Results 121 to 130 of about 77,898 (323)
Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. [PDF]
, 2016 Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1.
Chen, Shu-Ching +7 more
core +1 more source
Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis
Advanced Science, EarlyView.Uncovering distinct plasma cfmtDNA breakage patterns opens new frontiers for early sepsis detection and prognosis. Unique cleavage hotspots in RNR2 and COX2 regions outperform traditional biomarkers, while mechanistic insights suggest bacterial endonuclease involvement.
Haitang Liao +13 more
wiley +1 more source
Sealing of gaps in duplex DNA by T4 DNA ligase
Nucleic Acids Research, 1982 Single-strand gaps in DNA molecules were found to be a substrate for T4 DNA ligase. Sealing of the gaps was optimal at the same conditions as ligation of blunt-ended DNA molecules. Spermidine at a concentration of 2 mM stimulated the ligation of gaps, as well as the joining of DNA molecules with cohesive and blunt ends.
Göran Magnusson, Stefan Nilsson
openaire +4 more sources
Advanced Science, EarlyView.This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz +14 more
wiley +1 more source
Smurfs in Protein Homeostasis, Signaling, and Cancer
Frontiers in Oncology, 2018 Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade essential for normal cellular functions and homeostasis maintenance.
Praveen Koganti +2 more
doaj +1 more source
Mismatch discrimination and sequence bias during end-joining by DNA ligases. [PDF]
Nucleic Acids Res, 2022 Bilotti K +5 more
europepmc +1 more source
Advanced Science, EarlyView.This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni +12 more
wiley +1 more source
How SUMOylation Fine-Tunes the Fanconi Anemia DNA Repair Pathway
Frontiers in Genetics, 2016 Fanconi Anemia (FA) is a rare human genetic disorder characterized by developmental defects, bone marrow failure and cancer predisposition, primarily due to a deficiency in the repair of DNA interstrand crosslinks (ICLs).
Kate eColeman, Tony T Huang
doaj +1 more source
Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity. [PDF]
Nucleic Acids Res, 2023 McNally JR +3 more
europepmc +1 more source
Patterns and Processes of Genomic Evolution Inferred From the Ten Smallest Vertebrate Genomes
Advanced Science, EarlyView.By integrating phylogenetic relationships derived from nuclear DNA with population genetic analyses across ten pufferfish species, the genetic differentiation mechanisms underpinning the radiative speciation of the most compact vertebrate genomes has elucidated.
Kaiqiang Liu +22 more
wiley +1 more source