Results 11 to 20 of about 60,468 (238)
Proceedings of the National Academy of Sciences, 1999 Cytosine 5′ methylation of CpG dinucleotides within and around genes exerts a major influence on transcription in many plants and animals (1–3). DNA methylation can be causal for transcriptional silencing (4–5) and targets the machinery necessary to assemble specialized chromatin enriched in deacetylated histones (6–8).
A P, Wolffe, P L, Jones, P A, Wade
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DNA demethylation by DNA repair [PDF]
Trends in Genetics, 2009 Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process.
Gehring, Mary +2 more
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DNA Demethylation by TDG [PDF]
Epigenomics, 2012 DNA methylation has long been considered a very stable DNA modification in mammals that could only be removed by replication in the absence of remethylation - that is, by mere dilution of this epigenetic mark (so-called passive DNA demethylation). However, in recent years, a significant number of studies have revealed the existence of active processes ...
Shannon R, Dalton, Alfonso, Bellacosa
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Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells
Genome Biology, 2021 Background TET enzymes mediate DNA demethylation by oxidizing 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Since these oxidized methylcytosines (oxi-mCs) are not recognized by the
Atsushi Onodera +6 more
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DNA Demethylation Dynamics [PDF]
Cell, 2011 The discovery of cytosine hydroxymethylation (5hmC) suggested a simple means of demethylating DNA and activating genes. Further experiments, however, unearthed an unexpectedly complex process, entailing both passive and active mechanisms of DNA demethylation by the ten-eleven translocation (TET) and AID/APOBEC families of enzymes.
Bhutani, Nidhi +2 more
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Active DNA Demethylation in Plants [PDF]
International Journal of Molecular Sciences, 2019 Methylation of cytosine (5-meC) is a critical epigenetic modification in many eukaryotes, and genomic DNA methylation landscapes are dynamically regulated by opposed methylation and demethylation processes. Plants are unique in possessing a mechanism for active DNA demethylation involving DNA glycosylases that excise 5-meC and initiate its replacement ...
Jara Teresa Parrilla-Doblas +3 more
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The Influence of Hydroxylation on Maintaining CpG Methylation Patterns: A Hidden Markov Model Approach. [PDF]
PLoS Computational Biology, 2016 DNA methylation and demethylation are opposing processes that when in balance create stable patterns of epigenetic memory. The control of DNA methylation pattern formation by replication dependent and independent demethylation processes has been ...
Pascal Giehr +4 more
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Processive DNA demethylation via DNA deaminase-induced lesion resolution. [PDF]
PLoS ONE, 2014 Base modifications of cytosine are an important aspect of chromatin biology, as they can directly regulate gene expression, while DNA repair ensures that those modifications retain genome integrity. Here we characterize how cytosine DNA deaminase AID can
Don-Marc Franchini +8 more
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Reprogramming of the Hevea brasiliensis Epigenome and Transcriptome in Response to Cold Stress
Frontiers in Plant Science, 2022 Low temperature is a key factor limiting the rubber plantation extending to high latitude area. Previous work has shown that cold-induced DNA demethylation was coordinated with the expression of cold-responsive (COR) genes in Hevea brasiliensis.
Xiao Tang +5 more
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Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles. [PDF]
PLoS ONE, 2012 Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA methylation patterns controlling transcription and activity of Dnmt1.
Fabio Ciccarone +7 more
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