Results 251 to 260 of about 1,562,024 (293)

DNA helicases: ‘inching forward’

Current Opinion in Structural Biology, 2000
Recently determined crystal structures of PcrA helicase complexed with a DNA substrate have revealed details of the helicase mechanism. PcrA and UvrD helicases have been shown to be functional as monomers, challenging previous suggestions that all helicases are required to be oligomeric.
P, Soultanas, D B, Wigley
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Mechanochemistry of T7 DNA Helicase

Journal of Molecular Biology, 2005
The bacteriophage T7 helicase is a ring-shaped hexameric motor protein that unwinds double-stranded DNA during DNA replication and recombination. To accomplish this it couples energy from the nucleotide hydrolysis cycle to translocate along one of the DNA strands.
Jung-Chi, Liao, Yong-Joo, Jeong, Dong-Eun, Kim, Smita S, Patel, George, Oster   +4 more
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Efficient Unwinding of Triplex DNA by a DNA Helicase

Biochemical and Biophysical Research Communications, 1994
Sequence specific triple helix formation shows promise as a strategy for gene-specific inhibition of gene expression by blocking promoters or enhancers. Therefore, it is important to understand how this unusual structure affects DNA metabolic processes other than transcription.
I P, Maine, T, Kodadek
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RECQ DNA Helicases and Osteosarcoma

2014
The RECQ family of DNA helicases is a conserved group of enzymes that are important for maintaining genomic integrity. In humans, there are five RECQ helicase genes, and mutations in three of them-BLM, WRN, and RECQL4-are associated with the genetic disorders Bloom syndrome, Werner syndrome, and Rothmund-Thomson syndrome (RTS), respectively ...
Linchao, Lu, Weidong, Jin, Hao, Liu, Lisa L, Wang   +3 more
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Further characterization of DNA helicase activity of mouse DNA-dependent adenosine triphosphatase B (DNA helicase B)

Biochemistry, 1988
The DNA helicase activity of DNA-dependent ATPase B purified from mouse FM3A cells [Seki, M., Enomoto, T., Hanaoka, F., & Yamada, M. (1987) Biochemistry 26, 2924-2928] has been further characterized. The helicase activity was assayed with partially duplex DNA substrates in which oligonucleotides to be released by the enzyme were radiolabeled ...
M, Seki, T, Enomoto, J, Yanagisawa, F, Hanaoka, M, Ui   +4 more
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Enhancing helicase-dependent amplification by fusing the helicase with the DNA polymerase

Gene, 2008
In this study, we have engineered a new bifunctional protein named "helimerase", by physically linking Thermoanaerobacter tengcongensis UvrD helicase (TteUvrD) and Bacillus stearothermophilus DNA polymerase I Large Fragment (Bstpol) using a coiled-coil.
Aurélie, Motré, Ying, Li, Huimin, Kong
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DNA HELICASES

Annual Review of Biochemistry, 1990
S W, Matson, K A, Kaiser-Rogers
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[DNA helicases and human diseases].

Medecine sciences : M/S, 2006
DNA helicases are molecular motors that catalyse the unwinding of energetically unstable structures into single strands and have therefore an essential role in nearly all metabolism transactions. Defects in helicase function can result in human syndromes in which predisposition to cancer and genomic instability are common features.
Uhring, Muriel, Poterszman, Arnaud
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Functions of DNA Helicases in the DNA Metabolism of Escherichia Coli

1984
DNA helicases catalyze the separation of double-stranded DNA into single strands using the energy of ATP hydrolysis. The four helicases which have been found in Escherichia coli are listed in Table 1. These enzymes are the helicases I, II, III and the helicase specified by the rep gene.
Abdel-Monem, M., Arthur , H., Benz, I., Hoffmann-Berling, H., Reygers, U., Seiter, A., Taucher-Scholz, G.   +6 more
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XPB: An unconventional SF2 DNA helicase

Progress in Biophysics and Molecular Biology, 2015
XPB is a 3'-5' DNA helicase belonging to the superfamily 2 (SF2) of helicases. XPB is an essential core subunit of the eukaryotic basal transcription factor complex TFIIH which plays a dual role in transcription and DNA repair: 1) to facilitate the melting of the promoter during the initiation of RNA polymerase II transcription; 2) to unwind double ...
Li, Fan, Kevin T, DuPrez
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