Results 131 to 140 of about 20,880 (290)

Comprehensive genetic and epigenetic characterization of Lynch‐like syndrome patients

International Journal of Cancer, EarlyView.
What's New? Lynch‐like syndrome is associated with development of colorectal cancer (CRC) with microsatellite instability and loss of expression of certain mismatch repair (MMR) genes, similar to Lynch syndrome, but unlike Lynch syndrome, the genetic cause of Lynch‐like syndrome (LLS) remains unknown.
Francesca Pirini, Luciano Calzari, Gianluca Tedaldi, Michela Tebaldi, Valentina Zampiga, Ilaria Cangini, Rita Danesi, Mila Ravegnani, Valentina Arcangeli, Alessandro Passardi, Elisabetta Petracci, Sara Bravaccini, Giorgia Marisi, Alessandra Viel, Daniela Barana, Monica Pedroni, Luca Roncucci, Daniele Calistri, Davide Gentilini   +18 more
wiley   +1 more source

Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision [PDF]

, 2017
Thymine DNA glycosylase (TDG) and Nei-like 1 (NEIL1) have both been implicated in the base excision repair step of active DNA demethylation. The robust glycosylase activity of TDG on DNA substrates containing 5-formylcytosine (5fC) or 5-carboxylcytosine (
Bochtler, Matthias, Mierzejewska, Karolina, Slyvka, Anton   +2 more
core   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles

Nature Communications
Base excision repair (BER) is initialized by DNA glycosylases, which recognize and flip damaged bases out of the DNA duplex into the enzymes active site, followed by cleavage of the glycosidic bond.
Mengtian Ren, Fabian Gut, Yilan Fan, Jingke Ma, Xiajing Shan, Aysenur Yikilmazsoy, Mariia Likhodeeva, Karl-Peter Hopfner, Chuanzheng Zhou   +8 more
doaj   +1 more source

Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach

Data in Brief, 2022
This work presents new data on human endonuclease VIII-like 2 protein (hNEIL2), a part of DNA glycosylases of the helix–two-turn–helix structural superfamily. While X-ray structure of oNEIL2 (opossum Monodelphis) was resolved partially [1], the structure
Polina V. Zhdanova, Alexander A. Ishchenko, Alexander A. Chernonosov, Dmitry O. Zharkov, Vladimir V. Koval   +4 more
doaj  

Genome-Wide Identification of DNA Methylases and Demethylases in Kiwifruit (Actinidia chinensis)

Frontiers in Plant Science, 2020
DNA methylation plays an important role in a wide range of developmental and physiological processes in plants. It is primarily catalyzed and regulated by cytosine-5 DNA methyltransferases (C5-MTases) and a group of DNA glycosylases that act as ...
Yaoxin Zhang, Xiaoqing He, Haochen Zhao, Wencai Xu, Heng Deng, Huan Wang, Shuyue Wang, Dan Su, Zhenlei Zheng, Bin Yang, Don Grierson, Jun Wu, Mingchun Liu   +12 more
doaj   +1 more source

Unzipping of knotted DNA via nanopore translocation [PDF]

QRB Discovery 6 (2025) e4
DNA unzipping by nanopore translocation has implications in diverse contexts, from polymer physics to single-molecule manipulation to DNA-enzyme interactions in biological systems. Here we use molecular dynamics simulations and a coarse-grained model of DNA to address the nanopore unzipping of DNA filaments that are knotted. This previously unaddressed
arxiv   +1 more source

7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases [PDF]

, 2017
Hydroxyl radicals predominantly react with the C8 of purines forming 7,8-dihydro-8-oxoguanine (8oxoG) and 7,8-dihydro-8-oxoadenine (8oxoA) adducts, which are highly mutagenic in mammalian cells.
Couvé, Sophie, Ishchenko, Alexander A., Kunz, Christophe, Saparbaev, Murat, Schär, Primo, Talhaoui, Ibtissam   +5 more
core  

dUTPase based switch controls transfer of virulence genes in order to preserve integrity of the transferred mobile genetic elements [PDF]

, 2013
dUTPases ubiquitously regulate cellular dUTP levels to preserve genome integrity. Recently, several other cellular processes were reported to be controlled by dUTPases including the horizontal transfer of Staphylococcus aureus pathogenicity islands ...
Bendes, A., Besztercei, B., Leveles, I., Liliom, K., Nyíri, K., Németh-Pongrácz, V., Papp-Kádár, V., Pálinkás, H., Róna, G., Szabó, J. E., Tóth, J., Vértessy G., Beáta, Zagyva, I.   +12 more
core   +1 more source

Whole‐exome sequencing in families from Lifou Island (New Caledonia) reveals candidate variants involved in gout pathogenesis

Rheumatology &Autoimmunity, EarlyView.
Strategy to identify variants involved in gout pathogenesis in New Caledonia. Abstract Background Gout, which manifests as severe inflammation caused by excessive serum urate levels and monosodium urate deposits in the joints, is associated with multiple genomic loci in Europeans.
Philippe Georgel, Yves‐Marie Ducrot, Anne Molitor, Nicodème Paul, Lydie Naegely, Antoine Hanauer, Thomas Bardin, Gaston Rijo de Leon, Etienne Patin, Luis Quintana‐Murci, Mariko Matsui, Marc Jouan, Seiamak Bahram, Raphael Carapito   +13 more
wiley   +1 more source