Results 31 to 40 of about 60,468 (238)
Nature Communications, 2021 The causal relationship between DNA demethylation and gene expression regulation has not yet been fully resolved. Here the authors develop a nuclease-dead Cas9 (dCas9) and gRNA site-specific targeting approach to physically block DNA methylation at ...
Daniel M. Sapozhnikov, Moshe Szyf
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Epigenetic Changes during Hepatic Stellate Cell Activation. [PDF]
PLoS ONE, 2015 Hepatic stellate cells (HSC), which can participate in liver regeneration and fibrogenesis, have recently been identified as liver-resident mesenchymal stem cells.
Silke Götze +3 more
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DEMETER plant DNA demethylase induces antiviral response by interferon signalling in animal cells
Scientific Reports, 2017 DNA methylation is a prominent epigenetic modification in plants and animals regulated by similar mechanisms but the process of DNA demethylation is profoundly different.
Young Geun Mok +3 more
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eLife, 2019 Base excision repair (BER) functions not only in the maintenance of genomic integrity but also in active DNA demethylation and epigenetic gene regulation.
Dandan Han +8 more
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Vitamin C Rescues in vitro Embryonic Development by Correcting Impaired Active DNA Demethylation
Frontiers in Cell and Developmental Biology, 2021 During preimplantation development, a wave of genome-wide DNA demethylation occurs to acquire a hypomethylated genome of the blastocyst. As an essential epigenomic event, postfertilization DNA demethylation is critical to establish full developmental ...
Meiqiang Chu +7 more
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Biologia Plantarum, 2016 Little is known about the contributions of DNA methylation/demethylation to plant aging and senescence. We used Arabidopsis thaliana to study how increasing age of an annual plant species influences DNA methylation.
Z. V. Ogneva +2 more
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Frontiers in Genetics, 2022 DNA methylation patterns in plants are dynamically shaped by the antagonistic actions of DNA methylation and demethylation pathways. Although the DNA methylation pathway has been well studied, the DNA demethylation pathway, however, are not fully ...
Xiangyu Wang +4 more
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Epigenetic Regulation of Genomic Stability by Vitamin C
Frontiers in Genetics, 2021 DNA methylation plays an important role in the maintenance of genomic stability. Ten-eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG -dependent dioxygenases that regulate DNA methylation levels by oxidizing 5-methylcystosine ...
John P. Brabson +6 more
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Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation [PDF]
IUCrJ, 2014 Iron(II) and 2-oxoglutarate (2OG)-dependent dioxygenases involved in histone and DNA/RNA demethylation convert the cosubstrate 2OG and oxygen to succinate and carbon dioxide, resulting in hydroxylation of the methyl group of the substrates and subsequent demethylation.
Cheng Dong +4 more
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DNA demethylation in erythroleukaemia cells
FEBS Letters, 1990 Despite a fall in the proportion of CGs methylated, evidence has not been obtained for significant demethylation of prelabelled DNA when mouse erythroleukaemia cells are induced to differentiate. There is, however, a delay in the methylation of the DNA that is synthesised in the early period of induction, leading to its undermethylation by 30–50% and ...
Adams, R.L.P., Hanley, A., Rinaldi, A.
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