Results 171 to 180 of about 1,562,024 (293)

TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics

The FEBS Journal, EarlyView.
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga, Zsolt Ráduly, Beáta Boros‐Oláh, Éva Nagy, Zsolt Karányi, László Halász, Bálint László Bálint, György Vámosi, Emese Tóth, Péter Bai, Serena Santangelo, Patrizia Bossolasco, Antonia Ratti, Vincent Géli, Yves Pommier, Lóránt Székvölgyi   +15 more
wiley   +1 more source

HELZ is a RNA-DNA helicase that resolves R loops to facilitate homologous recombination repair. [PDF]

Nat Commun
Haji-Seyed-Javadi R, Koyen AE, Rath SK, Wu B, Madden MZ, Hou Y, Kapoor-Vazirani P, Roshika R, Aiello M, Luong NC, Tseng WC, Sesay F, Kim JS, Tan T, Kim S, Gao B, Song BS, Kenney AM, Connolly EC, Yang L, Xhemalce B, Li X, Switchenko JM, Yang X, Buchwald ZS, Deng X, Miller KM, Yao B, Lan L, Zhao W, Yu DS.   +30 more
europepmc   +1 more source

ATP-dependent DNA helicase (TaDHL), a Novel Reduced-Height (Rht) Gene in Wheat. [PDF]

Genes (Basel), 2022
Guo B, Jin X, Chen J, Xu H, Zhang M, Lu X, Wu R, Zhao Y, Guo Y, An Y, Li S.   +10 more
europepmc   +1 more source

Ploidy‐dependent modulation of DNA replication kinetics in Xenopus

The FEBS Journal, EarlyView.
Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash, Olivier Haccard, Zhen Li, Nicolas Pollet, Kathrin Marheineke   +4 more
wiley   +1 more source

BRIP1, a G-quadruplex DNA helicase, protects against AID-induced genomic instability by limiting R-loop accumulation. [PDF]

Mol Med
Mahboob A, Ahmad H, Fatma N, Begum NA, Husain A.   +4 more
europepmc   +1 more source

SSB Facilitates Fork-Substrate Discrimination by the PriA DNA Helicase. [PDF]

ACS Omega, 2021
Tan HY, Bianco PR.
europepmc   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Loss of mitochondrial DNA helicase in retinal macroglia drives neovascular retinopathy. [PDF]

EMBO Mol Med
Olander S, Karaman S, Suomi F, Aguilar K, Zhaivoron A, Nedergaard M, Smeds L, Tiihonen J, Quintana A, Hidalgo J, Alitalo K, Ala-Laurila P, Ince-Dunn G, Suomalainen A.   +13 more
europepmc   +1 more source

Selective role of the DNA helicase Mcm5 in BMP retrograde signaling during Drosophila neuronal differentiation. [PDF]

PLoS Genet, 2022
Rubio-Ferrera I, Baladrón-de-Juan P, Clarembaux-Badell L, Truchado-Garcia M, Jordán-Álvarez S, Thor S, Benito-Sipos J, Monedero Cobeta I.   +7 more
europepmc   +1 more source

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source