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Rare genetic diseases associated with G-quadruplex-induced replication stress. [PDF]
Commun BiolHerr LM +6 more
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Structure, Function and Inhibition of Helicases Involved in Virus Infection. [PDF]
BiomoleculesSarvari G, Boehr DD.
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The role of non-coding RNAs in regulating R-loop dynamics in cancer: Mechanisms and therapeutic implications. [PDF]
Acta Pharm Sin BZheng S +5 more
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Inhibition of DNA helicases with DNA-competitive inhibitors
Bioorganic & Medicinal Chemistry Letters, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sandy, Dubaele +4 more
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Functions of DNA Helicases in the DNA Metabolism of Escherichia Coli
, 1984 DNA helicases catalyze the separation of double-stranded DNA into single strands using the energy of ATP hydrolysis. The four helicases which have been found in Escherichia coli are listed in Table 1. These enzymes are the helicases I, II, III and the helicase specified by the rep gene.
Abdel-Monem, M. +6 more
openaire +4 more sources
[DNA helicases and human diseases].
Medecine sciences : M/S, 2006 DNA helicases are molecular motors that catalyse the unwinding of energetically unstable structures into single strands and have therefore an essential role in nearly all metabolism transactions. Defects in helicase function can result in human syndromes in which predisposition to cancer and genomic instability are common features.
Uhring, Muriel, Poterszman, Arnaud
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RECQ DNA Helicases and Osteosarcoma
2020The RECQ family of DNA helicases is a conserved group of enzymes that plays an important role in maintaining genomic stability. Humans possess five RECQ helicase genes, and mutations in three of them - BLM, WRN, and RECQL4 - are associated with the genetic disorders Bloom syndrome, Werner syndrome, and Rothmund-Thomson syndrome (RTS), respectively ...
Linchao, Lu, Weidong, Jin, Lisa L, Wang
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Mycobacterium tuberculosis UvrD1 and UvrD2 helicases unwind G-quadruplex DNA
FEBS Journal, 2019 Unresolved G-quadruplex (G4) DNA secondary structures impede DNA replication and can lead to DNA breaks and to genome instability. Helicases are known to unwind G4 structures and thereby facilitate genome duplication.
Tias Saha +2 more
exaly +2 more sources
2018
This chapter discusses the application of single-molecule approaches in the study of helicases. It describes the main helicase families and possible mechanisms of their action, and the problems of bulk experiments on helicases resulting from rehybridization of unwound strands in the wake of the enzyme; this problem is absent for RecBCD, a helicase ...
David Bensimon +4 more
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This chapter discusses the application of single-molecule approaches in the study of helicases. It describes the main helicase families and possible mechanisms of their action, and the problems of bulk experiments on helicases resulting from rehybridization of unwound strands in the wake of the enzyme; this problem is absent for RecBCD, a helicase ...
David Bensimon +4 more
openaire +1 more source
DNA helicases: ‘inching forward’
Current Opinion in Structural Biology, 2000Recently determined crystal structures of PcrA helicase complexed with a DNA substrate have revealed details of the helicase mechanism. PcrA and UvrD helicases have been shown to be functional as monomers, challenging previous suggestions that all helicases are required to be oligomeric.
P, Soultanas, D B, Wigley
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