Results 201 to 210 of about 1,489,376 (287)
This graphical abstract illustrates the complete translational pipeline of Terminalia arjuna in modern phytomedicine and functional food development. It is rich in key bioactive compounds like arjunolic acid, arjungenin, flavonoids, and tannins which serve as the foundation for the plant's versatile medicinal uses and offers broad therapeutic benefits ...
Ishani Banerjee +5 more
wiley +1 more source
Two novel lytic Enterobacter phages, HHH and RZH, displayed targeted antibiofilm activity against MDR Enterobacter cloacae complex biofilms when combined with EDTA. Activity was strongest within a narrow low‐millimolar EDTA window, reducing biofilm biomass and viable burden, while higher EDTA concentrations shifted the interaction towards antagonism ...
Kashif Haq +4 more
wiley +1 more source
Structural and functional perspectives on DEAD-box RNA helicases in the rubber tree cold stress response. [PDF]
Gao B, Xiao M, Mao C, Liu J.
europepmc +1 more source
Epitranscriptomics is understudied in bacteria but has the ability to modulate antimicrobial resistance, virulence and pathogenicity. Pitt et al. implement two cutting‐edge techniques: CRISPR interference and Nanopore direct RNA sequencing along with functional assays to study RNA modifications in Escherichia coli.
Miranda E. Pitt +8 more
wiley +1 more source
Intrinsic Disorder as a New Frontier in Antimicrobial Resistance and Bacterial Fitness
The works examines the link between intrinsic disorder in bacterial protein structure, and bacterial function, and antimicrobial resistance. It highlights how flexible, disordered proteins support secretion, stress responses, desiccation protection, and virulence, while also suggesting that these adaptable regions may provide novel targets for ...
Jack O' Callaghan +3 more
wiley +1 more source
Clinical and Molecular Features of BAP1‐Mutated Meningiomas: Case Series
ABSTRACT BRCA1‐associated protein 1 (BAP1)‐deficient meningiomas represent a clinically and molecularly distinct subgroup with variable histology and aggressive behavior that may not be fully captured by current grading criteria. The clinical spectrum of BAP1 alterations in meningiomas, including both somatic and germline contexts, remains incompletely
Ivan Pradilla +7 more
wiley +1 more source
Discovery of the order '<i>Quisvirales</i>' redefines the evolution of RNA replication and transcription in the phylum <i>Pisuviricota</i>. [PDF]
Gorbalenya AE +3 more
europepmc +1 more source
Maturation‐Dependent Constraints in the Ability of Human Monocytes to Initiate Trained Immunity
In premature infants, innate immune memory may serve as an important compensatory mechanism for the underdeveloped adaptive immune system. However, monocytes derived from prematurely born individuals display abnormal metabolic and insufficient transcriptomic responses to β‐glucan‐induced training.
Michael Eigenschink +10 more
wiley +1 more source
A conserved mechanism for dimerization and activation of superfamily 1A UvrD-family helicases. [PDF]
Nguyen B +4 more
europepmc +1 more source
Targeting the DNA Damage Response in Cancer
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao +4 more
wiley +1 more source

