Results 241 to 250 of about 1,562,024 (293)

Srs2/PARI DNA helicase mediates abscission inhibition in response to chromatin bridges in yeast and human cells

Dam M, Brownlow N, Furst A, Spiegelhalter C, Mendoza M.   +4 more
europepmc   +1 more source

A DRACH Observed/Expected Metric Reveals the Evolutionary Landscape of Epitranscriptomic Regulation Across Bilateria

Annals of the New York Academy of Sciences, Volume 1564, Issue 1, October 2026.
Epitranscriptomic marks are highly variable across life stages and tissues, complicating comparisons between species. Using m6A consensus motifs, we developed a genomic indicator reflecting transcript methylability, the DRACH o/e score, that we used to investigate epitranscriptomic features and associated functions across nine bilaterian species.
Natacha Clairet, Jérémy Le Luyer, Hélène Auger, Maximilian Haeussler, Guillaume Rivière   +4 more
wiley   +1 more source

Targeted Modulation of Eukaryotic Release Factor 1 (OseRF1) by an RNA Aptamer Enhances Drought Adaptation in Rice

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5440-5459, October 2026.
ABSTRACT Drought stress severely restricts rice productivity, necessitating strategies to enhance stress resilience. Here, we identify translation termination as a tunable regulatory node for stress adaptation. Using 25 rounds of SELEX, we isolated RTAR, an RNA aptamer that binds the rice eukaryotic release factor 1 (OseRF1) with nanomolar affinity ...
Shuangfeng Dai, Mingming Chen, Haomin Chen, Yuantao Ye, Hong Huang, Renrong Zhang, Zhenyu Guo, Yongxiang Huang   +7 more
wiley   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Calcium phosphate biomineralization has traditionally been considered a protein‐regulated process. This review highlights the emerging role of nucleic acids, which interact with mineral phases through adsorption, coprecipitation, and templating, thereby influencing crystal nucleation and growth.
Fanny Duhalde, Jessem Landoulsi, Xavier Houard   +2 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Inhibition of DNA helicases with DNA-competitive inhibitors

Bioorganic & Medicinal Chemistry Letters, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sandy, Dubaele, Wolfang, Jahnke, Joseph, Schoepfer, Jean, Fuchs, Patrick, Chène   +4 more
openaire   +2 more sources

RECQ DNA Helicases and Osteosarcoma

2020
The RECQ family of DNA helicases is a conserved group of enzymes that plays an important role in maintaining genomic stability. Humans possess five RECQ helicase genes, and mutations in three of them - BLM, WRN, and RECQL4 - are associated with the genetic disorders Bloom syndrome, Werner syndrome, and Rothmund-Thomson syndrome (RTS), respectively ...
Linchao, Lu, Weidong, Jin, Lisa L, Wang
openaire   +2 more sources

DNA Helicases

2018
This chapter discusses the application of single-molecule approaches in the study of helicases. It describes the main helicase families and possible mechanisms of their action, and the problems of bulk experiments on helicases resulting from rehybridization of unwound strands in the wake of the enzyme; this problem is absent for RecBCD, a helicase ...
David Bensimon, Vincent Croquette, Jean-François Allemand, Xavier Michalet, Terence Strick   +4 more
openaire   +1 more source