Results 21 to 30 of about 60,468 (238)
An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis [corrected]. [PDF]
PLoS Genetics, 2015 Active DNA demethylation in plants occurs through base excision repair, beginning with removal of methylated cytosine by the ROS1/DME subfamily of 5-methylcytosine DNA glycosylases.
Yan Li +8 more
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DNA Methylation and Demethylation in Arabidopsis [PDF]
The Arabidopsis Book, 2008 Writing about a biological subject based on one species can limit the scope of the discussion, but in the case of DNA methylation and Arabidopsis, the restriction is entirely appropriate. Unlike many other popular model organisms, Arabidopsis has retained and embellished a multi-layered methylation system that contributes to gene and transposon ...
Mary, Gehring, Steven, Henikoff
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DNA Methylation and Demethylation in Mammals [PDF]
Journal of Biological Chemistry, 2011 Cell type-specific DNA methylation patterns are established during mammalian development and maintained in adult somatic cells. Understanding how these patterns of 5-methylcytosine are established and maintained requires the elucidation of mechanisms for both DNA methylation and demethylation.
Chen, Zhao-xia, Riggs, Arthur D.
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Blood Advances, 2017 : RUNX1 is an essential master transcription factor in hematopoietic development and plays important roles in immune functions. Although the gene regulatory mechanism of RUNX1 has been characterized extensively, the epigenetic role of RUNX1 remains ...
Takahiro Suzuki +8 more
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Rad50 mediates DNA demethylation to establish pluripotent reprogramming
Experimental and Molecular Medicine, 2020 Regenerative medicine: Protein boosts stem cell generation process Heightened expression of a DNA repair protein improves efficiency when generating induced pluripotent stem cells (iPSCs) for use in regenerative medicine.
Hanseul Park +2 more
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Nature Communications, 2021 Active DNA demethylation is required for sexual reproduction in plants, but the underlying mechanisms are unknown. Here, the authors show that the DNA glycosylases DEMETER and REPRESSOR OF SILENCING 1 enable the DNA demethylation-dependent activation of ...
Souraya Khouider +7 more
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GADD45A does not promote DNA demethylation.
PLoS Genetics, 2008 Although DNA methylation patterns in somatic cells are thought to be relatively stable, they undergo dramatic changes during embryonic development, gametogenesis, and during malignant transformation.
Seung-Gi Jin, Cai Guo, Gerd P Pfeifer
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Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation.
PLoS ONE, 2010 Gemcitabine is a cytotoxic cytidine analog, which is widely used in anti-cancer therapy. One mechanism by which gemcitabine acts is by inhibiting nucleotide excision repair (NER).
Andrea Schäfer +4 more
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Methylation-sensitive expression of a DNA demethylase gene serves as an epigenetic rheostat. [PDF]
PLoS Genetics, 2015 Genomes must balance active suppression of transposable elements (TEs) with the need to maintain gene expression. In Arabidopsis, euchromatic TEs are targeted by RNA-directed DNA methylation (RdDM).
Ben P Williams +3 more
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Epigenetics & Chromatin, 2017 Background DNA methylation is a fundamental epigenetic modification that is involved in many biological systems such as differentiation and disease. We and others recently showed that some transcription factors (TFs) are involved in the site-specific ...
Takahiro Suzuki +6 more
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