Results 131 to 140 of about 2,395,071 (348)

New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy

Frontiers in Molecular Biosciences, 2018
Small molecules that deter the functions of DNA damage response machinery are postulated to be useful for enhancing the DNA damaging effects of chemotherapy or ionizing radiation treatments to combat cancer by impairing the proliferative capacity of ...
Arindam Datta, Robert M. Brosh
doaj   +1 more source

The DNA-binding domain of S. Pombe Mrc1 (Claspin) acts to enhance stalling at replication barriers [PDF]

, 2015
Funding: Marie Curie Cancer Care (J.Z. and J.Z.D.), Biotechnology and Biological Sciences Research Council (J.Z.D.) and Cancer Research UK (E.H.) supported this work.During S-phase replication forks can stall at specific genetic loci.
Dalgaard, J.Z., Emma Louise Godfrey, Zech, Jurgen, Emma Louise Godfrey (774106), Godfrey, E.L., Jacob Zeuthen Dalgaard, Hisao Masai (59105), Edgar Hartsuiker, Zech, J., Juergen Zech (774105), Jacob Zeuthen Dalgaard (774107), Masai, H., Hartsuiker, E., Juergen Zech, Edgar Hartsuiker (254659), Hisao Masai   +15 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

A Decade of Discovery—Eukaryotic Replisome Disassembly at Replication Termination

Biology
The eukaryotic replicative helicase (CMG complex) is assembled during DNA replication initiation in a highly regulated manner, which is described in depth by other manuscripts in this Issue.
Rebecca M. Jones, Alicja Reynolds-Winczura, Agnieszka Gambus   +2 more
doaj   +1 more source

Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase

eLife, 2017
Replicative helicases are ring-shaped hexamers that encircle DNA for duplex unwinding. The currently accepted view of hexameric helicase function is by steric exclusion, where the helicase encircles one DNA strand and excludes the other, acting as a ...
Lance Langston, Mike O’Donnell
doaj   +1 more source

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA [PDF]

, 2013
26.03.14 KB.
Cecile Evrin, Kawakami, H, Li, H, Riera, A, Alejandra Fernández-Cid, Jingchuan Sun, Riera, A., Stillman, B, Stillman, B., Stefan A Samel, Christian Speck, Hironori Kawakami, Speck, C., Samel, S. A., Fernandez-Cid, A., Samel, AS, Speck, C, Sun, J., Sun, J, Fernandez-Cid, A, Huilin Li, Evrin, C., Kawakami, H., Evrin, C, Li, H., Alberto Riera, Bruce Stillman   +26 more
core   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

A conserved MCM single-stranded DNA binding element is essential for replication initiation

eLife, 2014
The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA.
Clifford A Froelich, Sukhyun Kang, Leslie B Epling, Stephen P Bell, Eric J Enemark   +4 more
doaj   +1 more source

ATPase activity measurement of DNA replicative helicase from Bacillus stearothermophilus by malachite green method

, 2016
The DnaB helicase from Bacillus stearothermophilus (DnaBBst) was a model protein for studying the bacterial DNA replication. In this work, a non-radioactive method for measuring ATPase activity of DnaBBst helicase was described.
Wang, GG, Yang, M, Wang, GG (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Key Lab Environm & Appl Microbiol, Chengdu 610041, Peoples R China.   +2 more
core   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source