Results 71 to 80 of about 60,603 (249)

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, EarlyView.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

Thinned young apple polyphenol prevents diabetic cardiomyopathy through promoting TET2-mediated active DNA demethylation in STZ-induced diabetic mice heart

Food Science and Human Wellness
Diabetic cardiomyopathy (DCM) refers diabetic patients develop cardiomyopathy characterized by cardiac systolic and diastolic dysfunction. Currently, no research has explored the role of ten-eleven translocation (TET)-mediated active DNA demethylation in
Run Liu, Zhongshi Qi, Liying Zhou, Jiacheng Fang, Shengjie Pei, Yanlei Yuan, Chunyan Tian, Yiding Zhang, Lei Chen, Duo Li   +9 more
doaj   +1 more source

TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation

Epigenetics & Chromatin, 2022
Background Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been implicated in DNA demethylation due to its role in base excision repair. Recent evidence indicates a direct influence of PARP-
Anja Tolić, Mirunalini Ravichandran, Jovana Rajić, Marija Đorđević, Miloš Đorđević, Svetlana Dinić, Nevena Grdović, Jelena Arambašić Jovanović, Mirjana Mihailović, Nataša Nestorović, Tomasz P. Jurkowski, Aleksandra S. Uskoković, Melita S. Vidaković   +12 more
doaj   +1 more source

A Pan‐Methylome Framework for Population‐Scale Bacterial Epigenomics

Advanced Science, EarlyView.
A scalable quantitative framework unlocks population‐level comparative epigenomics in bacteria. By transforming site‐level data into standardized traits, this approach reconstructs methylation‐informed phylogenies and defines the core epigenome.
Bin Ma, Huimin Gong, Ran Zhuo, Zaixiao Rao, Yanxi Wan, Mingyang Wang, Zahra Zeinalzadeh, Yuan Gao, Aohan Guan, Xinrun Li, Wanting Chen, Xiliang Wang, Yun Wan, Sihua Zhang, Yuncai Xiao, Qi Huang, Paul R. Langford, Xiangru Wang, Rui Zhou, Rui Luo, Hongbo Zhou, Chengliang Zhu, Hui Jin   +22 more
wiley   +1 more source

The level of active DNA demethylation compounds in leukocytes and urine samples as potential epigenetic biomarkers in breast cancer patients

Scientific Reports
The active DNA demethylation process, which involves TET proteins, can affect DNA methylation pattern. TET dependent demethylation results in DNA hypomethylation by oxidation 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) and its derivatives.
Kinga Linowiecka, Jolanta Guz, Tomasz Dziaman, Olga Urbanowska–Domańska, Ewelina Zarakowska, Anna Szpila, Justyna Szpotan, Aleksandra Skalska-Bugała, Paweł Mijewski, Agnieszka Siomek-Górecka, Rafał Różalski, Daniel Gackowski, Ryszard Oliński, Marek Foksiński   +13 more
doaj   +1 more source

TGF-β Drives DNA Demethylation [PDF]

Molecular Cell, 2012
In this issue of Molecular Cell, Thillainadesan et al. (2012) provide evidence that Smad proteins promote locus-specific active DNA demethylation as part of the transforming growth factor β (TGF-β) transcriptional response.
openaire   +2 more sources

Active DNA demethylation by oxidation and repair [PDF]

Cell Research, 2011
DNA methylation and demethylation are increasingly recognized as important epigenetic factors in both plants and animals. DNA methylation, which is catalyzed by DNA methyltransferases (DNMTs), is a relatively stable and heritable modification that controls gene expression, cellular differentiation, genomic imprinting, paramutation, transposon movement,
Gong, Zhizhong, Zhu, Jian-Kang
openaire   +3 more sources

Reimagining Lignin Valorization: Synthetic Biology–Enabled Sustainable Aromatic Carbon Biomanufacturing

Advanced Science, EarlyView.
The diagram illustrates a sustainable model of lignin valorization and carbon cycling based on microbial cell factories. Using lignin as the feedstock, synthetic biology technologies, including depolymerization, cell factory construction, pathway gene module integration, and metabolic network regulation, are applied to convert lignin into bulk ...
Na Li, Jun‐Jie Zhangyang, Bing‐Zhi Li, Zhi‐Hua Liu, Ying‐Jin Yuan   +4 more
wiley   +1 more source

DNA methylation and demethylation in adipocyte biology: roles of DNMT and TET proteins in metabolic disorders

Frontiers in Endocrinology
Adipocytes play a crucial role in regulating energy metabolism throughout the body. Dysfunctional adipocyte biology is a primary factor in the development of metabolic disorders associated with obesity and type 2 diabetes. Over the past decades, the role
Lijiao Wu, Xiangjin Wang, Luling Wang, Shuyan Li, Qiu Chen   +4 more
doaj   +1 more source