Results 141 to 150 of about 2,395,071 (348)
Autoregulation of the real-time kinetics of the human mitochondrial replicative helicase
Nature CommunicationsThe human mitochondrial helicase Twinkle is essential for mitochondrial DNA (mtDNA) replication and integrity. Using biochemical and single-molecule techniques, we investigated Twinkle’s real-time kinetics, including DNA loading, unwinding, and rewinding,
Ismael Plaza-G A +8 more
doaj +1 more source
, 2013 EC number 3.6.4.12 Systematic name ATP phosphohydrolase (DNA helix unwinding) Recommended name DNA helicase Synonyms 3’ to 5’ DNA helicase [35] 3’-5’ DNA helicase [55] 3’-5’ PfDH [55] 5’ to 3’ DNA helicase [19,42] AvDH1 [37] BACH1 helicase [34] BLM [28] BLM protein [28] BRCA1-associated C-terminal helicase [34] BcMCM [52] CeWRN ...
Schomburg, Dietmar, Schomburg, Ida
openaire +1 more source
ruvA Mutants that resolve Holliday junctions but do not reverse replication forks
, 2008 RuvAB and RuvABC complexes catalyze branch migration and resolution of Holliday junctions (HJs) respectively. In addition to their action in the last steps of homologous recombination, they process HJs made by replication fork reversal, a reaction which ...
Bradley Alison Sylvia +14 more
core +1 more source
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source
Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase
BMC Cell Biology, 2003 Background Bloom syndrome is one of the most cancer-predisposing disorders and is characterized by genomic instability and a high frequency of sister chromatid exchange. The disorder is caused by loss of function of a 3' to 5' RecQ DNA helicase, BLM. The
Paric Enesa +2 more
doaj +1 more source
RECQL: a DNA helicase in breast cancer
Oncotarget, 2015 We recently reported that mutations in the RECQL gene are associated with an increased risk of breast cancer [1]. We identified recurrent RECQL mutations in two founder populations in Poland and Quebec, Canada, and we found that these mutations increase the risk of breast cancer by 5-fold among unselected cases from Poland and by 16-fold among higher ...
Mohammad R, Akbari, Cezary, Cybulski
openaire +2 more sources
Phosphorylation events surrounding the DNA damage response in "Saccharomyces cerevisiae" [PDF]
, 2007 Protein phosphorylation mediated by checkpoint kinases is crucial for the cellular response to DNA damage. The sensor kinases Mec1 and Tel1 initiate the checkpoint signaling cascade by directly activating the checkpoint effector kinase Rad53.
Schleker, Thomas Andreas
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu +4 more
wiley +1 more source
Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus [PDF]
, 2014 RecG is a DNA translocase encoded by most species of bacteria. The Escherichia coli protein targets branched DNA substrates and drives the unwinding and rewinding of DNA strands.
Briggs, Geoffrey S. +13 more
core +1 more source
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source