Results 121 to 130 of about 7,534,152 (213)

The roles of YBX1 in intracellular and intercellular DNA damage response

RNA-dependent DNA damage response (DDR) is an emerging field, focusing on the influence of RNA species on DNA repair. A multifunctional RNA and DNA-binding protein, YBX1 is under study as a player in RNA-dependent DDR which localises to DNA breaks and ...
Shaw, Annabelle
core   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

ATM-dependent and -independent Chk2 phosphorylation, activation and cell cycle regulation in response to DNA damage

, 2000
The highly conserved Chk2 kinase has a key role in delaying the cell cycle progression in response to DNA damage in eukaryotic cells. Using human lymphoblastoid and fibroblast cell lines we have characterized the time-dependent Chk2 phosphorylation ...
G. Buscemi, M. Nakanishi, S. Mizutani, L. Chessa, L. Zannini, D. Masnada, D. Delia, F. Miccichè, C. Savio   +8 more
core   +2 more sources

Dynamic properties of enhancer and promoter during DNA damage in hepatocellular carcinoma

iScience
Summary: DNA damage is a critical factor contributing to tumorigenesis, however, the dynamic changes in multi-omics signatures of enhancers and promoters during the DNA damage response (DDR) remain poorly understood. In this study, we discovered that the
Jinyuan Zhang, Tianyu Ma, Longjun Xian, Zhiyun Guo   +3 more
doaj   +1 more source

R‐Loops Mediated Odontogenic Differentiation of hDPSCs by Activating the cGAS‐STING Pathway Under Inflammatory Microenvironment

Oral Diseases, EarlyView.
ABSTRACT Background R‐Loops are three‐stranded DNA/RNA hybrids implicated in immune responses. Their role in mesenchymal stem cell differentiation, particularly in dental pulp regeneration under inflammation, remains unclear. Methods Rat pulpo‐dentinal complex (PDC) injury models and LPS‐stimulated human dental pulp stem cells (hDPSCs) were used.
Yun Yang, Yiqing Wang, Yating Miao, Zhipu Luo, Lin Niu, Ruirui Liu   +5 more
wiley   +1 more source

Chromatin Remodelling Complexes in Plant Adaptation to Abiotic Stress: Mechanisms and Perspectives

Plant, Cell &Environment, EarlyView.
ABSTRACT As sessile organisms, plants have evolved elaborate epigenetic regulatory networks to adapt to a wide range of abiotic stress. Chromatin remodelling is a core epigenetic regulatory mechanism that refers to the process by which chromatin remodelling complexes mediate dynamic changes in chromatin spatial conformation and DNA accessibility ...
Xiuxiu Zhang, Yueran Zhang, Jiang Li
wiley   +1 more source

Root surface biomodification in periodontal therapy: Biological rationale and clinical applications

Periodontology 2000, EarlyView.
Abstract Regenerative periodontal therapy aims to form new cementum, periodontal ligament, and alveolar bone, all sealed by gingival tissue. The root surface acts as the wound margin during this regeneration process. Root surface biomodification (root conditioning/root decontamination), therefore, seems instrumental in promoting surface decontamination
Muhammad H. A. Saleh, Debora R. Dias, Andrea Ravida, Hom‐Lay Wang   +3 more
wiley   +1 more source

Advanced imaging and multi‐omics to characterize cardiomyocyte ageing and its electrocardiographic imprint in PKP2 arrhythmogenic cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend We used a murine model of cardiomyocyte‐specific conditional knockout of plakophilin 2 (PKP2cKO, middle panel). Using advanced imaging technology, we unveiled distinct hallmarks of premature ageing in PKP2cKO cardiomyocytes, including DNA damage and loss of repressed heterochromatin at the nuclear periphery, and mitochondrial ...
Giorgia Bertoli, Kavya Phadke, Alessandro Cospito, Xianming Lin, Marina Cerrone, Joanna Abi Rizk, Michael Cammer, Yan Deng, Joseph Sall, Mingliang Zhang, Feng‐Xia Liang, Irene de Lázaro, Mario Delmar   +12 more
wiley   +1 more source

Evaluation of Mutation Risk Using Patient‐Derived Organoids in Patients With Lynch Syndrome

International Journal of Cancer, Volume 159, Issue 10, Page 2585-2594, 15 November 2026.
ABSTRACT Lynch syndrome (LS) is a hereditary cancer predisposition syndrome caused by germline mutation of DNA mismatch repair (MMR) genes, most notably associated with colorectal cancer. Although LS patients face high risk of CRC, risk can vary even among those with the same pathogenic MMR germline mutations. We suggest a functional assay platform for
Youmi Shin, Dong Keon Kim, Yoojeong Seo, Hyeon Hee Lee, Jihye Park, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Jongwon Oh, Sanghoo Lee, Tae Il Kim   +10 more
wiley   +1 more source

DNA damage accumulation and response in Down syndrome cell model systems

, 2012
DNA damage may significantly contribute to the etiology of several human diseases, including tumors and neurological disorders. In particular, DNA damage has been associated with many of the latter pathologies, such as Alzheimer disease (AD), and ...
Tillhon M, Lanni C, Necchi D, Prosperi E, Scherini E   +4 more
core