Results 61 to 70 of about 60,468 (238)
No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos. [PDF]
PLoS ONE, 2014 The mechanisms responsible for active DNA demethylation remain elusive in Metazoa. A previous study that utilized zebrafish embryos provided a potent mechanism for active demethylation in which three proteins, AID, MBD4, and GADD45 are involved.
Nobuyoshi Shimoda +6 more
doaj +1 more source
Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing
Advanced Science, EarlyView.Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan +13 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2015 Gadd45-mediated DNA demethylation mechanisms have been implicated in the process of memory formation. However, the transcriptional mechanisms involved in the regulation of Gadd45 gene expression during memory formation remain unexplored.
Timothy J Jarome +4 more
doaj +1 more source
Reprogramming of fibroblast cells to totipotent state by DNA demethylation
Scientific Reports, 2023 Many attempts have been made to induce high-quality embryonic stem cells such as pluripotent stem cells and totipotent stem cells, but challenges remain to be overcome such as appropriate methods and sources.
Mohammad H. Ghazimoradi +4 more
doaj +1 more source
Advanced Science, EarlyView.This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei +18 more
wiley +1 more source
DNA demethylation is involved in nitric oxide-induced flowering in tomato
Journal of Integrative AgricultureFlowering is one of the most important phenological periods, as it determines the timing of fruit maturation and seed dispersal. To date, both nitric oxide (NO) and DNA demethylation have been reported to regulate flowering in plants.
Xuemei Hou +8 more
doaj +1 more source
Oxidative Demethylation of DNA
The FASEB Journal, 2007 Oxidative demethylation of DNA Non‐enzymatic methylation of DNA by alkylating agents such as MMS occurs at several sites, but not at the 5 position of cytosine. Instead, the main cytotoxic lesions are 3‐methyladenine, and in single‐stranded regions of DNA also 1‐methyladenine and 3‐methylcytosine.
Tomas Lindahl, Barbara Sedgwick
openaire +1 more source
Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Advanced NanoBiomed Research, EarlyView.Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells
Scientific Reports, 2018 Epigenetic modulation may underlie the progression of diabetic nephropathy (DN). Involvement of TGFB1 in mesangial fibrosis of DN led us to hypothesize that Tgfb1 DNA demethylation contributes to progression of DN.
Shigeyoshi Oba +9 more
doaj +1 more source
TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation
Epigenetics & Chromatin, 2022 Background Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been implicated in DNA demethylation due to its role in base excision repair. Recent evidence indicates a direct influence of PARP-
Anja Tolić +12 more
doaj +1 more source