Results 71 to 80 of about 2,038,987 (238)

A novel uracil-DNA glycosylase family related to the helix-hairpin-helix DNA glycosylase superfamily [PDF]

Nucleic Acids Research, 2003
Cytosine bases can be deaminated spontaneously to uracil, causing DNA damage. Uracil-DNA glycosylase (UDG), a ubiquitous uracil-excising enzyme found in bacteria and eukaryotes, is one of the enzymes that repair this kind of DNA damage. To date, no UDG-coding gene has been identified in Methanococcus jannaschii, although its entire genome was ...
Ji Hyung, Chung, Eun Kyoung, Im, Hyun-Young, Park, Jun Hye, Kwon, Seahyoung, Lee, Jaewon, Oh, Ki-Chul, Hwang, Jong Ho, Lee, Yangsoo, Jang   +8 more
openaire   +2 more sources

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Complex Roles of NEIL1 and OGG1: Insights Gained from Murine Knockouts and Human Polymorphic Variants

DNA, 2022
DNA glycosylases promote genomic stability by initiating base excision repair (BER) in both the nuclear and mitochondrial genomes. Several of these enzymes have overlapping substrate recognition, through which a degree of redundancy in lesion recognition
R. Stephen Lloyd
doaj   +1 more source

Detection of Damaged DNA Bases by DNA Glycosylase Enzymes [PDF]

Biochemistry, 2010
A fundamental and shared process in all forms of life is the use of DNA glycosylase enzymes to excise rare damaged bases from genomic DNA. Without such enzymes, the highly ordered primary sequences of genes would rapidly deteriorate. Recent structural and biophysical studies are beginning to reveal a fascinating multistep mechanism for damaged base ...
Joshua I, Friedman, James T, Stivers
openaire   +2 more sources

Predators of the two paropsine leaf beetles Paropsisterna cloelia and Paropsis charybdis in eucalypt plantations in Marlborough, New Zealand Prädatoren der zwei Blattkäfer Paropsisterna cloelia and Paropsis charybdis in Eukalyptusplantagen in Marlborough, Neuseeland

Agricultural and Forest Entomology, EarlyView.
Coccinellidae (Coleoptera), Miridae (Hemiptera), Hemerobiidae (Neuroptera), Pentatomidae (Hemiptera), Anystidae (Acari), Erythraeidae (Acari) and spiders (Araneidae, Oxyopidae and Salticidae) fed on the invasive paropsine leaf beetles in Marlborough, New Zealand.
Carolin Weser, Manpreet K. Dhami, Elena Moltchanova, Ana Podolyan, Toni M. Withers, Stephen M. Pawson   +5 more
wiley   +1 more source

An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis [corrected]. [PDF]

PLoS Genetics, 2015
Active DNA demethylation in plants occurs through base excision repair, beginning with removal of methylated cytosine by the ROS1/DME subfamily of 5-methylcytosine DNA glycosylases.
Yan Li, Dolores Córdoba-Cañero, Weiqiang Qian, Xiaohong Zhu, Kai Tang, Huiming Zhang, Rafael R Ariza, Teresa Roldán-Arjona, Jian-Kang Zhu   +8 more
doaj   +1 more source

Neil3 and NEIL1 DNA Glycosylases Remove Oxidative Damages from Quadruplex DNA and Exhibit Preferences for Lesions in the Telomeric Sequence Context*

Journal of Biological Chemistry, 2013
Background: BER of quadruplex structures and telomere DNA has not been well studied. Results: Neil3 and NEIL1 remove damages from quadruplex DNA and show telomeric sequence context effects. Conclusion: Neil3 and NEIL1 may be involved in repair of damages
Jia Zhou, Minmin Liu, A. Fleming, C. Burrows, S. Wallace   +4 more
semanticscholar   +1 more source

Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases [PDF]

DNA Repair, 2009
Formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) share an overall common three-dimensional structure and primary amino acid sequence in conserved structural motifs but have different substrate specificities, with bacterial Fpg proteins recognizing formamidopyrimidines, 8-oxoguanine (8-oxoG) and its oxidation products ...
Scott D, Kathe, Ramiro, Barrantes-Reynolds, Pawel, Jaruga, Michael R, Newton, Cynthia J, Burrows, Viswanath, Bandaru, Miral, Dizdaroglu, Jeffrey P, Bond, Susan S, Wallace   +8 more
openaire   +2 more sources

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

Biological Reviews, EarlyView.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira   +3 more
wiley   +1 more source

Ginsenoside Rd Attenuates DNA Damage by Increasing Expression of DNA Glycosylase Endonuclease VIII-like Proteins after Focal Cerebral Ischemia

Chinese Medical Journal, 2016
Background: Ginsenoside Rd (GSRd), one of the main active ingredients in traditional Chinese herbal Panax ginseng, has been found to have therapeutic effects on ischemic stroke.
Long-Xiu Yang, Xiao Zhang, Gang Zhao
doaj   +1 more source