Results 111 to 120 of about 1,562,024 (293)

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

A Decade of Discovery—Eukaryotic Replisome Disassembly at Replication Termination

Biology
The eukaryotic replicative helicase (CMG complex) is assembled during DNA replication initiation in a highly regulated manner, which is described in depth by other manuscripts in this Issue.
Rebecca M. Jones, Alicja Reynolds-Winczura, Agnieszka Gambus   +2 more
doaj   +1 more source

Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells. [PDF]

, 2007
BACKGROUND: The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC components, we were interested in determining whether the entire cellular content was
Reina Hashimoto, Heck, Margarete M.S., Hashimoto, Reina, Sherkow, Jake, Sharron Vass, Heck, MM, Vass, Sharron, Hashimoto, R, Hashimoto Reina, Yamaguchi Masamitsu, Crevel, Gilles, Cotterill, S, Yamaguchi, M, Heck, Margarete M. S., Vass Sharron, Heck Margarete M.S., Sherkow Jake, Sherkow, Jacob S., Yamaguchi, Masamitsu, Sherkow, J, Cotterill Sue, Crevel Gilles, Margarete M S Heck, Crevel, G, Cotterill, Sue, Vass, S, Gilles Crevel, Margarete M.S. Heck, Jake Sherkow, Sue Cotterill, Masamitsu Yamaguchi   +30 more
core   +2 more sources

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Autoregulation of the real-time kinetics of the human mitochondrial replicative helicase

Nature Communications
The human mitochondrial helicase Twinkle is essential for mitochondrial DNA (mtDNA) replication and integrity. Using biochemical and single-molecule techniques, we investigated Twinkle’s real-time kinetics, including DNA loading, unwinding, and rewinding,
Ismael Plaza-G A, María Ortiz-Rodríguez, Seth P. Buchanan, Samuel Miguez-Amil, Kateryna M. Lemishko, Fernando Moreno-Herrero, Rafael Fernandez-Leiro, Grzegorz L. Ciesielski, Borja Ibarra   +8 more
doaj   +1 more source

A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin

Chemistry – A European Journal, EarlyView.
The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You, Monica Ching Suen, Haitao Miao, Yanyan Geng, Rahman Ud Din, Mu Yuan, Qiang Xue, Xiaoting Li, Naining Xu, Zhihong Guo, Hon‐Ming Lam, Kwok‐Wai Lo, Changdong Liu, Guang Zhu   +13 more
wiley   +1 more source

New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy

Frontiers in Molecular Biosciences, 2018
Small molecules that deter the functions of DNA damage response machinery are postulated to be useful for enhancing the DNA damaging effects of chemotherapy or ionizing radiation treatments to combat cancer by impairing the proliferative capacity of ...
Arindam Datta, Robert M. Brosh
doaj   +1 more source

RECQL: a DNA helicase in breast cancer

Oncotarget, 2015
We recently reported that mutations in the RECQL gene are associated with an increased risk of breast cancer [1]. We identified recurrent RECQL mutations in two founder populations in Poland and Quebec, Canada, and we found that these mutations increase the risk of breast cancer by 5-fold among unselected cases from Poland and by 16-fold among higher ...
Mohammad R, Akbari, Cezary, Cybulski
openaire   +2 more sources

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis [PDF]

, 2013
Completion of DNA replication needs to be ensured even when challenged with fork progression problems or DNA damage. PCNA and its modifications constitute a molecular switch to control distinct repair pathways. In yeast, SUMOylated PCNA (S-PCNA) recruits
Krejci, Lumir, Sebesta, Marek, Plault, Nicolas, Robert, Thomas, Burkovics, Péter, Marini, Victoria, Szukacsov, Valéria, Haracska, Lajos, Sisakova, Alexandra, Gangloff, Serge, Kolesar, Peter, Pintér, Lajos   +11 more
core   +2 more sources

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source