Results 11 to 20 of about 1,489,376 (287)
Eukaryotic DNA helicases [PDF]
FEBS Letters, 1990 DNA is very stable in its double‐stranded form. For many processes of DNA metabolism, such as replication, repair, recombination and transcription, the DNA has to be brought transiently into a single‐stranded form. DNA helicases are enzymes capable of melting the hydrogen bonds of base pairs by using the energy of nucleoside‐5'‐triphosphate hydrolysis.
Thömmes P, Hübscher U
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The RecQ DNA Helicases in DNA Repair [PDF]
Annual Review of Genetics, 2010 The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop)
Bernstein, Kara +2 more
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Helicase: A genetic tool for providing stress tolerance in plants
Plant Stress, 2023 Alteration of stress (abiotic and biotic) constitutes one of the major problems for normal plants health. In the present scenario, new molecular tools are broadly utilized to improve stress tolerance and high-yielding crop plants.
Monalisha Das Mohapatra +3 more
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iScience, 2021 Summary: G-quadruplexes (G4s) are non-canonical DNA structures with critical roles in DNA metabolisms. To resolve those structures that can cause replication fork stalling and genomic instability, single-stranded DNA-binding proteins and helicases are ...
Yi-Ran Wang +6 more
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Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases. [PDF]
Genes (Basel), 2020 With roles in DNA repair, recombination, replication and transcription, members of the RecQ DNA helicase family maintain genome integrity from bacteria to mammals.
Gupta SV, Schmidt KH.
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RecQ Helicase Somatic Alterations in Cancer
Frontiers in Molecular Biosciences, 2022 Named the “caretakers” of the genome, RecQ helicases function in several pathways to maintain genomic stability and repair DNA. This highly conserved family of enzymes consist of five different proteins in humans: RECQL1, BLM, WRN, RECQL4, and RECQL5 ...
Megha K. Thakkar +6 more
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Human RecQ Helicases in DNA Double-Strand Break Repair
Frontiers in Cell and Developmental Biology, 2021 RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and animals. These helicases play important roles in multiple cellular functions, including DNA replication, transcription, DNA repair, and telomere maintenance.
Huiming Lu, Anthony J. Davis
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Getting it done at the ends: Pif1 family DNA helicases and telomeres. [PDF]
DNA Repair (Amst), 2016 It is widely appreciated that the ends of linear DNA molecules cannot be fully replicated by the conventional replication apparatus. Less well known is that semi-conservative replication of telomeric DNA also presents problems for DNA replication ...
Geronimo CL, Zakian VA.
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Unwinding of Nucleosomal DNA by a DNA Helicase [PDF]
Journal of Biological Chemistry, 1995 We have asked whether a DNA helicase can unwind DNA contained within both isolated native chromatin and reconstituted chromatin containing regularly spaced arrays of nucleosome cores on a linear tandem repeat sequence. We find that Escherichia coli recBCD enzyme is capable of unwinding these DNA substrates and displacing the nucleosomes, although both ...
A K, Eggleston +3 more
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Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. [PDF]
PLoS ONE, 2007 DNA helicases are ubiquitous enzymes that unwind DNA in an ATP-dependent and directionally specific manner. Unwinding of double-stranded DNA is essential for the processes of DNA repair, recombination, transcription, and DNA replication.
Sudha Sharma, Robert M Brosh
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