Results 71 to 80 of about 337,826 (349)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Interactome analysis and docking site prediction of DNA X-ray repair cross-complementing protein (XRCC) in Arabidopsis thaliana [PDF]

Network Biology, 2020
There are seven homologs in eukaryotic RAD51 gene family which are conserved among animals and plants, and those are RAD51, DMC1, RAD51c, XRCC3, RAD51b, RAD51d and XRCC2.
Mohamed Ragab Abdel Gawwad, Mohamed Soliman Elshikh, Haris Lokvancic   +2 more
doaj  

Case Report: Wide Spectrum of Manifestations of Ligase IV Deficiency: Report of 3 Cases

Frontiers in Immunology, 2022
DNA ligase IV deficiency is a rare autosomal recessive disorder associated with impaired DNA repair mechanisms. Most patients with DNA repair defects present with neurologic deficits, combined immunodeficiency, bone marrow failure, and/or hematologic ...
Ana Costa e Castro, Raquel Maia, Sara Batalha, João Parente Freixo, Catarina Martins, Catarina Martins, Conceição Neves, Ana Isabel Cordeiro, João Farela Neves, João Farela Neves, João Farela Neves   +10 more
doaj   +1 more source

A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. [PDF]

, 2015
The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER).
Acosta-Alvear, Diego, Mendez, Aaron S, Peschek, Jirka, Walter, Peter   +3 more
core   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

ATPase-dependent control of the Mms21 SUMO ligase during DNA repair.

PLoS Biology, 2015
Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid ...
Marcelino Bermúdez-López, Irene Pociño-Merino, Humberto Sánchez, Andrés Bueno, Clàudia Guasch, Seba Almedawar, Sergi Bru-Virgili, Eloi Garí, Claire Wyman, David Reverter, Neus Colomina, Jordi Torres-Rosell   +11 more
doaj   +1 more source

Smc5/6: a link between DNA repair and unidirectional replication? [PDF]

, 2008
Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication.
A Losada, Antony M. Carr, AR Lehmann, B Hu, D Branzei, D Ivanov, DM Sheedy, E Ampatzidou, E Unal, E Unal, EA Andrews, ES Chen, F Onoda, G De Piccoli, GJ Cost, H Morikawa, HB Lindroos, HM Verkade, I Miyabe, J Palecek, J Rouse, J Sergeant, J Torres-Rosell, J Torres-Rosell, JK Chin, Johanne M. Murray, KL Borden, KM Lee, L Strom, L Strom, MI Fousteri, MN Boddy, N Aono, PR Potts, PR Potts, PR Potts, S Pebernard, S Pebernard, SH Harvey, T de Lange, T Kobayashi, T Mengiste, T Morishita, TM Roberts, WH McDonald, WM Thorburn, X Zhao   +46 more
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

In vitro Assay to Measure DNA Polymerase β Nucleotide Insertion Coupled with the DNA Ligation Reaction during Base Excision Repair

Bio-Protocol, 2017
We previously reported that oxidized nucleotide insertion by DNA polymerase β (pol β) can confound the DNA ligation step during base excision repair (BER) (Çağlayan et al., 2017).
Melike Çağlayan, Samuel Wilson
doaj   +1 more source