Results 131 to 140 of about 106,021 (225)

Chromatin Remodelling Complexes in Plant Adaptation to Abiotic Stress: Mechanisms and Perspectives

Plant, Cell &Environment, EarlyView.
ABSTRACT As sessile organisms, plants have evolved elaborate epigenetic regulatory networks to adapt to a wide range of abiotic stress. Chromatin remodelling is a core epigenetic regulatory mechanism that refers to the process by which chromatin remodelling complexes mediate dynamic changes in chromatin spatial conformation and DNA accessibility ...
Xiuxiu Zhang, Yueran Zhang, Jiang Li
wiley   +1 more source

Root surface biomodification in periodontal therapy: Biological rationale and clinical applications

Periodontology 2000, EarlyView.
Abstract Regenerative periodontal therapy aims to form new cementum, periodontal ligament, and alveolar bone, all sealed by gingival tissue. The root surface acts as the wound margin during this regeneration process. Root surface biomodification (root conditioning/root decontamination), therefore, seems instrumental in promoting surface decontamination
Muhammad H. A. Saleh, Debora R. Dias, Andrea Ravida, Hom‐Lay Wang   +3 more
wiley   +1 more source

Low‐dose X‐ray radiation induces an adaptive response: A potential countermeasure to galactic cosmic radiation exposure

Experimental Physiology, EarlyView.
Abstract Space exploration involves many dangers including galactic cosmic radiation (GCR). This class of radiation includes high‐energy protons and heavy ionizing ions. NASA has defined GCR as a carcinogenic risk for long‐duration space missions. To date, no clear strategy has been developed to counter chronic GCR exposure.
Siena Edwards, Jessica Adams, Anastasia Tchernikov, John G. Edwards   +3 more
wiley   +1 more source

FBXW7-mediated CHK2 regulation modulates DNA damage response and cellular stability in Huntington’s disease

Cell Death Discovery
DNA damage activates the DNA damage response (DDR) machinery. However, aging impairs DDR in neurons, thereby increasing susceptibility to neurodegenerative diseases, such as Huntington’s disease (HD).
Tae Eun Kang, Yu Min Lee, Seung Ho Choi, KyoungJoo Cho   +3 more
doaj   +1 more source

DNA damage responses in HCMV infection: emerging mechanisms and outstanding questions

Journal of Virology
The cellular DNA damage response (DDR) is essential for maintaining genome integrity in the face of exogenous assault, as well as errors and breaks introduced during DNA replication.
Mamata Savanagouder, Pierce Longmire, Ahmed Hassan, David McKinzey, Rachel Dansereau, Giovanni Bosco, Felicia Goodrum   +6 more
doaj   +1 more source

Somatic NGS Analysis of DNA Damage Response (DDR) Genes ATM, MRE11A, RAD50, NBN, and ATR in Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemo-Radiotherapy. [PDF]

Biomedicines, 2022
Montori A, Germani A, Ferri M, Milano A, Ranalli TV, Piane M, Pilozzi E.   +6 more
europepmc   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

“A DNA Damage Response (DDR) –independent Role for the Ataxia-Telangiectasia Mutated (ATM) Gene Product" [PDF]

, 2010
Ataxia-Telangiectasia (A-T) is a recessive hereditary syndrome characterized by cerebellar degeneration, telangiectasia, precocious aging, immunodeficiency, cancer predisposition and insulin-resistant diabetes. A-T is caused by defects in Ataxia-Telagiectasia Mutated (Atm) gene.
openaire   +1 more source

Functional characterization of novel DNA Damage Response (DDR) genes

, 2019
Our cells have evolved to deal with thousands of DNA damage events that occur every day, activating the DNA Damage Response (DDR) network. DDR is a complex mechanism that leads to cell-cycle arrest, regulation of DNA replication, repair or bypass of DNA damage.
openaire   +1 more source

Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights

Aging Cell, Volume 25, Issue 8, August 2026.
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley   +1 more source