Results 101 to 110 of about 2,239,481 (376)

PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7

Nature Communications, 2016
Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is ...
Swapnil Rohidas Shinde, Subbareddy Maddika   +1 more
doaj   +1 more source

DNA Fingerprinting of Wolves

The UW National Parks Service Research Station Annual Reports, 1990
There are proposals to reintroduce (Canis lupus) to Yellowstone National Park through translocation of individuals from other populations. Ideally, these wolves should have a genotype similar to that possessed by the subspecies previously found in the Park. This genetic similarity would enhance the probability that genetically based adaptations to the
Patricia P. Rabenold, Mauricio De Gortari   +1 more
openaire   +3 more sources

Peptide mass fingerprinting using field-programmable gate arrays [PDF]

, 2009
The reconfigurable computing paradigm, which exploits the flexibility and versatility of field-programmable gate arrays (FPGAs), has emerged as a powerful solution for speeding up time-critical algorithms.
Beynon, R.J., Bogdan, I.A., Coca, D.
core   +1 more source

Advancing Clinical Medicine with Raman Spectroscopy: Current Trends and Future Perspectives

Advanced Photonics Research, EarlyView.
Raman spectroscopy and microscopy may become excellent tools in clinical medicine, including hematology, oncology, infectious diseases, neurology, gastroenterology, reproductive medicine, rheumatology, and cardiovascular research. However, many challenges such as signal interference, standardization issues, and limited clinical application need to be ...
Jiří Bufka, Lenka Vaňková, Josef Sýkora, Věra Křížková, Jan Schwarz, Petr Bouř   +5 more
wiley   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Cell Viability, Drug Screening, and Mechanism Study Under Mild Phototherapy Integrated Chemotherapy (PIC)

Advanced Science, EarlyView.
Mild phototherapy integrated chemotherapy (mild‐PIC) monitored by real‐time impedance spectroscopy enhances drug efficacy in liver cancer via the “More Light‐Aiding, Less Bonding (LALB)” mechanism, achieving higher targeting with lower toxicity. Abstract Phototherapy integrated chemotherapy (PIC) offers a promising cancer treatment strategy as single ...
Tongge Li, Shihui Wang, Qianhui Ling, Junyi Sun, Ning Yang, Zhanglei Fu, Zhaoyuan Zhang, Si Chen, Yanfei Wang, Ni Yu, Yafei Wang, Zhexuan Ding, Haodong Liu, Yanwei Jia, Yifang Wang, Xingcai Zhang   +15 more
wiley   +1 more source

Silicon µPCR chip for forensic STR profiling with hybeacon probe melting curves [PDF]

, 2019
The demand to perform forensic DNA profiling outside of centralized laboratories and on the crime scene is increasing. Several criminal investigations would benefit tremendously from having DNA based information available in the first hours rather than ...
Cornelis, Senne, Deforce, Dieter, Fauvart, Maarten, Gansemans, Yannick, Stakenborg, Tim, Tytgat, Olivier, Van Nieuwerburgh, Filip, Vander Plaetsen, Ann-Sophie, Wiederkehr, Rodrigo S   +8 more
core   +2 more sources

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Heterosis and DNA Fingerprinting in Chickens

Poultry Science, 1996
Enhancement of performance in traits of economic importance by use of heterosis (hybrid vigor) is routine in poultry breeding. There is, however, no reliable method to predict the level of heterosis that will occur from the mating of individuals from two populations. DNA fingerprints (DFP) were used as a measure of genetic distance between mating pairs
Jossi Hillel, Paul B. Siegel, E. A. Dunnington, A. Haberfeld   +3 more
openaire   +3 more sources

Development of a locus-specific, co-dominant SCAR marker for assisted-selection of the Sw-5 (Tospovirus resistance) gene cluster in a wide range of tomato accessions [PDF]

, 2010
The best levels of broad-spectrum Tospovirus resistance reported in tomatoes thus far are conferred by the Sw-5 locus. This locus contains at least five paralogues (denoted Sw-5a through Sw-5e), of which Sw-5b represents the actual resistance gene.
Boiteux, L.S., Dianese, E.C., Fonseca, M.E.N., Goldbach, R.W., Inoue-Nagata, A.K., Kormelink, R.J.M., Resende, R.O., de   +6 more
core   +2 more sources