Results 41 to 50 of about 1,489,376 (287)

Drosophila RecQ4 Is Directly Involved in Both DNA Replication and the Response to UV Damage in S2 Cells. [PDF]

, 2012
The RecQ4 protein shows homology to both the S.cerevisiae DNA replication protein Sld2 and the DNA repair related RecQ helicases. Experimental data also suggest replication and repair functions for RecQ4, but the precise details of its involvement remain
Miyata Seiji, Isabelle Crevel, Seiji Miyata, Vo, N, Gilles Crevel (33987), Vo Nicole, Cotterill, S, Isabelle Crevel (119003), Miyata, S, Sue Cotterill (33993), Hoa, L, Lily Hoa (119009), Crevel Isabelle, Hamid Sana, Nicole Vo (119001), Hoa Lily, Cotterill Sue, Sana Hamid, Crevel Gilles, Crevel, G, Crevel, I, Lily Hoa, Nicole Vo, Gilles Crevel, Sana Hamid (119006), Hamid, S, Sue Cotterill, Seiji Miyata (119012)   +27 more
core   +1 more source

The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans

Frontiers in Molecular Biosciences, 2021
G-quadruplexes (G4s) are stable non-canonical secondary structures formed by G-rich DNA or RNA sequences. They play various regulatory roles in many biological processes.
Yang Liu, Yang Liu, Yang Liu, Yang Liu, Xinting Zhu, Kejia Wang, Kejia Wang, Kejia Wang, Bo Zhang, Shuyi Qiu, Shuyi Qiu, Shuyi Qiu   +11 more
doaj   +1 more source

Switch-like control of helicase processivity by single-stranded DNA binding protein

eLife, 2021
Helicases utilize nucleotide triphosphate (NTP) hydrolysis to translocate along single-stranded nucleic acids (NA) and unwind the duplex. In the cell, helicases function in the context of other NA-associated proteins such as single-stranded DNA binding ...
Barbara Stekas, Steve Yeo, Alice Troitskaia, Masayoshi Honda, Sei Sho, Maria Spies, Yann R Chemla   +6 more
doaj   +1 more source

Taking a molecular motor for a spin : helicase mechanism studied by spin labelling and PELDOR [PDF]

, 2015
Welcome Trust programme grant [WT091825MA to M.F.W., J.H.N.]; Wellcome Trust multi-user equipment grant [099149/Z/12/Z]. Royal Society Wolfseon Merit Award (to M.F.W., J.H.N.).
James H. Naismith, Naismith, Jim, Olav Schiemann, Petrovic-Stojanovska, Biljana, Constantinescu Aruxandei, Diana, Schiemann, Olav, Diana Constantinescu-arux, Malcolm F. White, White, Malcolm F, Biljana Petrovic-stojanovska   +9 more
core   +1 more source

Amidst multiple binding orientations on fork DNA, Saccharolobus MCM helicase proceeds N-first for unwinding

eLife, 2019
DNA replication requires that the duplex genomic DNA strands be separated; a function that is implemented by ring-shaped hexameric helicases in all Domains.
Himasha M Perera, Michael A Trakselis
doaj   +1 more source

Putative SF2 helicases of the early-branching eukaryote Giardia lamblia are involved in antigenic variation and parasite differentiation into cysts

BMC Microbiology, 2012
Background Regulation of surface antigenic variation in Giardia lamblia is controlled post-transcriptionally by an RNA-interference (RNAi) pathway that includes a Dicer-like bidentate RNase III (gDicer).
Gargantini Pablo R, Serradell Marianela C, Torri Alessandro, Lujan Hugo D   +3 more
doaj   +1 more source

Characterisation of XPD from Sulfolobus acidocaldarius : an iron-sulphur cluster containing DNA repair helicase [PDF]

, 2007
DNA is constantly damaged by a variety of exogenous and endogenous sources. To maintain the integrity of the genome, different DNA repair mechanisms have evolved, which deal with different kinds of DNA damage.
Rudolf, Jana
core   +2 more sources

The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy

Frontiers in Molecular Biosciences, 2018
DNA helicases unwind or rearrange duplex DNA during replication, recombination and repair. Helicases of many pathogenic organisms such as viruses, bacteria, and protozoa have been studied as potential therapeutic targets to treat infectious diseases, and
Yeon-Soo Seo, Young-Hoon Kang
doaj   +1 more source

Remodeling the conformational dynamics of I-motif DNA by helicases in ATP-independent mode at acidic environment

iScience, 2022
Summary: I-motifs are noncanonical four-stranded DNA structures formed by C-rich sequences at acidic environment with critical biofunctions. The particular pH sensitivity has inspired the development of i-motifs as pH sensors and DNA motors in ...
Bo Gao, Ya-Ting Zheng, Ai-Min Su, Bo Sun, Xu-Guang Xi, Xi-Miao Hou   +5 more
doaj   +1 more source

Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks

eLife, 2017
Replicative helicases in all cell types are hexameric rings that unwind DNA by steric exclusion in which the helicase encircles the tracking strand only and excludes the other strand from the ring.
Lance D Langston, Ryan Mayle, Grant D Schauer, Olga Yurieva, Daniel Zhang, Nina Y Yao, Roxana E Georgescu, Mike E O'Donnell   +7 more
doaj   +1 more source