Results 181 to 190 of about 47,217 (278)

Dna2 initiates resection at clean DNA double-strand breaks [PDF]

open access: yes, 2017
Hunter, Tony   +4 more
core   +2 more sources

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

open access: yesVeterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri   +13 more
wiley   +1 more source

Massive contractions of myotonic dystrophy type 2-associated CCTG tetranucleotide repeats occur via double-strand break repair with distinct requirements for DNA helicases. [PDF]

open access: yesG3 (Bethesda)
Papp D   +11 more
europepmc   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

open access: yesInternational Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte   +10 more
wiley   +1 more source

Clinical Insights From a Case of Sifrim‐Hitz‐Weiss Syndrome With a CHD4 Variant: Expanding the Phenotypic Spectrum and Its Response to Growth Hormone Therapy

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1403-1410, June 2026.
ABSTRACT To enhance clinicians' understanding of Sifrim‐Hitz‐Weiss syndrome (SIHIWES), this study investigated the clinical phenotypes, genetic characteristics, and response to growth hormone therapy in a patient. A case of a patient with global developmental delay and distinctive facial features is presented.
Jianmei Zhang   +6 more
wiley   +1 more source

Direct Fluorescent Imaging of Translocation and Unwinding by Individual DNA Helicases. [PDF]

open access: yesMethods Enzymol, 2016
Pavankumar TL   +2 more
europepmc   +1 more source

Association mapping for hop cone chemistry and morphology identifies natural beneficial allele stacks

open access: yesThe Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Efforts are underway to increase the efficiency and precision of selection hop (Humulus lupulus L.) breeding using genomics. Little is known, however, about the genetic control of important traits like α‐and β‐acids contents, oil content, and cone morphological characteristics, all of which play an important role in determining the utility and
Shaun J. Clare   +2 more
wiley   +1 more source

Genetic identification and characterization of novel loci for flag leaf morphology traits in Chinese endemic wheat

open access: yesThe Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Flag leaf morphology (FLM) is a critical determinant of wheat (Triticum aestivum L.) photosynthetic efficiency and grain yield. Chinese endemic wheat, a unique genetic reservoir formed by long‐term adaptation to diverse and heterogeneous environments in China, harbors abundant, untapped allelic variation for traits related to environmental ...
Md Nahibuzzaman Lohani   +12 more
wiley   +1 more source

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