Results 181 to 190 of about 20,880 (290)

Expanding the Spectrum of Canine Diffuse Large B‐Cell Lymphoma Genetic Aberrations Through Whole Genome Sequencing Analysis

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is one of the most prevalent haematological malignancies in both humans and dogs, characterised in both species by significant clinical heterogeneity and limited prognostic predictability. With the introduction of next‐generation sequencing (NGS) technologies in veterinary medicine over the past decade ...
Antonella Fanelli, Eugenio Mazzone, Diana Giannuzzi, Laura Marconato, Luca Aresu   +4 more
wiley   +1 more source

DNA Repair in Mammalian Cells: Mismatched repair: variations on a theme [PDF]

, 2018
.: Complementary base pairing underlies the genetic template function of the DNA double helix. Therefore, to assure faithful DNA transactions, cells must adhere to a strict application of the Watson-Crick base pairing principle.Yet, mispairing does arise
Kunz, C., Saito, Y., Schär, P.
core  

Selective RNA amplification: a novel method using dUMP-containing primers and uracil DNA glycosylase. [PDF]

, 1993
George W. Buchman, David M. Schuster, Ayoub Rashtchian   +2 more
openalex   +1 more source

Structural and Evolutionary Adaptations of Nei-Like DNA Glycosylases Proteins Involved in Base Excision Repair of Oxidative DNA Damage in Vertebrates. [PDF]

Oxid Med Cell Longev, 2022
Ahmad HI, Ahmad HI, Afzal G, Sadia S, Haider G, Ahmed S, Saeed S, Chen J.   +7 more
europepmc   +1 more source

A Proteomics Profiling Reveals the Neuroprotective Effects of Melatonin on Exogenous β‐amyloid‐42 Induced Mitochondrial Impairment, Intracellular β‐amyloid Accumulation and Tau Hyperphosphorylation in Human SH‐SY5Y Cells

Cell Biology International, Volume 49, Issue 6, Page 659-673, June 2025.
ABSTRACT Alzheimer's disease (AD) is prevalent in the elderly population and characterized by the intracellular accumulation of neurofibrillary tangles (NFTs), composed of tau proteins, and extracellular deposition of beta‐amyloid protein (Aβ). The present study aimed to investigate the neuroprotective effects of melatonin on Aβ42‐induced AD‐like ...
Jiraporn Panmanee, Matthew Phanchana, Phorutai Pearngam, Nopphon Petchyam, Kornkanok Promthep, Ponlawit Wisomka, Suchanoot Kutpruek, Supitcha Pannengpetch, Tanya Prasertporn, Sujira Mukda, Piyarat Govitrapong, Chutikorn Nopparat   +11 more
wiley   +1 more source

New Constructions of Reversible DNA Codes [PDF]

arXiv
DNA codes have many applications, such as in data storage, DNA computing, etc. Good DNA codes have large sizes and satisfy some certain constraints. In this paper, we present a new construction method for reversible DNA codes. We show that the DNA codes obtained using our construction method can satisfy some desired constraints and the lower bounds of ...
arxiv  

Effect of DNA Glycosylases OGG1 and Neil1 on Oxidized G-Rich Motif in the KRAS Promoter. [PDF]

Int J Mol Sci, 2021
Ferino A, Xodo LE.
europepmc   +1 more source

Clinical Implications of Mismatch Repair Deficiency in Pancreatic Ductal Adenocarcinoma

Cancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background Pancreatic cancer is a highly aggressive and lethal disease, characterized by a limited response to chemotherapy and overall poor prognosis. Pancreatic cancers with a distinct mismatch repair deficiency, although relatively rare, have been shown to be associated with markedly better outcomes in comparison.
Zachary Kaplan, Elizabeth Prezioso, Aditi Jain, Harish Lavu, Charles J. Yeo, Wilbur B. Bowne, Avinoam Nevler   +6 more
wiley   +1 more source

Targeted deaminase‐free T‐to‐G and C‐to‐K base editing in rice by fused human uracil DNA glycosylase variants

Plant Biotechnology Journal, Volume 23, Issue 4, Page 1257-1259, April 2025.
Yinghuang Wu, Xueying Wang, Haoyu Wang, Ying Han, Yaxuan Wang, Chunyu Zou, Jian‐Kang Zhu, Ming Li   +7 more
wiley   +1 more source

TET3 regulates hematopoietic stem cell homeostasis during embryonic and adult hematopoiesis

HemaSphere, Volume 9, Issue 5, May 2025.
ABSTRACT The ten‐eleven translocation family of enzymes (TET1/2/3) promotes DNA demethylation and is essential for hematopoiesis. While the roles of TET1 and TET2 are well‐studied in hematopoiesis, the requirement of TET3 in embryonic and adult hematopoiesis is less investigated.
Harmony C. Ketchum, Claudia Morganti, Chie Yanase, Blake Ebert, Keisuke Ito, Meelad M. Dawlaty   +5 more
wiley   +1 more source