Results 121 to 130 of about 2,144,804 (323)

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science, EarlyView.
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

Smurfs in Protein Homeostasis, Signaling, and Cancer

Frontiers in Oncology, 2018
Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade essential for normal cellular functions and homeostasis maintenance.
Praveen Koganti, Gal Levy-Cohen, Michael Blank   +2 more
doaj   +1 more source

Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity. [PDF]

Nucleic Acids Res, 2023
McNally JR, Ames AM, Admiraal SJ, O'Brien PJ.   +3 more
europepmc   +1 more source

Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection [PDF]

, 2016
Lorenza P. Ferretti, Sarah-Felicitas Himmels, Anika Trenner, Christina Walker, Christine von Aesch, Aline Eggenschwiler, Olga Murina, Radoslav I. Enchev, Matthias Peter, Raimundo Freire, Antônio Porro, Alessandro A. Sartori   +11 more
openalex   +1 more source

SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination [PDF]

, 2022
Yongjuan Guan, Huijuan Lin, N. Adrian Leu, Gordon Ruthel, Serge Y. Fuchs, Luca Busino, Mengcheng Luo, P. Jeremy Wang   +7 more
openalex   +1 more source

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Ligation reaction specificities of an NAD+-dependent DNA ligase from the hyperthermophile Aquifex aeolicus [PDF]

, 2000
Janelle Tong
openalex   +1 more source

Cofactor Binding Modulates the Conformational Stabilities and Unfolding Patterns of NAD+-dependent DNA Ligases from Escherichia coli and Thermus scotoductus*

Journal of Biological Chemistry, 2003
DNA ligases are important enzymes required for cellular processes such as DNA replication, recombination, and repair. NAD+-dependent DNA ligases are essentially restricted to eubacteria, thus constituting an attractive target in the development of novel ...
D. Georlette, V. Blaise, C. Dohmen, F. Bouillenne, Benjamin Damien, E. Depiereux, C. Gerday, V. Uversky, G. Feller   +8 more
semanticscholar   +1 more source

Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions

Advanced Science, EarlyView.
Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley   +1 more source

E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis [PDF]

, 2016
Leena Ackermann, Michael J. Schell, Wojciech Pokrzywa, Éva Kevei, Anton Gartner, Björn Schumacher, Thorsten Hoppe   +6 more
openalex   +1 more source