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Shuttling of RecQ helicase HIM-6 coordinates iterative cycle of unwinding, pulling, and backsliding. [PDF]
Nucleic Acids ResLe ST, Lee SW, Kim C, Kim H, Ahn B.
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DNA helicases: ‘inching forward’
Current Opinion in Structural Biology, 2000Recently determined crystal structures of PcrA helicase complexed with a DNA substrate have revealed details of the helicase mechanism. PcrA and UvrD helicases have been shown to be functional as monomers, challenging previous suggestions that all helicases are required to be oligomeric.
P, Soultanas, D B, Wigley
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Mechanochemistry of T7 DNA Helicase
Journal of Molecular Biology, 2005The bacteriophage T7 helicase is a ring-shaped hexameric motor protein that unwinds double-stranded DNA during DNA replication and recombination. To accomplish this it couples energy from the nucleotide hydrolysis cycle to translocate along one of the DNA strands.
Jung-Chi, Liao +4 more
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2018
This chapter discusses the application of single-molecule approaches in the study of helicases. It describes the main helicase families and possible mechanisms of their action, and the problems of bulk experiments on helicases resulting from rehybridization of unwound strands in the wake of the enzyme; this problem is absent for RecBCD, a helicase ...
David Bensimon +4 more
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This chapter discusses the application of single-molecule approaches in the study of helicases. It describes the main helicase families and possible mechanisms of their action, and the problems of bulk experiments on helicases resulting from rehybridization of unwound strands in the wake of the enzyme; this problem is absent for RecBCD, a helicase ...
David Bensimon +4 more
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RECQ DNA Helicases and Osteosarcoma
2020The RECQ family of DNA helicases is a conserved group of enzymes that plays an important role in maintaining genomic stability. Humans possess five RECQ helicase genes, and mutations in three of them - BLM, WRN, and RECQL4 - are associated with the genetic disorders Bloom syndrome, Werner syndrome, and Rothmund-Thomson syndrome (RTS), respectively ...
Linchao, Lu, Weidong, Jin, Lisa L, Wang
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Inhibition of DNA helicases with DNA-competitive inhibitors
Bioorganic & Medicinal Chemistry Letters, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sandy, Dubaele +4 more
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RECQ DNA Helicases and Osteosarcoma
2014The RECQ family of DNA helicases is a conserved group of enzymes that are important for maintaining genomic integrity. In humans, there are five RECQ helicase genes, and mutations in three of them-BLM, WRN, and RECQL4-are associated with the genetic disorders Bloom syndrome, Werner syndrome, and Rothmund-Thomson syndrome (RTS), respectively ...
Linchao, Lu +3 more
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