Results 1 to 10 of about 47,217 (278)
History of DNA Helicases. [PDF]
Genes (Basel), 2020 Since the discovery of the DNA double helix, there has been a fascination in understanding the molecular mechanisms and cellular processes that account for: (i) the transmission of genetic information from one generation to the next and (ii) the remarkable stability of the genome.
Brosh RM, Matson SW.
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New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy [PDF]
Frontiers in Molecular Biosciences, 2018 Small molecules that deter the functions of DNA damage response machinery are postulated to be useful for enhancing the DNA damaging effects of chemotherapy or ionizing radiation treatments to combat cancer by impairing the proliferative capacity of ...
Arindam Datta, Robert M. Brosh
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Borrowing nuclear DNA helicases to protect mitochondrial DNA. [PDF]
Int J Mol Sci, 2015 In normal cells, mitochondria are the primary organelles that generate energy, which is critical for cellular metabolism. Mitochondrial dysfunction, caused by mitochondrial DNA (mtDNA) mutations or an abnormal mtDNA copy number, is linked to a range of human diseases, including Alzheimer’s disease, premature aging and cancer.
Ding L, Liu Y.
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Single-molecule sorting of DNA helicases. [PDF]
Methods, 2016 DNA helicases participate in virtually all aspects of cellular DNA metabolism by using ATP-fueled directional translocation along the DNA molecule to unwind DNA duplexes, dismantle nucleoprotein complexes, and remove non-canonical DNA structures. Post-translational modifications and helicase interacting partners are often viewed as determining factors ...
Bain FE, Wu CG, Spies M.
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Special Methods collection on DNA helicases. [PDF]
Methods, 2016 In this special Methods collection on DNA helicases, I have solicited articles from leading experts in the field with a priority to gather a defined series of papers on highly relevant topics that encompass biological, biochemical, and biophysical aspects of helicase function.
Brosh RM.
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Branching out with DNA helicases. [PDF]
Curr Opin Genet Dev, 2011 The proper resolution of branched DNA molecules, which arise during processes such as DNA replication, DNA repair, and transcription, is critical for the maintenance of the genome. Disruption of this process can lead to genome instability and cancer progression.
Yusufzai T, Kadonaga JT.
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Structural and functional insights into acidophilic helicases as DNA-unwinding motors [PDF]
Applied and Environmental MicrobiologyIn motor-assisted nanopore sensing, increasing the salt concentration improves the signal-to-noise ratio (SNR); however, helicases used as motor proteins generally fail to sustain efficient unwinding under high-salt conditions.
Ronghui Liu +8 more
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Novel mutations in the RECQL4 gene affect its helicase functions, interactions with the BLM helicase and chemotherapeutics-induced cell death [PDF]
Cell Death DiscoveryRecQ family of DNA helicases play pivotal roles in DNA replication, repair and responses to DNA damage or replication stress. Several human RecQ helicases are defective in diseases associated with chromosomal instability, premature aging and cancer.
Agnieszka Kaczmarczyk +11 more
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Integrating Structural, Biochemical, and Cellular Perspectives on the TFIIH Helicases XPB and XPD [PDF]
BiomoleculesXeroderma pigmentosum group B (XPB/ERCC3) and group D (XPD/ERCC2) helicases are integral components of the transcription factor IIH (TFIIH) complex, coordinating DNA unwinding during transcription initiation and nucleotide excision repair (NER).
Marco Bravo, Li Fan
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Continuous-time random walk model for the diffusive motion of helicases [PDF]
QRB DiscoveryDNA helicases are molecular motors that use the energy from nucleotide hydrolysis to move along DNA, promoting the unwinding or rewinding of the double helix.
Victor Rodríguez-Franco +4 more
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