Results 221 to 230 of about 2,395,071 (348)

Author Correction: Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation. [PDF]

EMBO J
van Deursen F, Sengupta S, De Piccoli G, Sanchez-Diaz A, Labib K.   +4 more
europepmc   +1 more source

Role of the DDX11 DNA Helicase in Warsaw Breakage Syndrome Etiology. [PDF]

Int J Mol Sci, 2021
Santos D, Mahtab M, Boavida A, Pisani FM.   +3 more
europepmc   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

Specific Monitoring the DNA Helicase Function via Anchor-Embedded DNA Probe. [PDF]

Adv Sci (Weinh)
Ning K, Tang X, Li Z, Zhong L, Zhou Y, Wang J, Huang W, Zhang H, Ke J, Luan T, Chen SB, Zhai J.   +11 more
europepmc   +1 more source

Chl1, an ATP-Dependent DNA Helicase, Inhibits DNA:RNA Hybrids Formation at DSB Sites to Maintain Genome Stability in S. pombe. [PDF]

Int J Mol Sci, 2022
He D, Du Z, Xu H, Bao X.
europepmc   +1 more source

The role of protein kinases in DNA replication in Saccharomyces cerevisiae

, 2010
The initiation of DNA replication at the onset of S phase in eukaryotic cells is a critically important and tightly regulated process. Multiple origins of replication in the genome must be co-ordinately regulated such that duplication of the chromosomes ...
Sweet, S.
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Evidence of an unprecedented cytoplasmic function of DDX11, the Warsaw breakage syndrome DNA helicase, in regulating autophagy. [PDF]

Autophagy
Bonavita R, Prodomo A, Cortone G, Vitale F, Germoglio M, Fleming A, Balk JA, de Lange J, Renna M, Pisani FM.   +9 more
europepmc   +1 more source

The Genome Stability Maintenance DNA Helicase DDX11 and Its Role in Cancer. [PDF]

Genes (Basel), 2021
Mahtab M, Boavida A, Santos D, Pisani FM.   +3 more
europepmc   +1 more source

Structural and biochemical studies of MCM proteins

, 2010
The eukaryotic MCM2-7 replicative helicase is a hetero-complex composed by 6 homologues belonging to the AAA+ ATPase superfamily. These proteins form a ring-like structure which is essential for the initiation and the progression of the replication fork.
Medagli, Barbara
core