Results 71 to 80 of about 60,468 (238)

The level of active DNA demethylation compounds in leukocytes and urine samples as potential epigenetic biomarkers in breast cancer patients

Scientific Reports
The active DNA demethylation process, which involves TET proteins, can affect DNA methylation pattern. TET dependent demethylation results in DNA hypomethylation by oxidation 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) and its derivatives.
Kinga Linowiecka, Jolanta Guz, Tomasz Dziaman, Olga Urbanowska–Domańska, Ewelina Zarakowska, Anna Szpila, Justyna Szpotan, Aleksandra Skalska-Bugała, Paweł Mijewski, Agnieszka Siomek-Górecka, Rafał Różalski, Daniel Gackowski, Ryszard Oliński, Marek Foksiński   +13 more
doaj   +1 more source

Thinned young apple polyphenol prevents diabetic cardiomyopathy through promoting TET2-mediated active DNA demethylation in STZ-induced diabetic mice heart

Food Science and Human Wellness
Diabetic cardiomyopathy (DCM) refers diabetic patients develop cardiomyopathy characterized by cardiac systolic and diastolic dysfunction. Currently, no research has explored the role of ten-eleven translocation (TET)-mediated active DNA demethylation in
Run Liu, Zhongshi Qi, Liying Zhou, Jiacheng Fang, Shengjie Pei, Yanlei Yuan, Chunyan Tian, Yiding Zhang, Lei Chen, Duo Li   +9 more
doaj   +1 more source

TGF-β Drives DNA Demethylation [PDF]

Molecular Cell, 2012
In this issue of Molecular Cell, Thillainadesan et al. (2012) provide evidence that Smad proteins promote locus-specific active DNA demethylation as part of the transforming growth factor β (TGF-β) transcriptional response.
openaire   +2 more sources

Histone Demethylation and Timely DNA Replication [PDF]

Molecular Cell, 2010
It is well-established that silent regions of the genome replicate late during S phase. In this issue of Molecular Cell, Black et al. (2010) uncover a conserved role for the JMJD2 family of histone demethylases in promoting replication within silent chromatin regions that contain histone H3 lysine 9 methylation and HP1.
Gerace, Erica L., Moazed, Danesh
openaire   +2 more sources

Hemimethylation footprints of DNA demethylation in cancer [PDF]

Epigenetics, 2009
Hypomethylation of DNA repeats, including satellite 2 DNA (Sat2), is one of the most frequent epigenetic changes in cancer. We examined ovarian epithelial tumors and diverse control tissues for methylation on only one strand (hemimethylation), both strands (symmetrical methylation), or neither strand at Sat2 CpG dyads using hairpin genomic sequencing ...
Chunbo, Shao, Michelle, Lacey, Louis, Dubeau, Melanie, Ehrlich   +3 more
openaire   +2 more sources

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source

DNA methylation and demethylation in adipocyte biology: roles of DNMT and TET proteins in metabolic disorders

Frontiers in Endocrinology
Adipocytes play a crucial role in regulating energy metabolism throughout the body. Dysfunctional adipocyte biology is a primary factor in the development of metabolic disorders associated with obesity and type 2 diabetes. Over the past decades, the role
Lijiao Wu, Xiangjin Wang, Luling Wang, Shuyan Li, Qiu Chen   +4 more
doaj   +1 more source

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, EarlyView.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

DNA (cytosine‐5)‐methyltransferase 3A (Dnmt3a) mutations limit normal and autoreactive CD4+ T follicular helper responses and attenuate T cell‐driven joint inflammation

Arthritis &Rheumatology, Accepted Article.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased inflammatory markers. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source