Results 51 to 60 of about 939,296 (267)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Diversity of Russula subg. Compactae (Russulales, Basidiomycota) in Ukraine

Ukrainian Botanical Journal
The article provides the first general overview of the species diversity of Russula subgenus Compactae in Ukraine in the last 50 years. We used both molecular methods (barcoding and metabarcoding) and results of classical field observations. In addition,
Fomenko M.I. , Prylutskyi O.V., Akulov O.Yu. , Zabolotnia A.S. , Rudenko Y.A. , Orinenko S.M. , Prydiuk M.P.   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Mycobacterium avium DNA extraction: Implications for NTM identification and amplicon sequencing

Southern African Journal of Infectious Diseases
This study evaluated six DNA (Deoxyribonucleic acid) extraction methods for Mycobacterium avium, focusing on cost, procedure time, yield, quality, DNA integrity, and suitability for amplicon-based sequencing.
Christoffel J. Opperman, Salim Ben Amor, Greshan Kisten, Brendon C. Mann, Janré Steyn, Sarishna Singh, Yonas Ghebrekristos, Robin Warren, Wynand Goosen   +8 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Lysis Buffers for Detecting Pork Content in Food Products

Indonesian Journal of Chemistry
The increasing number of counterfeit processed food products with non-halal ingredients, such as pork, has caused public concern about the halalness of Indonesian food products, especially in the Muslim community.
Ulfah Lailatul Khoiriah, Pramudja Baydillah, Raden Darmawan, Nasori Nasori, Fadlilatul Taufany, Setiyo Gunawan   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

DNA extraction: High yield is not synonymous with high diversity

Bioingeniøren, 2017
The quality, amount, and, in the case of polymicrobial samples, diversity of isolated DNA presupposes the precision of downstream application results. As part of a larger study on colorectal cancer, the aim of this work was to identify the DNA extraction
John Christopher Noone, Vahid Bemanian, Hege Smith Tunsjø   +2 more
doaj  

EVALUATION OF THE EFFICIENCY OF SAMPLING AND PRESERVING METHODS FOR NON-INVASIVE SAMPLES WHEN BROWN BEAR POPULATION-GENETIC STUDIES ARE CONDUCTING

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2019
The possibilities of using non-invasively sampled biological material to study the genetic diversity and status of the brown bear population in the European North of Russia are discussed.
Anastasiia Kuznetsova, Konstantin Tirronen, Danila Panchenko, Julia Schregel, Evgeny Khizhkin   +4 more
doaj   +1 more source