and management of specialized DNA repair polymerases. It also talks about the SOS response in other bacterial species and its implications for
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This chapter reviews the current knowledge about the mechanism of the LexA/RecA regulated response and its output in Escherichia coli, stressing newly emerging areas such as regulation of RecA filament formation and management of specialized DNA repair polymerases. It also talks about the SOS response in other bacterial species and its implications for
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Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
Nature, 2021Juan Garaycoechea +2 more
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Checkpoint response to DNA damage
DNA Repair, 2009M. Muzi-Falconi, J. Petrini
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The DNA damage response to transcription stress
Nature Reviews Molecular Cell Biology, 2019Jürgen Marteijn +2 more
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