Results 101 to 110 of about 7,033 (174)

Resisting Xylella fastidiosa: xylem anatomical changes in the susceptible olive cultivar Cellina di Nardò after long‐term infection

Plant Biology, Volume 28, Issue 5, Page 1628-1640, August 2026.
After long‐term infection, the susceptible O. europaea cultivar Cellina di Nardò modified its wood anatomical traits as an adaptive response to counteract Xylella fastidiosa, exhibiting spontaneous canopy restoration. Abstract The Xylella fastidiosa subsp.
E. Sabella, D. Greco, E. Nutricati, A. Frontini, L. De Bellis, M. Vergine, A. Luvisi   +6 more
wiley   +1 more source

MUTYH Cancer‐Associated Variants Within the Interdomain Connector Differentially Impact Glycosylase Activity and Cellular DNA Repair

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Functional analysis of cancer‐associated variants of the DNA repair enzyme MUTYH in the interdomain connector between the 8‐oxoguanine (OG) recognition and base excision domains reveals discordance between in vitro assays and OG:A repair in cells. This disconnect highlights the use of complementary biochemical and cellular assays to accurately classify
Cindy Khuu, Melody Malek, Savannah G. Conlon, Geoffrey P. Wadey, Carlos H. Trasviña‐Arenas, Sheila S. David   +5 more
wiley   +1 more source

Research progress on the role of the NEIL family in cancer

Frontiers in Cell and Developmental Biology
Cancer is the primary cause of death worldwide. Cancer occurrence and progression are closely associated with DNA damage repair. DNA glycosylase were the first enzymes to initiate base excision repair, and the Nei-like DNA glycosylase (NEIL) family has ...
Yinghan Chen, Muyun Ma, Aixue Zou, Xinjia Wang, Weiwei Dong   +4 more
doaj   +1 more source

Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity. [PDF]

DNA Repair (Amst), 2023
Mu Y, Zelazowska MA, Chen Z, Plummer JB, Dong Q, Krug LT, McBride KM.   +6 more
europepmc   +1 more source

[Uracil-DNA glycosylases].

Postepy biochemii, 2009
Uracil is one of four nitrogen bases, most frequently found in normal RNA. Uracyl can be found also in DNA as a result of enzymatic or non-enzymatic deamination of cytosine as well as misincorporation of dUMP instead of dTMP during DNA replication. Uracil from DNA can be removed by DNA repair enzymes with apirymidine site as an intermediate.
Dariusz, Pytel, Artur, Słupianek, Dominika, Ksiazek, Tomasz, Skórski, Janusz, Błasiak   +4 more
openaire   +1 more source

The Impact of Human DNA Glycosylases on the Activity of DNA Polymerase β toward Various Base Excision Repair Intermediates. [PDF]

Int J Mol Sci, 2023
Bakman AS, Boichenko SS, Kuznetsova AA, Ishchenko AA, Saparbaev M, Kuznetsov NA.   +5 more
europepmc   +1 more source

Structural organization, evolution, and distribution of viral pyrimidine dimer-DNA glycosylases. [PDF]

Biophys Rev, 2022
Karmanova AN, Nikulin NA, Zimin AA.
europepmc   +1 more source

Structural and Evolutionary Adaptations of Nei-Like DNA Glycosylases Proteins Involved in Base Excision Repair of Oxidative DNA Damage in Vertebrates. [PDF]

Oxid Med Cell Longev, 2022
Ahmad HI, Ahmad HI, Afzal G, Sadia S, Haider G, Ahmed S, Saeed S, Chen J.   +7 more
europepmc   +1 more source

Repair and DNA Polymerase Bypass of Clickable Pyrimidine Nucleotides

Biomolecules
Clickable nucleosides, most often 5-ethynyl-2′-deoxyuridine (EtU), are widely used in studies of DNA replication in living cells and in DNA functionalization for bionanotechology applications.
Anton V. Endutkin, Anna V. Yudkina, Timofey D. Zharkov, Alexander E. Barmatov, Daria V. Petrova, Daria V. Kim, Dmitry O. Zharkov   +6 more
doaj   +1 more source

NLRP10 engages oxidized DNA through a Schiff-base mechanism and dissociates from NLRP3 upon inflammasome activation

Communications Biology
Mitochondrial DNA release into the cytosol is a critical event in innate immune activation, often acting as a damage-associated molecular pattern (DAMP) that triggers inflammasome assembly.
Julia Elise Cabral, Angela Lackner, Wenjin Jiang, Sophia Lin, Haitian Zhou, Anna Wu, Courtney Demos, Minh Anh Pham, Reginald McNulty   +8 more
doaj   +1 more source