Results 81 to 90 of about 1,287,961 (310)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

The Histone-Fold Protein CHRAC14 Influences Chromatin Composition in Response to DNA Damage

Cell Reports, 2014
Summary: Chromatin reorganization and the incorporation of specific histone modifications during DNA damage response are essential steps for the successful repair of any DNA lesion.
Veena Mathew, Anne-Laure Pauleau, Natascha Steffen, Andrea Bergner, Peter B. Becker, Sylvia Erhardt   +5 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Interplay of space radiation and microgravity in DNA damage and DNA damage response

npj Microgravity, 2017
In space, multiple unique environmental factors, particularly microgravity and space radiation, pose constant threat to the DNA integrity of living organisms.
María Moreno-Villanueva, Michael Wong, Tao Lu, Ye Zhang, Honglu Wu   +4 more
doaj   +1 more source

Preserving genome integrity and function: the DNA damage response and histone modifications

Critical reviews in biochemistry and molecular biology, 2019
Modulation of chromatin templates in response to cellular cues, including DNA damage, relies heavily on the post-translation modification of histones.
Jae Jin Kim, S. Lee, K. Miller
semanticscholar   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

P1327: INHIBITING TELOMERIC DNA DAMAGE RESPONSE AS A NEW THERAPEUTIC STRATEGY TO REJUVENATE THE AGEING HEMATOPOIETIC SYSTEM

HemaSphere, 2023
Alessia Oppezzo, Sara Sepe, Francesca Rossiello, Anastasia Conti, Eugenia Marinelli, Sara Boggio, Alessia DI Lillo, Ilaria Rosso, Sara Tavella, Valentina Matti, Giada Cicio, Valeria Cancila, Alexandra Mancheno-Ferris, Giorgio Bertolazzi, Fabio Iannelli, Raffaella DI Micco, Claudio Tripodo, Fabrizio D’adda DI Fagagna   +17 more
doaj   +1 more source

Correction: Corrigendum: DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs

Nature Communications, 2017
Nature Communications 8: Article number: 13980 (2017); Published: 27 February 2017; Updated: 13 April 2017 In Supplementary Fig. 3d, the two columns of DAPI images associated with pATM and pS/TQ images were inadvertently swapped.
Francesca Rossiello, Julio Aguado, Sara Sepe, Fabio Iannelli, Quan Nguyen, Sethuramasundaram Pitchiaya, Piero Carninci, Fabrizio d’Adda di Fagagna   +7 more
doaj   +1 more source

Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease

Cell Death and Disease, 2018
The involvement of DNA damage and repair in aging processes is well established. Aging is an unequivocal risk factor for chronic neurodegenerative diseases, underscoring the relevance of investigations into the role that DNA alterations may have in the ...
C. Milanese, S. Cerri, Ayse Ulusoy, S. Gornati, Audrey Plat, Sylvia Gabriels, F. Blandini, D. D. Di Monte, J. Hoeijmakers, P. Mastroberardino   +9 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source