Results 131 to 140 of about 1,562,024 (293)

Structures of nucleotide-bound Redondovirus Rep protein link conformation and function.

PLoS Pathogens
Circular Rep-encoding single-stranded DNA (CRESS-DNA) virus Rep proteins are multidomain enzymes that mediate viral DNA rolling-circle replication.
Saira Montermoso, Kushol Gupta, Ruth Anne Pumroy, Vera Moiseenkova-Bell, Frederic D Bushman, Gregory D Van Duyne   +5 more
doaj   +1 more source

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

Helicase-binding to DnaI exposes a cryptic DNA-binding site during helicase loading in Bacillus subtilis

, 2006
The Bacillus subtilis DnaI, DnaB and DnaD proteins load the replicative ring helicase DnaC onto DNA during priming of DNA replication. Here we show that DnaI consists of a C-terminal domain (Cd) with ATPase and DNA-binding activities and an N-terminal ...
Nicholas Dixon (20136564), Patrick M Schaeffer (20203089), Charikleia Ioannou (20123532), Panos Soultanas (22257)   +3 more
core   +1 more source

Suramin action in African trypanosomes involves a RuvB-like DNA helicase. [PDF]

Int J Parasitol Drugs Drug Resist, 2023
Albisetti A, Hälg S, Zoltner M, Mäser P, Wiedemar N.   +4 more
europepmc   +1 more source

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source

Functional interactions of Gp22 and Gp23 with Gp21 DNA helicase define the replication module of dairy-relevant Ceduovirus phage 94p4

Journal of Dairy Science
: Lactococcus lactis and Lactococcus cremoris strains play a vital role in dairy fermentations, yet their industrial use is threatened by bacteriophage infections that can lead to production failures.
Anna Santo, Magdalena Chmielewska-Jeznach, Tamara Aleksandrzak-Piekarczyk, Agnieszka K. Szczepankowska   +3 more
doaj   +1 more source

HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review). [PDF]

Oncol Rep, 2023
Tang N, Wen W, Liu Z, Xiong X, Wu Y.
europepmc   +1 more source

Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis

PROTEOMICS, EarlyView.
ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima, Wilson Dias Segura, Leonardo Brogliato de Moraes, Reinaldo Souza Oliveira, Pedro Henrique Corteletti Manfio, Alison Felipe Alencar Chaves, Wagner Luiz Batista   +6 more
wiley   +1 more source

Identification of the nuclear localization signal in the Saccharomyces cerevisiae Pif1 DNA helicase. [PDF]

PLoS Genet, 2023
Lee RS, Geronimo CL, Liu L, Twarowski JM, Malkova A, Zakian VA.   +5 more
europepmc   +1 more source

ATPase activity measurement of DNA replicative helicase from Bacillus stearothermophilus by malachite green method

, 2016
The DnaB helicase from Bacillus stearothermophilus (DnaBBst) was a model protein for studying the bacterial DNA replication. In this work, a non-radioactive method for measuring ATPase activity of DnaBBst helicase was described.
Wang, GG, Yang, M, Wang, GG (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Key Lab Environm & Appl Microbiol, Chengdu 610041, Peoples R China.   +2 more
core   +1 more source