Results 21 to 30 of about 1,489,376 (287)

DNA Helicases as Safekeepers of Genome Stability in Plants. [PDF]

Genes (Basel), 2019
Genetic information of all organisms is coded in double-stranded DNA. DNA helicases are essential for unwinding this double strand when it comes to replication, repair or transcription of genetic information.
Dorn A, Puchta H.
europepmc   +2 more sources

RQC helical hairpin in Bloom's syndrome helicase regulates DNA unwinding by dynamically intercepting nascent nucleotides

iScience, 2022
Summary: The RecQ family of helicases are important for maintenance of genomic integrity. Although functions of constructive subdomains of this family of helicases have been extensively studied, the helical hairpin (HH) in the RecQ-C-terminal domain (RQC)
Jianbing Ma, Chunhua Xu, Jinghua Li, Xi-Miao Hou, Lin-Tai Da, Qi Jia, Xingyuan Huang, Jin Yu, Xuguang Xi, Ying Lu, Ming Li   +10 more
doaj   +1 more source

Visualizing helicases unwinding DNA at the single molecule level. [PDF]

, 2010
DNA helicases are motor proteins that catalyze the unwinding of double-stranded DNA into single-stranded DNA using the free energy from ATP hydrolysis. Single molecule approaches enable us to address detailed mechanistic questions about how such enzymes ...
Fili, Natali, Mashanov, Gregory I, Batters, C, Dillingham, MS, Yeeles, Joseph T P, Toseland, Christopher P, Mashanov, GI, Toseland, CP, Wallace, Mark I, Webb, Martin R, Molloy, JE, Batters, Christopher, Webb, MR, Wallace, Mark, Fili, N, Dillingham, Mark S, Yeeles, JT, Molloy, Justin E   +17 more
core   +1 more source

Human RECQL5{beta} stimulates flap endonuclease 1 [PDF]

, 2010
Human RECQL5 is a member of the RecQ helicase family which is implicated in genome maintenance. Five human members of the family have been identified; three of them, BLM, WRN and RECQL4 are associated with elevated cancer risk. RECQL1 and RECQL5 have not
Dawut, Lale, Wang, Z, Hedayati, Mohammad, Hedayati, M, Croteau, Deborah L, Speina, Elzbieta, Speina, E, Janscak, Pavel, Bohr, Vilhelm A, May, Alfred, Croteau, D L, Schwendener, Sybille, Janscak, Pavel; https://orcid.org/, May, A, Dawut, L, Schwendener, S, Wang, Zhengming, Bohr, V A   +17 more
core   +3 more sources

DNA Helicases

Cold Spring Harbor Symposia on Quantitative Biology, 1979
In summary, we postulate that DNA unwinding and ATP dephosphorylation are coupled in different ways, depending on whether the fibrous ATPase or one of the globular ATPases provides the catalytic agent. Unanswered is the question of whether there is stoichiometry of ATP utilization during the unwinding of a duplex, and unsolved is the role of the ...
Kuhn, B., Abdel-Monem, M., Hoffmann-Berling, H.   +2 more
openaire   +3 more sources

DNA Synthesis at a Fork in the Presence of DNA Helicases [PDF]

European Journal of Biochemistry, 1982
In a mixture of Escherichia coli DNA polymerase III holoenzyme, single‐strand‐binding protein, artificially forked λ bacteriophage DNA with primer annealed to the leading side of the fork, dNTPs and ATP, DNA synthesis is enhanced by helicaseII, less so by helicases I, III or rep protein of E. coli or T4 phage helicase. The effect of helicase II depends
Kuhn, B., Abdel‐Monem, M.
openaire   +3 more sources

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation. [PDF]

, 2010
RecQ helicases have attracted considerable interest in recent years due to their role in the suppression of genome instability and human diseases. These atypical helicases exert their function by resolving a number of highly specific DNA structures.
M. Berti, C. D. O. Cooper, Y. Zhang, Gileadi, Opher, Niesen, Frank H., O. King, Berti, M, Gileadi, O, A. C. W. Pike, Berti, Matteo, Vindigni, Alessandro, N. A. Burgess-Brown, Pike, AC, F. H. Niesen, King, O, Niesen, FH, A. Vindigni, Cooper, CD, R. Mendoza-Maldonado, King, Oliver, Burgess-Brown, Nicola, Mendoza-Maldonado, R, Vindigni, A, Zhang, Y, B. Lucic, Lucic, B, O. Gileadi, Burgess-Brown, NA, Pike, Ashley C.W., Lucic, Bojana, Zhang, Ying, Burgess-Brown, Nicola A., Mendoza-Maldonado, Ramiro, Cooper, Christopher D.O.   +33 more
core   +1 more source

Helicases and DNA dependent ATPases of Sulfolobus solfataricus [PDF]

, 2008
Electronic version does not contain associated previously published materialDNA is susceptible to various types of damage as a result of normal cellular metabolism or from environmental sources.
Richards, Jodi D.
core   +2 more sources

DNA Helicases [PDF]

EcoSal Plus, 2010
DNA and RNA helicases are organized into six superfamilies of enzymes on the basis of sequence alignments, biochemical data, and available crystal structures. DNA helicases, members of which are found in each of the superfamilies, are an essential group of motor proteins that unwind DNA duplexes into their component single strands in a ...
openaire   +2 more sources

The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway [PDF]

, 2010
Xeroderma pigmentosum factor D (XPD) is a 5'-3' superfamily 2 helicase and the founding member of a family of DNA helicases with iron-sulphur cluster domains.
Rouillon, Christophe, Schwarz-Linek, Ulrich, Rudolf, Jana, White, Malcolm F   +3 more
core   +1 more source