Results 201 to 210 of about 354,326 (330)

Substrate Targeting and Control of DNA Replication by the CUL4/DDB1 Ubiquitin Ligase

, 2019
Chad M. McCall
openalex   +2 more sources

Failing to Make Ends Meet: The Broad Clinical Spectrum of DNA Ligase IV Deficiency. Case Series and Review of the Literature [PDF]

, 2019
Aidé Tamara Staines Boone, Iván K. Chinn, Carmen Aláez‐Verson, Marco Antonio Yamazaki‐Nakashimada, Karol Carrillo‐Sánchez, María de la Luz Hortensia García-Cruz, M. Cecilia Poli, María Edith González Serrano, Edgar Alejandro Medina Torres, David Muzquiz Zermeño, Lisa R. Forbes, Francisco Espinosa‐Rosales, Sara Elva Espinosa‐Padilla, Jordan S. Orange, Saúl Oswaldo Lugo Reyes   +14 more
openalex   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Molecular basis for RNA discrimination by human DNA ligase 1. [PDF]

Nucleic Acids Res
Tumbale PP, Jurkiw TJ, Krahn JM, Bokil NV, Admiraal SJ, Pedersen LC, Williams JS, Kunkel TA, O'Brien PJ, Williams RS.   +9 more
europepmc   +1 more source

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing [PDF]

, 2019
Philippe Coulombe, Joëlle Nassar, Isabelle Peiffer, Slavica Stanojčić, Yvon Sterkers, Axel Delamarre, Stéphane Bocquet, Marcel Méchali   +7 more
openalex   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Crystal structure of ATP-dependent DNA ligase from Rhizobium phage vB_RleM_P10VF. [PDF]

Acta Crystallogr F Struct Biol Commun
Rothweiler U, Leiros HKS, Williamson A.
europepmc   +1 more source

DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining [PDF]

, 2017
Michael P. Conlin, Dylan A. Reid, George W. Small, Howard H. Chang, Go Watanabe, Michael R. Lieber, Dale A. Ramsden, Eli Rothenberg   +7 more
openalex   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Impact of DNA Ligase 1 Genotypes on Childhood Acute Lymphocytic Leukemia. [PDF]

In Vivo
Hsu PC, Chen CC, Tsai HW, Chang WS, Pei JS, Wang YC, Lin ML, He JL, Chen SS, Tsai CW, Bau DT.   +10 more
europepmc   +1 more source