Results 91 to 100 of about 2,395,071 (348)

The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis

Nucleic Acids Research, 2011
Mitochondrial DNA replication is performed by a simple machinery, containing the TWINKLE DNA helicase, a single-stranded DNA-binding protein, and the mitochondrial DNA polymerase γ.
Elisabeth Jemt, G. Farge, S. Bäckström, T. Holmlund, C. Gustafsson, M. Falkenberg   +5 more
semanticscholar   +1 more source

Human RECQL5{beta} stimulates flap endonuclease 1 [PDF]

, 2010
Human RECQL5 is a member of the RecQ helicase family which is implicated in genome maintenance. Five human members of the family have been identified; three of them, BLM, WRN and RECQL4 are associated with elevated cancer risk. RECQL1 and RECQL5 have not
Dawut, Lale, Wang, Z, Hedayati, Mohammad, Hedayati, M, Croteau, Deborah L, Speina, Elzbieta, Speina, E, Janscak, Pavel, Bohr, Vilhelm A, May, Alfred, Croteau, D L, Schwendener, Sybille, Janscak, Pavel; https://orcid.org/, May, A, Dawut, L, Schwendener, S, Wang, Zhengming, Bohr, V A   +17 more
core   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Yeast Rad5 Protein Required for Postreplication Repair Has a DNA Helicase Activity Specific for Replication Fork Regression

Molecules and Cells, 2007
Summary Lesions in the template DNA strand block the progression of the replication fork. In the yeast Saccharomyces cerevisiae, replication through DNA lesions is mediated by different Rad6-Rad18-dependent means, which include translesion synthesis and ...
András Blastyák, Lajos Pintér, I. Unk, L. Prakash, S. Prakash, L. Haracska   +5 more
semanticscholar   +1 more source

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA.

Genes & Development, 2002
In wild-type Saccharomyces cerevisiae, replication forks slowed during their passage through telomeric C(1-3)A/TG(1-3) tracts. This slowing was greatly exacerbated in the absence of RRM3, shown here to encode a 5' to 3' DNA helicase. Rrm3p-dependent fork
A. Ivessa, Jin-Qiu Zhou, Vincent P. Schulz, E. Monson, V. Zakian   +4 more
semanticscholar   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD.

PLoS Biology, 2008
DNA damage recognition by the nucleotide excision repair pathway requires an initial step identifying helical distortions in the DNA and a proofreading step verifying the presence of a lesion.
Stefanie C Wolski, Jochen Kuper, Petra Hänzelmann, James J Truglio, Deborah L Croteau, Bennett Van Houten, Caroline Kisker   +6 more
doaj   +1 more source

The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus [PDF]

, 2011
The human Suv3 helicase has been shown to be a major player in mitochondrial RNA surveillance and decay. In the present study we identify two new interaction partners of hSUV3: the RPA (replication protein A0 and FEN1 (flap endonuclease).
Stępień, Piotr P., Bohr, Vilhelm A, Kulikowicz, Tomasz   +2 more
core  

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.

, 2010
RecQ helicases have attracted considerable interest in recent years due to their role in the suppression of genome instability and human diseases. These atypical helicases exert their function by resolving a number of highly specific DNA structures.
M. Berti, C. D. O. Cooper, Y. Zhang, Gileadi, Opher, Niesen, Frank H., O. King, Berti, M, Gileadi, O, A. C. W. Pike, Berti, Matteo, Vindigni, Alessandro, N. A. Burgess-Brown, Pike, AC, F. H. Niesen, King, O, Niesen, FH, A. Vindigni, Cooper, CD, R. Mendoza-Maldonado, King, Oliver, Burgess-Brown, Nicola, Mendoza-Maldonado, R, Vindigni, A, Zhang, Y, B. Lucic, Lucic, B, O. Gileadi, Burgess-Brown, NA, Pike, Ashley C.W., Lucic, Bojana, Zhang, Ying, Burgess-Brown, Nicola A., Mendoza-Maldonado, Ramiro, Cooper, Christopher D.O.   +33 more
core   +1 more source