Results 121 to 130 of about 26,913 (206)
Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies
Annals of Neurology, EarlyView.Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel +10 more
wiley +1 more source
Angewandte Chemie, EarlyView.Die stark negativ geladenen Phosphodiestergruppen von Nukleinsäuren und zyklischen (Di‐)Nukleotiden interagieren häufig mit Aminosäuren, die polare oder positiv geladene Seitenketten enthalten. Aufgrund der Ladungsabstoßung mit ihren negativ geladenen Carboxylatgruppen enthaltenden Seitenketten gelten Glutamat und Aspartat generell als ungeeignet für ...
Konstantin Neißner +5 more
wiley +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Angewandte Chemie, EarlyView.Natürliche Kombinatorik: Die evolutionäre Rekombination und Anpassung von drei cyanobakteriellen Biosynthese‐Genclustern führte zur Entstehung von Minutumamiden, einer neuen Familie von Peptid‐Polyketid‐Hybriden. Mittels retro‐evolutionärer Analyse gelang die Entdeckung des Nostopeptolids KVJ3, einem evolutionären Vorfahren, der die Biosynthese von ...
Keishi Ishida +6 more
wiley +1 more source
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
Update: Enzymatische Synthese für industrielle Anwendungen
Angewandte Chemie, EarlyView.Die Biokatalyse hat sich zu einer nachhaltigen und wettbewerbsfähigen Alternative zur herkömmlichen chemischen Synthese entwickelt und ermöglicht die enzymbasierte Herstellung nicht nur von chemischen Grundstoffen, sondern auch von (nicht natürlichen) Aminosäuren, (seltenen) Zuckern und synthetischen Nukleotiden.
Thomas Bayer +4 more
wiley +1 more source
Ibrain, EarlyView., 2023 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. Leucine‐rich repeats and sterility α mutations in motif 1 (LRSAM1) has been proven to be involved in the pathogenesis of ALS.
Ji‐Yao Qin +6 more
wiley +1 more source
Angewandte Chemie International Edition, EarlyView.The highly negatively charged phosphodiester groups of nucleic acids and cyclic (di‐)nucleotides often interact with amino acids containing polar or positively charged sidechains. Due to charge repulsion with their negatively charged carboxylate groups in their side chains, glutamate and aspartate are considered to be detrimental to such interactions ...
Konstantin Neißner +5 more
wiley +1 more source
Angewandte Chemie International Edition, EarlyView.Natural combinatorics: Evolutionary mixing and matching of three cyanobacterial biosynthetic gene clusters resulted in the emergence of minutumamides, a novel family of peptide‐polyketide hybrids. Retro‐evolutionary analysis led to the discovery of nostopeptolide KVJ3, an evolutionary ancestor that links nostopeptolide and minutumamide biosynthesis and
Keishi Ishida +6 more
wiley +1 more source