Results 141 to 150 of about 20,880 (290)

DNA demethylation pathways: Additional players and regulators. [PDF]

, 2017
DNA demethylation can occur passively by "dilution" of methylation marks by DNA replication, or actively and independently of DNA replication. Direct conversion of 5-methylcytosine (5mC) to cytosine (C), as originally proposed, does not occur.
Abdouni, An, Arakawa, Barreto, Bellon, Bhutani, Bhutani, Blaschke, Boorstein, Bourc'his, Bransteitter, Brown, Buganim, Chakraborty, Chen, Chen, Chen, Chowdhury, Chung, Cortazar, Cortellino, Costa, Dai, Dai, Dang, Dawlaty, Dawlaty, Dawlaty, Delhommeau, Doege, Dominguez, Engel, Fortini, Foshay, Fousteri, Franchini, Fritz, Fritz, Gao, Ge, Gehring, Gjini, Grin, Gu, Guo, Guo, Habib, Hajkova, Hashimoto, Hashimoto, Hashimoto, Hashimoto, Hata, Hata, He, Henson, Hildrestrand, Hogenbirk, Hollander, Hon, Hu, Hu, Iiams, Inoue, Iqbal, Ito, Iyer, Jin, Jin, Jiricny, Jones, Kagiwada, Kaneda, Kellinger, Ko, Kosmider, Kou, Kriaucionis, Krokan, Kumar, Langemeijer, Larijani, Laukka, Lenz, Li, Li, Li, Li, Liu, Liutkeviciute, Lorsbach, Lu, Ma, Maiti, Maiti, Marusawa, Mayer, Moran-Crusio, Muller, Muramatsu, Muramatsu, Nabel, Nakanishi, Nemec, Niehrs, Nilsen, Ohno, Okano, Ooi, Pais, Pastor, Perez, Petersen-Mahrt, Pfaffeneder, Pollard, Popp, Rai, Raiber, Ramiro, Rangam, Revy, Rommel, Rusmintratip, Sabag, Sajadian, Santos, Schiesser, Schiesser, Schmitz, Schomacher, Sciacovelli, Sejersted, Shen, Shen, Shibutani, Shimamoto, Shimoda, Silverman, Spruijt, Stier, Szulik, Tahiliani, Tamura, Tan, Vartanian, Verdine, Wagner, Wang, Weber, Wijesinghe, Wojciechowski, Wu, Xiao, Xu, Xu, Xu, Xue, Yamazaki, Yin, Young, Zanotti, Zhao, Zhu   +162 more
core   +1 more source

Engineering of Peptide‐Inserted Base Editors with Enhanced Accuracy and Security

Small, Volume 21, Issue 14, April 9, 2025.
This work developed a novel peptide insertion strategy to enhance the performance of base editors. Through changing the composition and position of the inserted peptide, peptide‐inserted base editors are engineered to exhibit robust on‐target editing activity and improved precision.
Qi Chen, Yangning Sun, Jia Yao, Yingfan Lu, Ruikang Qiu, Fuling Zhou, Zixin Deng, Yuhui Sun   +7 more
wiley   +1 more source

Surveying the repair of ancient DNA from bones via high-throughput sequencing

BioTechniques, 2015
DNA damage in the form of abasic sites, chemically altered nucleotides, and strand fragmentation is the foremost limitation in obtaining genetic information from many ancient samples. Upon cell death, DNA continues to endure various chemical attacks such
Nathalie Mouttham, Jennifer Klunk, Melanie Kuch, Ron Fourney, Hendrik Poinar   +4 more
doaj   +1 more source

A Post‐Mortem Molecular Damage Profile in the Ancient Human Mitochondrial DNA

Molecular Ecology Resources, Volume 25, Issue 4, May 2025.
ABSTRACT Mitochondrial DNA (mtDNA) analysis is crucial for understanding human population structure and genetic diversity. However, post‐mortem DNA damage poses challenges, that make analysis difficult. DNA preservation is affected by environmental conditions which, among other factors, complicates the differentiation of endogenous variants from ...
Daniel R. Cuesta‐Aguirre, Cristina Amor‐Jimenez, Assumpció Malgosa, Cristina Santos   +3 more
wiley   +1 more source

ROS1 5-methylcytosine DNA glycosylase is a slow-turnover catalyst that initiates DNA demethylation in a distributive fashion [PDF]

, 2009
Arabidopsis ROS1 belongs to a family of plant 5-methycytosine DNA glycosylases that initiate DNA demethylation through base excision. ROS1 displays the remarkable capacity to excise 5-meC, and to a lesser extent T, while retaining the ability to ...
Agius, Bennett, Bennett, Bernstein, Bird, Blainey, Bradford, Carey, Castaing, Choi, Cokus, Denver, Dodson, Esteller, Francis, Gehring, Goll, Gong, Hardeland, Hedglin, Heinemann, Henderson, Jones, Jullien, Kinoshita, Klimasauskas, Krishnamurthy, Lister, Lloyd, Marcourt, Marenstein, Marenstein, Martienssen, María Isabel Ponferrada-Marín, Michaels, Morales-Ruiz, Morgan, Nash, Neddermann, O'Handley, Ortega-Galisteo, Penterman, Petronzelli, Porello, Rafael R. Ariza, Robertson, Roldan-Arjona, Sidorenko, Sidorenko, Sidorenko, Smith, Stivers, Suzuki, Tchou, Teresa Roldán-Arjona, Turner, Vidal, Waters, Waters, Williams, Zharkov, Zharkov, Zheng, Zhu   +63 more
core   +2 more sources

Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS‐STING Pathway and Reverses Macrophage‐Like VSMC Phenotypes in Progeroid DNA‐Repair‐Deficient Ercc1Δ/− Mice

Aging Cell, EarlyView.
Dietary restriction mitigates vascular aging in DNA‐repair‐deficient Ercc1Δ/− mice by reducing extracellular matrix remodeling, inflammation, oxidative stress, and switching of vascular smooth muscle cells to a macrophage‐like phenotype. Our findings suggest that the cGAS‐STING pathway plays a key role in vascular aging and that the benefits of dietary
S. J. M. Stefens, J. van der Linden, J. M. Heredia‐Genestar, R. M. C. Brandt, S. Barnhoorn, I. Nieuwenhuizen‐Bakker, N. van Vliet, J. H. M. Odijk, Y. Ridwan, D. Stuijts, M. Batenburg, J. H. J. Hoeijmakers, R. Kanaar, J. Essers, I. van der Pluijm   +14 more
wiley   +1 more source

The Fpg/Nei Family of DNA Glycosylases [PDF]

, 2012
During the initial stages of the base excision DNA repair (BER) pathway, DNA glycosylases are responsible for locating and removing the majority of endogenous oxidative base lesions.
Bandaru, Bandaru, Banerjee, Banerjee, Blainey, Blainey, Boiteux, Boiteux, Boiteux, Breimer, Brieba, Bruner, Cabrera, Cao, Chetsanga, Chetsanga, Coste, Coste, D'Ham, Dizdaroglu, Dong, Dou, Dou, Doublié, Dunn, Emsley, Fromme, Fromme, Fromme, Fromme, Gilboa, Golan, Guo, Hailer, Hamm, Hatahet, Hazra, Hazra, Hegde, Hildrestrand, Imamura, Imamura, Ishchenko, Ishchenko, Jaruga, Jiang, Jiang, Katafuchi, Kathe, Koval, Krishnamurthy, Krishnamurthy, Krokeide, Kropachev, Kuznetsov, Le Bihan, Liu, Luo, Maki, Melamede, Michaels, Michaels, Michaels, Michaels, Moriya, Morland, Nakano, O'Connor, O'Connor, Patro, Pereira de Jesus, Porecha, Pumo, Purmal, Qi, Qi, Rolseth, Serre, Shibutani, Sugahara, Takao, Takao, Takao, Tchou, Tchou, Tchou, Tchou, Theriot, Torisu, Verdine, Verdine, Wallace, Wallace, Wallace, Wiederhold, Wiederholt, Wiederholt, Wood, Yeo, Zaika, Zhao, Zharkov, Zharkov, Zharkov   +103 more
core   +1 more source

RBM39 Promotes Base Excision Repair to Facilitate the Progression of HCC by Stabilising OGG1 mRNA

Cell Proliferation, EarlyView.
Targeting RBM39 attenuates BER via destabilising OGG1 mRNA and potentiates KBrO3‐induced oxidative stress in HCC. Our study represents a valuable treatment strategy combining indisulam and an oxidative stress inducer in HCC. ABSTRACT Targeting base excision repair (BER) has been an attractive strategy in cancer therapeutics.
Hongda An, Anliang Xia, Siyuan Liu, Dongjun Luo, Longpo Geng, Binghua Li, Beicheng Sun, Zhu Xu   +7 more
wiley   +1 more source

DNA Linear Block Codes: Generation, Error-detection and Error-correction of DNA Codeword [PDF]

International Journal of Bioinformatics Intelligent Computing. 2022;1(2):103-126, 2019
In modern age, the increasing complexity of computation and communication technology is leading us towards the necessity of new paradigm. As a result, unconventional approach like DNA coding theory is gaining considerable attention. The storage capacity, information processing and transmission properties of DNA molecules stimulate the notion of DNA ...
arxiv  

DNA Glycosylases Define the Outcome of Endogenous Base Modifications. [PDF]

Int J Mol Sci, 2023
Lirussi L, Nilsen HL.
europepmc   +1 more source