Structure/function studies of the NAD+-dependent DNA ligase from the poly-extremophile Deinococcus radiodurans reveal importance of the BRCT domain for DNA binding. [PDF]
Extremophiles, 2023 Fernandes A +3 more
europepmc +1 more source
Biochemical properties of a high fidelity DNA ligase from Thermus species AK16D [PDF]
, 1999 Janelle Tong, Weiguo Cao, Francis Barany
openalex +1 more source
A novel assay for DNA ligase [PDF]
Nucleic Acids Research, 1991 Jamboor K. Vishwanatha, John Goodchild
openaire +3 more sources
Advanced Science, EarlyView.This study uncovers STAT6‐driven pulmonary fibrosis (PF) via suppression of PRKN‐mediated airway epithelial mitophagy, triggering mitochondrial dysfunction and ferroptosis. Rifabutin is identified as a potent STAT6 inhibitor that effectively reverses fibrotic progression. These findings reveal the STAT6‐PRKN axis as a pathogenic regulator and provide a
Youjing Yang +7 more
wiley +1 more source
Catalytically inactive DNA ligase IV promotes DNA repair in living cells. [PDF]
Nucleic Acids Res, 2022 Goff NJ +10 more
europepmc +1 more source
Thermodynamics of Human DNA Ligase I Trimerization and Association with DNA Polymerase β [PDF]
, 1998 Emilios K. Dimitriadis +6 more
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Advanced Science, EarlyView.The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu +8 more
wiley +1 more source
Peptide‐Based Biomaterials as a Promising Tool for Cancer Radiotherapy
Advanced Science, EarlyView.This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Qian Wang, Xinhui Chu, Jianfeng Liu
wiley +1 more source
Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1. [PDF]
Sci Rep, 2023 Bhandari SK +6 more
europepmc +1 more source
Macromolecular crowding allows blunt-end ligation by DNA ligases from rat liver or Escherichia coli.
, 1983 Steven B. Zimmerman, Barbara H. Pheiffer
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