Results 201 to 210 of about 2,038,987 (238)
Crystal Structure of Human Methyl-Binding Domain IV Glycosylase Bound to Abasic DNA
, 2012 Brittney A. Manvilla +4 more
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Mitochondrial DNA Instability and Neuroinflammation: Connecting the Dots Between Base Excision Repair and Neurodegenerative Disease. [PDF]
Genes (Basel)Pittman MN +3 more
europepmc +1 more source
What is in a name? Rethinking SMUG1 in genome maintenance. [PDF]
NAR CancerRudolfova N +5 more
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Telomeric DNA damage landscapes distinguish oxidative from inflammatory cellular stress. [PDF]
Nucleic Acids ResFleming AM, Burrows CJ.
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A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase
Nature, 1996Mispairs in DNA of guanine with uracil and thymine can arise as a result of deamination of cytosine and 5-methylcytosine, respectively. In humans such mispairs are removed by thymine-DNA glycosylase (TDG). By deleting the carboxy and amino termini of this enzyme we have identified a core region capable of processing G/U but not G/T mispairs.
P. Gallinari, J. Jiricny
semanticscholar +4 more sources
WIREs Computational Molecular Science, 2020
The information contained within DNA as a sequence of nucleobases is required for life of most organisms, yet can get altered when the nucleobases are damaged upon exposure to many internal (hormones) and external (ultraviolet sunlight, pollutants ...
Rajwinder Kaur, D. J. Nikkel, S. Wetmore
semanticscholar +1 more source
The information contained within DNA as a sequence of nucleobases is required for life of most organisms, yet can get altered when the nucleobases are damaged upon exposure to many internal (hormones) and external (ultraviolet sunlight, pollutants ...
Rajwinder Kaur, D. J. Nikkel, S. Wetmore
semanticscholar +1 more source
Molecular and Cellular Biochemistry, 1982
Various DNA glycosylases exist, which initiate the first step in base-excision repair. A summary of the kinetic and physical characteristics of three classes of DNA glycosylases are presented here. The first class discussed, include glycosylases which recognize alkylated DNA.
S J, Caradonna, Y C, Cheng
openaire +2 more sources
Various DNA glycosylases exist, which initiate the first step in base-excision repair. A summary of the kinetic and physical characteristics of three classes of DNA glycosylases are presented here. The first class discussed, include glycosylases which recognize alkylated DNA.
S J, Caradonna, Y C, Cheng
openaire +2 more sources
2001
More than 50% of colon cancer-associated mutations in the p53 tumor suppressor gene are C-->T transitions. The majority of them locate in CpG dinucleotides and are thought to have arisen through spontaneous hydrolytic deamination of 5-methylcytosine. This deamination process gives rise to G.T mispairs that need to be repaired to G.C in order to avoid C-
Hardeland, U. +5 more
openaire +3 more sources
More than 50% of colon cancer-associated mutations in the p53 tumor suppressor gene are C-->T transitions. The majority of them locate in CpG dinucleotides and are thought to have arisen through spontaneous hydrolytic deamination of 5-methylcytosine. This deamination process gives rise to G.T mispairs that need to be repaired to G.C in order to avoid C-
Hardeland, U. +5 more
openaire +3 more sources
The enigmatic thymine DNA glycosylase
DNA Repair, 2007When it was first isolated from extracts of HeLa cells in Josef Jiricny's laboratory, the thymine DNA glycosylase (TDG) attracted attention because of its ability to remove thymine, i.e. a normal DNA base, from G.T mispairs. This implicated a function of DNA base excision repair in the restoration of G.C base pairs following the deamination of a 5 ...
Cortázar, Daniel +4 more
openaire +3 more sources