Results 11 to 20 of about 47,217 (278)
Single-Molecule Insights Into the Dynamics of Replicative Helicases
Frontiers in Molecular Biosciences, 2021 Helicases are molecular motors that translocate along single-stranded DNA and unwind duplex DNA. They rely on the consumption of chemical energy from nucleotide hydrolysis to drive their translocation.
Richard R. Spinks +7 more
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Current Plant Biology, 2021 Helicases and translocases comprise one of the largest and highly conserved gene families in eukaryotic organisms, including plant. Members of this gene family are involved in a plethora of molecular processes related to DNA and RNA metabolism that are ...
Asif Ahmed Sami +3 more
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Impact of age-associated cyclopurine lesions on DNA repair helicases. [PDF]
PLoS ONE, 2014 8,5' cyclopurine deoxynucleosides (cPu) are locally distorting DNA base lesions corrected by nucleotide excision repair (NER) and proposed to play a role in neurodegeneration prevalent in genetically defined Xeroderma pigmentosum (XP) patients.
Irfan Khan +7 more
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Helicase: A genetic tool for providing stress tolerance in plants
Plant Stress, 2023 Alteration of stress (abiotic and biotic) constitutes one of the major problems for normal plants health. In the present scenario, new molecular tools are broadly utilized to improve stress tolerance and high-yielding crop plants.
Monalisha Das Mohapatra +3 more
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RecQ Helicase Somatic Alterations in Cancer
Frontiers in Molecular Biosciences, 2022 Named the “caretakers” of the genome, RecQ helicases function in several pathways to maintain genomic stability and repair DNA. This highly conserved family of enzymes consist of five different proteins in humans: RECQL1, BLM, WRN, RECQL4, and RECQL5 ...
Megha K. Thakkar +6 more
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Eukaryotic DNA helicases [PDF]
FEBS Letters, 1990 DNA is very stable in its double‐stranded form. For many processes of DNA metabolism, such as replication, repair, recombination and transcription, the DNA has to be brought transiently into a single‐stranded form. DNA helicases are enzymes capable of melting the hydrogen bonds of base pairs by using the energy of nucleoside‐5'‐triphosphate hydrolysis.
Thömmes, Pia, Hübscher, Ulrich
openaire +2 more sources
BLM and RMI1 alleviate RPA inhibition of topoIIIα decatenase activity [PDF]
, 2012 RPA is a single-stranded DNA binding protein that physically associates with the BLM complex. RPA stimulates BLM helicase activity as well as the double Holliday junction dissolution activity of the BLM-topoisomerase IIIα complex.
A Bochkarev +39 more
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iScience, 2021 Summary: G-quadruplexes (G4s) are non-canonical DNA structures with critical roles in DNA metabolisms. To resolve those structures that can cause replication fork stalling and genomic instability, single-stranded DNA-binding proteins and helicases are ...
Yi-Ran Wang +6 more
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Human RecQ Helicases in DNA Double-Strand Break Repair
Frontiers in Cell and Developmental Biology, 2021 RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and animals. These helicases play important roles in multiple cellular functions, including DNA replication, transcription, DNA repair, and telomere maintenance.
Huiming Lu, Anthony J. Davis
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Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. [PDF]
PLoS ONE, 2007 DNA helicases are ubiquitous enzymes that unwind DNA in an ATP-dependent and directionally specific manner. Unwinding of double-stranded DNA is essential for the processes of DNA repair, recombination, transcription, and DNA replication.
Sudha Sharma, Robert M Brosh
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