Results 61 to 70 of about 145,020 (273)
A Conditional Yeast E1 Mutant Blocks the Ubiquitin–Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome [PDF]
, 2007 E1 ubiquitin activating enzyme catalyzes the initial step in all ubiquitin-dependent processes. We report the isolation of uba1-204, a temperature-sensitive allele of the essential Saccharomyces cerevisiae E1 gene, UBA1.Amerik A. Y., Babbitt S. E., Bertolaet B. L., Bertolaet B. L., Biggins S., Chen L., Cheng I. H., Ciechanover A., Deshaies R. J., Deveraux Q., Elsasser S., Elsasser S., Elsasser S., Finley D., Funakoshi M., Gandre S., Glickman M. H., Guthrie C., Haas A. L., Haracska L., Hicke L., Hofmann K., Johnson E. S., Kang Y., Kleijnen M. F., Kulka R. G., Lambertson D., Lambertson D., Lowe E. D., Madura K., McGrath J. P., Nazli Ghaboosi, Ortolan T. G., Peng J., Pickart C. M., Raasi S., Raasi S., Rao H., Raymond J. Deshaies, Richly H., Ryu K. S., Saeki Y., Saeki Y., Saeki Y., Salvat C., Schauber C., Schuberth C., Shimada K., Swanson R., Swanson R., van Nocker S., van Nocker S., Verma R., Verma R., Verma R., Walters K. J., Walters K. J., Watkins J. F., Wilkinson C.R.M., William Tansey +59 morecore +2 more sourcesBaicalein resensitizes tamoxifen‐resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia‐inducible factor‐1α
Clinical and Translational Medicine, 2021 Drug resistance is a major hurdle for the effectiveness of tamoxifen (TAM) to provide clinical benefit. Therefore, it is essential to identify a sensitizer that could be used to improve TAM efficacy in treating TAM‐resistant breast cancer.Yan Chen, Jingyu Zhang, Minqin Zhang, Yuxuan Song, Yue Zhang, Shuangqin Fan, Shuang Ren, Lingyun Fu, Nenling Zhang, Hui Hui, Xiangchun Shen +10 moredoaj +1 more sourceImpact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair [PDF]
, 2012 Microcephaly with early-onset, intractable seizures and developmental delay (MCSZ) is a hereditary disease caused by mutations in polynucleotide kinase/phosphatase (PNKP), a DNA strand break repair protein with DNA 5'-kinase and DNA 3'-phosphatase ...Alexandra K. Walker, Beckman, Bernstein, Breslin, Breslin, Brodsky, Buck, Buck, Caldecott, Caldecott, Chappell, Christopher A. Walsh, Date, Dingwall, Dobson, Edward C. Gilmore, El-Khamisy, Evans, Garces, Hsiang, Interthal, John J. Reynolds, Karimi-Busheri, Keith W. Caldecott, Koch, Kouzminova, Kuzminov, Lee, Lindahl, Loizou, McCullough, Moreira, Riballo, Segal-Raz, Shen, Sprules, Takashima, Wang, Wang, Ward, Ward, Whitehouse +41 morecore +1 more sourceAtaxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma
Haematologica, 2020
Ataxia telangiectasia mutated (ATM), a critical DNA damage sensor with protein kinase activity,is frequently altered in human cancers including mantle cell lymphoma (MCL).Aloke Sarkar, Christine M. Stellrecht, Hima V. Vangapandu, Mary Ayres, Benny A. Kaipparettu, Jun Hyoung Park, Kumudha Balakrishnan, Jared K. Burks, Tej K. Pandita, Walter N. Hittelman, Sattva S. Neelapu, Varsha Gandhi +11 moredoaj +1 more sourceAdaptive remodeling of the bacterial proteome by specific ribosomal modification regulates Pseudomonas infection and niche colonisation [PDF]
, 2016 Post-transcriptional control of protein abundance is a highly important, underexplored regulatory process by which organisms respond to their environments.A Brencic, A Rico, A Shevchenko, A Zhang, AJ Spiers, Alexandra M. Howat, BL Schneider, BR Borlee, BR Kulasekara, C Lamb, C Pesavento, C Reimmann, CD Boyd, Christopher S Hayes, CO Dimkpa, D Haas, D Yu, DC Naseby, DN Rodriguez-Navarro, E Barahona, E Barahona, E Burrowes, E Trampari, Eleftheria Trampari, F Harrison, G Desnoyers, G Mulley, G Zhao, Gerhard Saalbach, GL Winsor, H Kulasakara, I Kuiper, I Moll, J Boch, J Timmermans, JA Moscoso, JA Vizcaino, Jacob G. Malone, JG Malone, JH Miller, JT Greenberg, JW Hickman, K Kino, K Lapouge, K Maki, K Matsumoto, K Potrykus, KH Choi, KK Swinger, Lucia Grenga, M Christen, M Frederix, M Gao, M Jozefczak, M Lindeberg, M Starkey, MC Whalen, MH Rau, MV Nesterchuk, MW Silby, NM Wilf, P Sobrero, R Hengge, R Little, Richard H. Little, RP Ryan, S Heeb, S Lindenberg, Sebastian Pfeilmeier, SL Kuchma, T Afonyushkin, T Moller, T Morita, TS Walker, TT Hoang, TW Lynch, U Jenal, UA Bommer, VK Ramachandran, WC Winkler, WK Kang, WM Konyecsni, XF Xin, Y Irie +83 morecore +3 more sourcesDNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism
Epigenetics & Chromatin, 2019 Background The stability of p53 is mainly controlled by ubiquitin-dependent degradation, which is triggered by the E3 ubiquitin ligase MDM2. The chromatin modifier lymphoid-specific helicase (LSH) is essential for DNA methylation and cancer progression ...Ling Chen, Ying Shi, Na Liu, Zuli Wang, Rui Yang, Bin Yan, Xiaoli Liu, Weiwei Lai, Yating Liu, Desheng Xiao, Hu Zhou, Yan Cheng, Ya Cao, Shuang Liu, Zanxian Xia, Yongguang Tao +15 moredoaj +1 more sourceEvaluation of DNA primase DnaG as a potential target for antibiotics [PDF]
, 2014 Mycobacteria contain genes for several DNA-dependent RNA primases, including dnaG, which encodes an essential replication enzyme that has been proposed as a target for antituberculosis compounds.Aidan Doherty, Aneta Kuron, Anna Brzostek, Aravind, Bartlett, Biswas, Bozena Dziadek, Brzostek, Centers for Disease Control and Prevention, Chauhan, Ciarrocchi, Collins, Corn, Della, Draper, Dwivedi, Dye, Dziadek, Frick, Gengenbacher, Griep, Iyer, Jaroslaw Dziadek, Klann, Korycka-Machala, Kuchta, Lao-Sirieix, Lao-Sirieix, Lehman, Livak, Malgorzata Korycka-Machala, Marcin Nowosielski, Modrich, Parish, Pawelczyk, Pitcher, Pitcher, Pitcher, Raviglione, Sambrook, Snapper, Srivastava, Swart, Trias, Velayati, Weller, Weller, Zhang +47 morecore +1 more sourceGinsenoside Re Treatment Attenuates Myocardial Hypoxia/Reoxygenation Injury by Inhibiting HIF-1α Ubiquitination
Frontiers in Pharmacology, 2020 Previous studies have shown an attenuating effect of ginsenoside Re on myocardial injury induced by hypoxia/reoxygenation (H/R). However, the underlying mechanism remains unclear.Huiyuan Sun, Huiyuan Sun, Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Jianwei Li, Yang Li, Hua Qu, Ruikai Du, Ying Zhang, Feng Xu, Yuheng Li, Caizhi Liu, Guohui Zhong, Shuai Liang, Zizhong Liu, Xingcheng Gao, Xiaoyan Jin, Yingxian Li, Dazhuo Shi +19 moredoaj +1 more sourceQuantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time [PDF]
, 2003 DNA single strand breaks (SSBs) are one of the most frequent DNA lesions in genomic DNA generated either by oxidative stress or during the base excision repair pathways.Asakura, Shoji, Caldecott, Keith W, de Murcia, Gilbert, Hester, Susan D, Nakamura, Jun, Swenberg, James A +5 morecore +3 more sources
