Results 71 to 80 of about 2,593,032 (311)

Exploiting Chemical Diversity through C–H Activation and DNA-Encoding

, 2020
DNA-encoded library (DEL) technology has the potential to dramatically expedite hit identification in drug discovery owing to its ability to perform protein affinity selection with millions or billions of molecules in a single experiment.
Zhe Zhuang (6952247), Dominik K. Kölmel (8227006), Zhoulong Fan (8226966), Qian Shao (8227002), Jason Chen (5944203), Mark E. Flanagan (6565304), Shuai Zhao (8226986), Zi-Ning Cui (8226999), jin-quan yu (5485781), Tao Liu (8226993), David W. Piotrowski (6565314), Peng-Xiang Shen (8226996), Paul Richardson (6565316), Anokha S. Ratnayake (8227005)   +13 more
core   +1 more source

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases [PDF]

, 2012
The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood.
Julia Arand (155279), Meissner, A, Meilinger, D., Arand, Julia, Leonhardt, Heinrich, Jenuwein, Thomas, Wolf, Verena, Thomas Jenuwein (70681), Tommy Karius, David Spieler, Jenuwein, T., Xu, G, Tommy Karius (155285), Walter, Jörn, Wolf, V., Branco, MR, Leonhardt, H, Spieler, D, Branco, Miguel R., Meilinger, Daniela, Julia Arand, Jörn Walter, Walter, Joern, Jörn Walter (37094), Walter, J, Miguel R. Branco (42502), Verena Wolf, Karius, T, Meissner, Alexander, Arand, J, Alexander Meissner (11643), Meilinger, D, Daniela Meilinger, Heinrich Leonhardt (18589), Verena Wolf (155286), Daniela Meilinger (107843), Arand, J., Jenuwein, T, Miguel R Branco, Thomas Jenuwein, Guoliang Xu, Alexander Meissner, Walter, J., Meissner, A., Heinrich Leonhardt, Karius, Tommy, Guoliang Xu (67200), Spieler, David, Karius, T., Xu, Guoliang, David Spieler (155282), Branco, M., Xu, G., Wolf, V, Spieler, D., Leonhardt, H.   +55 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Novel Image Encryption Scheme Based on Two-Dimensional Chaotic Map Constructed from Ackley Function and DNA Operations

Entropy
In contemporary communication systems, digital images occupy an irreplaceable role; however, the privacy-related risks attendant to their prevalent application have grown increasingly salient.
Chao Jiang, Xiong Zhang, Xiaoqin Zhang
doaj   +1 more source

A Novel String Matrix Data Structure for DNA Encoding Algorithm [PDF]

, 2015
DNA Cryptography is a rapidly emerging field of DNA Computing research to provide invincible cryptographic technique for the modern cyber world of today and the futuristic DNA computers.
Balamurugan, Chithralekha, UbaidurRahman, Noorul Hussain, Mariappan, Rajapandian   +2 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Multiple pathways of plasmid DNA transfer in Helicobacter pylori [PDF]

, 2012
Many Helicobacter pylori (Hp) strains carry cryptic plasmids of different size and gene content, the function of which is not well understood. A subgroup of these plasmids (e.g.
Haas, Rainer, Rainer Haas, Lea Holsten (133951), Wolfgang Fischer (133965), Holsten, Lea, Stefanie Rohrer (133947), Rohrer, Stefanie, Rainer Haas (81562), Weiss, Evelyn, Lea Holsten, Mohammed Benghezal, Evelyn Weiss (133955), Mohammed Benghezal (133961), Stefanie Rohrer, Wolfgang Fischer, Benghezal, Mohammed, Evelyn Weiss, Fischer, Wolfgang   +17 more
core   +2 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Different immunogenicity but similar antitumor efficacy of two DNA vaccines coding for an antigen secreted in different membrane vesicle-associated forms

Journal of Extracellular Vesicles, 2014
The induction of an active immune response to control or eliminate tumours is still an unfulfilled challenge. We focused on plasmid DNA vaccines using an innovative approach whereby the antigen is expressed in association with extracellular vesicles (EVs)
Christine Sedlik, James Vigneron, Lea Torrieri-Dramard, Fabien Pitoiset, Jordan Denizeau, Caroline Chesneau, Philippe de la Rochere, Olivier Lantz, Clotilde Thery, Bertrand Bellier   +9 more
doaj   +1 more source

REPAIRtoire--a database of DNA repair pathways. [PDF]

, 2010
REPAIRtoire is the first comprehensive database resource for systems biology of DNA damage and repair. The database collects and organizes the following types of information: (i) DNA damage linked to environmental mutagenic and cytotoxic agents, (ii ...
Rother, Kristian, K. Poleszak, Papaj, Grzegorz, E. Osinska, Bujnicki, Janusz M, Lesiak, Justyna, G. Papaj, J. Lesiak, Milanowska, Kaja, J. Krwawicz, Kosinski, Jan, K. Rother, Krwawicz, Joanna, K. Milanowska, Poleszak, Katarzyna, Osinska, Ewelina, J. Kosinski, J. M. Bujnicki   +17 more
core   +1 more source