Results 121 to 130 of about 106,021 (225)

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Targeting the DNA damage response in cancer

MedComm
DNA damage response (DDR) pathway is the coordinated cellular network dealing with the identification, signaling, and repair of DNA damage. It tightly regulates cell cycle progression and promotes DNA repair to minimize DNA damage to daughter cells.
G. Federica, Chiappalone Michela, Damia Giovanna   +2 more
semanticscholar   +1 more source

CTCF/cohesin-binding sites are susceptible to replication-associated DNA damage and genomic instability in cancer cells

iScience
Summary: CTCF/cohesin-binding sites (CBSs) at the chromatin-loop anchors and topologically associating domains are frequently mutated in cancer; however, the underlying molecular mechanisms remain unclear. Here, we investigate whether CTCF and cohesin co-
Elangoli Ebrahimkutty Faseela, Dimple Notani, Radhakrishnan Sabarinathan   +2 more
doaj   +1 more source

Posttranscriptional regulation of gene expression – adding another layer of complexity to the DNA damage response

Frontiers in Genetics, 2012
In response to DNA damage, cells activate a complex, kinase-based signaling network to arrest the cell cycle and allow time for DNA repair, or, if the extend of damage is beyond repair capacity, induce apoptosis.
Jorge eBoucas, Katja eHöpker, Shuhua eChen, Grit Sophie Herter-Sprie, Mladen eJokic, Arina eRiabinska, Hans Christian Reinhardt   +6 more
doaj   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

Response to DNA damage: why do we need to focus on protein phosphatases?

Frontiers in Oncology, 2013
Eukaryotic cells are continuously threatened by unavoidable errors during normal DNA replication or various sources of genotoxic stresses that cause DNA damage or stalled replication.
Midori eShimada, Makoto eNakanishi
doaj   +1 more source

Clonal Hematopoiesis and CAR T Cell Therapy: From Biological Crosstalk to Clinical Implications

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Clonal hematopoiesis (CH) is increasingly recognized as a significant biological phenomenon in aging and cancer, marked by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations in genes associated with myeloid neoplasms.
Wei Du, Shunsuke Koga, Guang Yang, Saar Gill, Adam Bagg   +4 more
wiley   +1 more source

R‐Loops Mediated Odontogenic Differentiation of hDPSCs by Activating the cGAS‐STING Pathway Under Inflammatory Microenvironment

Oral Diseases, EarlyView.
ABSTRACT Background R‐Loops are three‐stranded DNA/RNA hybrids implicated in immune responses. Their role in mesenchymal stem cell differentiation, particularly in dental pulp regeneration under inflammation, remains unclear. Methods Rat pulpo‐dentinal complex (PDC) injury models and LPS‐stimulated human dental pulp stem cells (hDPSCs) were used.
Yun Yang, Yiqing Wang, Yating Miao, Zhipu Luo, Lin Niu, Ruirui Liu   +5 more
wiley   +1 more source

Zeocin-induced DNA damage response in barley and its dependence on ATR

Scientific Reports
DNA damage response (DDR) is an essential mechanism by which living organisms maintain their genomic stability. In plants, DDR is important also for normal growth and yield.
Jovanka Vladejić, Martin Kovacik, Jana Zwyrtková, Miriam Szurman-Zubrzycka, Jaroslav Doležel, Ales Pecinka   +5 more
doaj   +1 more source