Results 91 to 100 of about 7,004 (177)

CDK7 as a Potential Exploratory Biomarker for Distinguishing Acute Myocardial Infarction Subtypes via DDR Pathways: Evidence From a Bangladeshi Cohort

Clinical Cardiology, Volume 49, Issue 6, June 2026.
Differential expression of DNA damage response genes was evaluated in Bangladeshi AMI patients. CDK7 showed significantly higher expression in NSTEMI compared to STEMI, while ATM, OGG1, and NBN showed no subtype‐specific differences, highlighting potential transcriptional heterogeneity between AMI subtypes.
Rifat Hossain Ripon, Hasnat Zahin, Abdullah Al Noman, Abdullah Al Saba, Mohammad Sayem, A.H.M. Nurun Nabi, Tahirah Yasmin   +6 more
wiley   +1 more source

DNA damage measurements within tissue samples with Repair Assisted Damage Detection (RADD)

Current Research in Biotechnology, 2019
Exposures to genotoxic carcinogens and reactive species result in strand breaks and a spectrum of covalent modifications to DNA that can induce mutations and contribute to the initiation and progression of cancer. Measurements of DNA damage within tissue
Kevin J. Lee, Elise Mann, Luciana Madeira da Silva, Jennifer Scalici, Natalie R. Gassman   +4 more
doaj   +1 more source

Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review systematically explores exercise as a multi‐target intervention for RBD, highlighting its mechanisms of action and regulatory effects on key pathophysiological processes. ABSTRACT Backgrounds REM sleep behavior disorder (RBD) is a prodromal non‐motor symptom of Parkinson's disease (PD) and other α‐synucleinopathies, affecting approximately ...
Xinhui Qiu, Zihui Wang, Ruixue Xu, Yiying Hu, Weidong Le   +4 more
wiley   +1 more source

Surveying the repair of ancient DNA from bones via high-throughput sequencing

BioTechniques, 2015
DNA damage in the form of abasic sites, chemically altered nucleotides, and strand fragmentation is the foremost limitation in obtaining genetic information from many ancient samples. Upon cell death, DNA continues to endure various chemical attacks such
Nathalie Mouttham, Jennifer Klunk, Melanie Kuch, Ron Fourney, Hendrik Poinar   +4 more
doaj   +1 more source

Fusobacterium nucleatum in cancer: Interactions with microbiota, tumour colonisation and cancer progression

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
F. nucleatum colonises tumours through mucosal translocation, adjacent‐tissue migration and hematogenous dissemination. It promotes cancer progression via adhesion, inflammation, immune evasion, epigenetic remodelling and metastasis. Its effects on therapy response are tumour‐context dependent. Microbiome‐guided targeting may enable precision oncology.
Feng Zhao, Rui An, Shaobo Yu, Yilei Ma, Wangwang Liu, Caixia Sheng, Xinyou Xie, Jun Zhang   +7 more
wiley   +1 more source

DNA repair and disease: insights from the human DNA glycosylase NEIL family

Experimental and Molecular Medicine
The base excision repair pathway protects DNA from base damage via oxidation, deamination, alkylation and methylation. DNA glycosylases are key enzymes that recognize damaged bases in a lesion-specific manner and initiate the base excision repair process.
Yuna Hwang, Su-Jin Kang, Jieun Kang, Jeongwoo Choi, Seung-Jin Kim, Sunbok Jang   +5 more
doaj   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu, Chujuan Cui, Lingdong Kong, Qiang Xu, Haibo Cheng, Lisha Zhou, Yang Sun   +6 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Integrative Genomics Identifies Candidate Genes Underlying Trypanotolerance in Hybrid African Cattle

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT Integrative genomics combines data from different omics sources to link genotypes and phenotypes with the aim of unravelling biological networks and pathways that undergird complex traits, particularly with respect to disease. In this respect, integrative genomics, leveraging population and functional genomic data, can be employed to ...
Gillian P. McHugo, James A. Ward, Said Ismael Ng'ang'a, Laurent A. F. Frantz, John A. Browne, Michael Salter‐Townshend, Grace M. O'Gorman, Kieran G. Meade, Emmeline W. Hill, Thomas J. Hall, David E. MacHugh   +10 more
wiley   +1 more source