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Prophylaxis of oxidative DNA damage by formamidopyrimidine‐DNA glycosylase
International Journal of Cancer, 2006AbstractLying at the gas‐exchange interface, lung epithelia may be at risk of oxidation‐induced mutagenesis. Further, inflammation processes possibly consequent on smoking liberate reactive oxygen species that multiply the carcinogenic effects of tobacco.
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The Use of DNA Glycosylases to Detect DNA Damage
1996DNA glycosylases, first reported by Lindahl (1974), catalyze the scission of the glycosidic bond releasing damaged or mispaired bases as the first step of the base excision repair pathway (Fig. 12.1) (Dianov and Lindahl, 1994). Removal of damaged bases by a DNA glycosylase is generally associated with a specific type of damage (e.g., uracil-DNA ...
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The influence of DNA glycosylases on spontaneous mutation
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1998Brian J. Glassner+2 more
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