Results 201 to 210 of about 2,162,763 (370)
Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration
Advanced Science, EarlyView.This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong +17 more
wiley +1 more source
DNA Linear Block Codes: Generation, Error-detection and Error-correction of DNA Codeword [PDF]
International Journal of Bioinformatics Intelligent Computing.
2022;1(2):103-126, 2019 In modern age, the increasing complexity of computation and communication technology is leading us towards the necessity of new paradigm. As a result, unconventional approach like DNA coding theory is gaining considerable attention. The storage capacity, information processing and transmission properties of DNA molecules stimulate the notion of DNA ...
arxiv
Mismatch and blunt to protruding-end joining by DNA ligases [PDF]
, 1987 Ryszard Wiaderkiewicz +1 more
openalex +1 more source
Advanced Science, EarlyView.This study uncovers the activation, heterogeneity, and regulatory roles of pancreatic stellate cells (PSCs) at single‐cell and spatial levels. It further identifies PLXDC1+ PSCs near aggressive LRRC15+ cancer‐associated myofibroblasts and SPP1+ macrophages, forming a desmoplastic and immunosuppressive tumor niche that promotes CD8+ T cell exhaustion ...
Yanhua Du +12 more
wiley +1 more source
The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex
Cell Reports, 2019 Summary: Adenoviruses (AdVs) cause respiratory, ocular, and gastrointestinal tract infection and inflammation in immunocompetent people and life-threatening disease upon immunosuppression.
Michael Bauer +8 more
doaj
Effect of histone H1, poly(ethyleneglycol) and DNA concentration on intermolecular and intramolecular ligation by T4 DNA ligase [PDF]
, 1988 Joëlle Sobczak‐Thépot, Michel Duguet
openalex +1 more source
COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma
Advanced Science, EarlyView.COPS5, which is overexpressed in HCC in an amplification‐ and ATF4‐dependent manner, stabilizes MK2 through deubiquitination and, in turn, induces HSPB1 activation, protecting HCC cells from ferroptosis and thus promoting sorafenib resistance and tumor progression. Abstract Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as
Ai‐Ling Luo +15 more
wiley +1 more source
Purification of HB8 DNA Ligase by Red Sepharose Chromatography [PDF]
, 1986 Miho Takahashi +2 more
openalex +1 more source