Results 121 to 130 of about 24,752 (187)

Genetic Variants of BMI1 (rs1042059 and rs11591377) and Their Potential Role in Leukemia Susceptibility: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Leukemia is a heterogeneous group of hematologic malignancies influenced by both genetic and environmental factors. The B‐cell‐specific Moloney murine leukemia virus integration site 1 (BMI1) gene, a key regulator of hematopoietic stem cell self‐renewal and oncogenesis, has been implicated in leukemia pathogenesis.
Mojtaba Aghaei, Niloufar Afrough, Mohammad Ali Jalali Far   +2 more
wiley   +1 more source

Targeting the DNA damage response (DDR) of cancer cells with natural compounds derived from Panax ginseng and other plants. [PDF]

J Ginseng Res
Choi S, Shin M, Kim WY.
europepmc   +1 more source

Lutein Influences Cisplatin Sensitivity Through Differential Regulation of DNA Damage Response Genes in Breast Cancer Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
Simultaneous treatment with lutein and cisplatin enhances oxidative DNA damage in breast cancer cells (MCF‐7 and MDA‐MB‐231) and promotes apoptosis specifically in MDA‐MB‐231 cells, while modulating DNA repair and damage response genes across cell types. Additionally, the combination increases cytotoxicity in HUVECs.
Funda Demirtas Korkmaz, Zekeriya Duzgun, Aysegul Cebi   +2 more
wiley   +1 more source

Treatment of Sulfur Mustard Corneal Injury by Augmenting the DNA Damage Response (DDR): A Novel Approach. [PDF]

J Pharmacol Exp Ther
Shalwitz R, Day T, Ruehlmann AK, Julio L, Gordon S, Vandeuren A, Nelson M, Lyman M, Kelly K, Altvater A, Ondeck C, O'Brien S, Hamilton T, Hanson RL, Wayman K, Miller A, Shalwitz I, Batchelor E, McNutt P.   +18 more
europepmc   +1 more source

Immune Evasion in Ovarian Cancer Peritoneal Metastasis: Mechanisms and Biomarker‐Guided Therapeutic Matching

Journal of Cellular Physiology, Volume 241, Issue 6, June 2026.
This graphical abstract summarizes the major immune‐evasion mechanisms that limit immunotherapy efficacy in ovarian cancer peritoneal metastasis. Peritoneal dissemination is shaped by impaired antigen visibility, coordinated immune‐evasion modules within ascites and multicellular spheroids, checkpoint‐driven T‐cell exhaustion, suppressive tumor ...
Xiaodong Wang, Junjie Wang, Di Xiong, Songli Cui, Qianqian Wang, Yiping Huang, Gouping Ding, Yixuan Tang, Yeqian Feng   +8 more
wiley   +1 more source

CDK7 as a Potential Exploratory Biomarker for Distinguishing Acute Myocardial

Clinical Cardiology, Volume 49, Issue 6, June 2026.
Awais Mehmood, Romesa Tahir
wiley   +1 more source

Host–Pathogen Dual Targeting With Repurposed Drugs Identifies a Synergistic Therapy for Intracellular Staphylococcus aureus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres, Helena Á. Ferrero, Pablo Castañera, Jesús Llano‐Verdeja, Sergio Fernández‐Martínez, Amanda Herrero‐González, Farzaneh Javadimarand, Roberto López, Jesús F. Aparicio, Andrew M. Edwards, Volker Behrends, Luis M. Mateos, Álvaro Mourenza, Michal Letek   +13 more
wiley   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Ribosomal Proteins in Cell Biology and Cancer

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The functions of ribosomal proteins (RPs) extend beyond the conventional translation process, as they also regulate gene expression, stress responses, and disease progression. Dysregulation of RPs contributes to the onset and progression of various diseases, including cancer and ribosomopathies, underscoring their dual role as critical disease ...
Ao Zhang, Zeguang Sun, Xinyang Song, Xikun Zhou, Jing Li   +4 more
wiley   +1 more source