Results 271 to 280 of about 337,826 (349)

β‐Mangostin Attenuates TET2‐Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
β‐Mangostin alleviates intervertebral disc degeneration through dual modulation of macrophage polarization and the TET2‐Prkcg axis in nucleus pulposus cells. Abstract Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the ...
Xiangzhen Kong   +15 more
wiley   +1 more source

The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling

open access: yesAdvanced Science, EarlyView.
The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu   +17 more
wiley   +1 more source

Two Forms of Mitochondrial DNA Ligase III Are Produced inXenopus laevis Oocytes [PDF]

open access: hybrid, 2001
Romina M. Perez-Jannotti   +2 more
openalex   +1 more source

A Molecular Recruitment Colocalization Platform for Visualizing Multi‐Protein Interactions and Engineering Biomolecular Condensates in Living Cells

open access: yesAdvanced Science, EarlyView.
MRC is a live‐cell method enabling visualization of protein–protein interactions and biomolecular condensates. It supports multi‐protein colocalization, binding analysis, and programmable condensate manipulation, providing a versatile platform for studying dynamic cellular organization.
Lei Peng   +8 more
wiley   +1 more source

Identification of a Mutated DNA Ligase IV Gene in the X-ray-hypersensitive Mutant SX10 of Mouse FM3A Cells [PDF]

open access: hybrid, 2001
Katsuyuki Sado   +6 more
openalex   +1 more source

Homeostasis of DNA Hemi‐Methylation in Arabidopsis through Methylation Maintenance, DNA Replication, and Nucleosome Positioning Mechanisms

open access: yesAdvanced Science, EarlyView.
In Arabidopsis, the homeostasis of full‐ and hemi‐methylation is mainly regulated by maintenance methylation. The maintenance methylation at hemi‐methylated dyads is highly efficient but the efficiency differs at euchromatic or heterochromatic regions. Nucleosomes impair the hemi‐ to full‐methylation transition. Lagged methylation maintenance after DNA
Hengye Chen, Chenhuan Xu
wiley   +1 more source

Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer

open access: yesAdvanced Science, EarlyView.
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu   +7 more
wiley   +1 more source

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