Results 1 to 10 of about 31,064 (161)
History of DNA Helicases. [PDF]
Genes (Basel), 2020 Since the discovery of the DNA double helix, there has been a fascination in understanding the molecular mechanisms and cellular processes that account for: (i) the transmission of genetic information from one generation to the next and (ii) the remarkable stability of the genome.
Brosh RM, Matson SW.
europepmc +4 more sources
New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy [PDF]
Frontiers in Molecular Biosciences, 2018 Small molecules that deter the functions of DNA damage response machinery are postulated to be useful for enhancing the DNA damaging effects of chemotherapy or ionizing radiation treatments to combat cancer by impairing the proliferative capacity of ...
Arindam Datta, Robert M. Brosh
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Impact of age-associated cyclopurine lesions on DNA repair helicases. [PDF]
PLoS ONE, 2014 8,5' cyclopurine deoxynucleosides (cPu) are locally distorting DNA base lesions corrected by nucleotide excision repair (NER) and proposed to play a role in neurodegeneration prevalent in genetically defined Xeroderma pigmentosum (XP) patients.
Irfan Khan +7 more
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Targeting R-loops: diverse RNA helicases in R-loop resolution and their potential as targets for cancer therapy [PDF]
Frontiers in Cell and Developmental BiologyRNA helicases are enzymes that remodel RNA secondary structures and RNA-protein complexes using ATP-driven motor forces. They are known to participate in many essential cellular processes, including transcription, splicing, translation, RNA decay, and ...
Katherine Herrera +3 more
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Borrowing nuclear DNA helicases to protect mitochondrial DNA. [PDF]
Int J Mol Sci, 2015 In normal cells, mitochondria are the primary organelles that generate energy, which is critical for cellular metabolism. Mitochondrial dysfunction, caused by mitochondrial DNA (mtDNA) mutations or an abnormal mtDNA copy number, is linked to a range of human diseases, including Alzheimer’s disease, premature aging and cancer.
Ding L, Liu Y.
europepmc +4 more sources
DNA helicases involved in DNA repair and their roles in cancer [PDF]
Nature Reviews Cancer, 2013 Helicases have major roles in genome maintenance by unwinding structured nucleic acids. Their prominence is marked by various cancers and genetic disorders that are linked to helicase defects. Although considerable effort has been made to understand the functions of DNA helicases that are important for genomic stability and cellular homeostasis, the ...
Robert M Brosh
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ATP is dispensable for E. coli DNA replication and eukaryotic helicase activity [PDF]
Nature CommunicationsAdenosine triphosphate (ATP) hydrolysis is the main cellular source of energy used to drive biochemical reactions that are otherwise energetically unfavourable.
Richard R. Spinks +10 more
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G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets [PDF]
Current Medicinal Chemistry, 2019 Robert M Brosh, Jun Ding, M Brosh Robert
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Single-Molecule Insights Into the Dynamics of Replicative Helicases
Frontiers in Molecular Biosciences, 2021 Helicases are molecular motors that translocate along single-stranded DNA and unwind duplex DNA. They rely on the consumption of chemical energy from nucleotide hydrolysis to drive their translocation.
Richard R. Spinks +7 more
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Current Plant Biology, 2021 Helicases and translocases comprise one of the largest and highly conserved gene families in eukaryotic organisms, including plant. Members of this gene family are involved in a plethora of molecular processes related to DNA and RNA metabolism that are ...
Asif Ahmed Sami +3 more
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