Cognate base-pair selectivity of hydrophobic unnatural bases in DNA ligation by T4 DNA ligase. [PDF]
Biopolymers, 2021 Kimoto M +4 more
europepmc +2 more sources
Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps. [PDF]
Mol Cell, 2021 Paes Dias M +20 more
europepmc +3 more sources
Biological Activities of Galanthus fosteri Extracts: First Demonstration of the Interaction between Chlorogenic Acid and DNA Ligase by Molecular Docking. [PDF]
ACS OmegaKorcan SE +4 more
europepmc +3 more sources
Molecular Microbiology, 2001 DNA ligases join breaks in the phosphodiester backbone of DNA molecules and are used in many essential reactions within the cell. All DNA ligases follow the same reaction mechanism, but they may use either ATP or NAD+ as a cofactor. All Bacteria (eubacteria) contain NAD+‐dependent DNA ligases, and the uniqueness of these enzymes to Bacteria makes them ...
Wilkinson, A, Day, J, Bowater, R
openaire +3 more sources
Escherichia coli DNA ligase B may mitigate damage from oxidative stress. [PDF]
PLoS ONE, 2017 Escherichia coli encodes two DNA ligases, ligase A, which is essential under normal laboratory growth conditions, and ligase B, which is not. Here we report potential functions of ligase B.
Truston J Bodine +6 more
doaj +1 more source
Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair
Nature Communications, 2022 Ligase I seals two ends of DNA during DNA repair and replication. Here — solving structures of Ligase I with imperfect DNA harboring mismatches incorporated by DNA polymerase — the authors reveal how the repair proteins maintain fidelity at final ...
Qun Tang +3 more
doaj +1 more source
High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication
Nature Communications, 2021 DNA ligase 1 (LIG1) finalizes eukaryotic nuclear DNA synthesis by sealing Okazaki fragments using DNA end-joining reactions. Here the authors, by studying an engineered low-fidelity LIG1, reveal that LIG1 is a highly accurate DNA ligase in vivo.
Jessica S. Williams +5 more
doaj +1 more source
SUMO chain formation is required for response to replication arrest in S. pombe [PDF]
, 2009 SUMO is a ubiquitin-like protein that is post-translationally attached to one or more lysine residues on target proteins. Despite having only 18% sequence identity with ubiquitin, SUMO contains the conserved betabetaalphabetabetaalphabeta fold present in
A Gorg +41 more
core +17 more sources
PLoS Genetics, 2023 The tumor suppressor BRCA1-BARD1 complex regulates many cellular processes; of critical importance to its tumor suppressor function is its role in genome integrity.
Qianyan Li +4 more
doaj +1 more source
Thermostable DNA ligases from hyperthermophiles in biotechnology
Frontiers in Microbiology, 2023 DNA ligase is an important enzyme ubiquitous in all three kingdoms of life that can ligate DNA strands, thus playing essential roles in DNA replication, repair and recombination in vivo.
Jingru Shi +3 more
doaj +1 more source