Results 101 to 110 of about 7,004 (177)
Research progress on the role of the NEIL family in cancer
Frontiers in Cell and Developmental BiologyCancer is the primary cause of death worldwide. Cancer occurrence and progression are closely associated with DNA damage repair. DNA glycosylase were the first enzymes to initiate base excision repair, and the Nei-like DNA glycosylase (NEIL) family has ...
Yinghan Chen +4 more
doaj +1 more source
Postepy biochemii, 2009 Uracil is one of four nitrogen bases, most frequently found in normal RNA. Uracyl can be found also in DNA as a result of enzymatic or non-enzymatic deamination of cytosine as well as misincorporation of dUMP instead of dTMP during DNA replication. Uracil from DNA can be removed by DNA repair enzymes with apirymidine site as an intermediate.
Dariusz, Pytel +4 more
openaire +1 more source
Journal of Biological Chemistry, 1982 A uracil-DNA-glycosylase from Micrococcus luteus has been purified more than 3,000-fold. The enzyme preparation appears homogeneous, according to the results of sodium dodecyl sulfate-polyacrylamide gel electrophoresis. It is devoid of nonspecific endonucleases, specific endonucleases for apurinic and apyrimidinic sites, 3-methyladenine or 7 ...
J P, Leblanc +3 more
openaire +2 more sources
Insect Molecular Biology, Volume 35, Issue 3, Page 232-245, June 2026.Comparison between developmental stages (larvae, pupae, worker) in Pogonomyrmex californicus revealed significant stage‐specific differences in Gene Body Methylated frequencies. Methylation sites were highly correlated between WGBS and ONT in P. californicus Genome‐wide methylation was low (~3%) and highly clustered within gene bodies (GBM), especially
Tania Chavarria‐Pizarro +4 more
wiley +1 more source
Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity. [PDF]
DNA Repair (Amst), 2023 Mu Y +6 more
europepmc +1 more source
Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1743-1750, June 2026.Adolescents with incidental colorectal adenomas require age‐conscious management balancing referral for genetic counseling with evidence‐based surveillance. This narrative review proposes a pragmatic clinical algorithm integrating adenoma characteristics, hereditary risk assessment, and guideline‐concordant follow‐up to support individualized ...
Brett J. Hoskins +5 more
wiley +1 more source
The Plant Journal, Volume 126, Issue 5, June 2026.Significance Statement This study provides a chloroplast‐ and mitochondrion‐specific random mutagenesis tool specialized for C‐to‐T substitutions, enabling organelle genome‐focused forward genetic analysis. By utilizing this tool, we can screen for organelle genome‐associated traits and isolate novel mutations that are not only of physiological ...
Nanami Kosaka +6 more
wiley +1 more source
The Impact of Human DNA Glycosylases on the Activity of DNA Polymerase β toward Various Base Excision Repair Intermediates. [PDF]
Int J Mol Sci, 2023 Bakman AS +5 more
europepmc +1 more source
Structural organization, evolution, and distribution of viral pyrimidine dimer-DNA glycosylases. [PDF]
Biophys Rev, 2022 Karmanova AN, Nikulin NA, Zimin AA.
europepmc +1 more source
Communications BiologyMitochondrial DNA release into the cytosol is a critical event in innate immune activation, often acting as a damage-associated molecular pattern (DAMP) that triggers inflammasome assembly.
Julia Elise Cabral +8 more
doaj +1 more source