Results 251 to 260 of about 77,898 (323)

RING‐Between‐RING‐Type E3 Ligase Ariadne‐Like Protein 8 Negatively Regulates Plant Virus Infection by Targeting a Viral Movement Protein

Advanced Science, EarlyView.
The plant RING‐between‐RING (RBR)‐type E3 ligase, Ariadne‐like protein 8 (ARI8), ubiquitinates and degrades a viral movement protein, restricting virus spread. ARI8 also inhibits other triple gene block 1 (TGB1)‐containing viruses, revealing a broad‐spectrum antiviral role.
Wenli Li, Chenchen Zhong, Jiangning Duan, Changyi Zhan, Zhaolei Li, Xinyu Zhang, Dingliang Zhang, Deshui Liu, Zhiyan Wen, Xiaofei Zhao, Meng Yang, Dawei Li, Yongliang Zhang   +12 more
wiley   +1 more source

Methods to accelerate PROTAC drug discovery. [PDF]

Biochem J
Osman J, Thompson PE, Jörg M, Scanlon MJ.   +3 more
europepmc   +1 more source

Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends

, 2000
S. A. Nick McElhinny, C. M. Snowden, J. McCarville, D. A. Ramsden   +3 more
openalex   +2 more sources

WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism [PDF]

, 2020
Abe, T., Furuya, K., Higami, Y., Hoshino, S., Kawabe, H., Kobayashi, M., Konno, R., Miura, K., Mizunoe, Y., Nakagawa, Y., Nakamura, T., Okita, N., Sudo, Y., Tagawa, R., Wakasawa, H.   +14 more
core   +1 more source

DNA‐Based Hydrogels for Musculoskeletal Reconstruction: Harnessing Dynamic Programmability and Multimodal Therapeutic Integration

Advanced Science, EarlyView.
DNA‐based hydrogels serve dual roles as structural scaffolds and therapeutic platforms, offering innovative solutions for musculoskeletal regeneration with multifunctional abilities. Abstract Musculoskeletal disorders, including bone fractures, osteoarthritis, and muscle injuries, represent a leading cause of global disability, revealing the urgency ...
Ruijianghan Shi, Huilu Zhan, Shan Jiang, Kaili Lin, Changyong Yuan   +4 more
wiley   +1 more source

A new era in cancer therapy: targeting the Proteasome-Bcl-2 axis. [PDF]

J Exp Clin Cancer Res
Soni S, Anang V, Zhao Y, Horowitz JC, Nho RS, Mebratu YA.   +5 more
europepmc   +1 more source

Mechanism of Lenvatinib Resistance via Exosomal miRNA‐132/Nrf2 Axis in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
Exosomal miRNA‐132 from LVT‐res HCC cells activated Nrf2 expression through the PTEN/GSK3β pathway in recipient cells. This cascade could induce drug resistance in non‐resistant HCC cells in the TME. ABSTRACT Introduction Lenvatinib is a multiple receptor tyrosine kinase inhibitor and a first‐line targeted therapy for hepatocellular carcinoma (HCC ...
Chie Takasu, Chiharu Nakasu, Yu Saito, Yuji Morine, Tetsuya Ikemoto, Shinichiro Yamada, Hiroki Teraoku, Mitsuo Shimada   +7 more
wiley   +1 more source

Reduced Pressure Ionization Enhances Native Mass Spectrometry of Proteins and Protein Complexes

Angewandte Chemie, EarlyView.
Reduced pressure for electrospray ionization of native proteins narrows peak widths and increases signal. This straightforward add‐on to existing native MS platforms improves performance in challenging buffers and enables detection of protein interactions at concentrations as low as 50 nM, without significantly disrupting structure as confirmed by ...
Jake P. Violi, Chong Zhang, William A. Donald   +2 more
wiley   +2 more sources

The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling. [PDF]

Nat Commun
Chiou LF, Droby GN, Jayaprakash D, Anand JR, Zhang X, Yang Y, Mills CA, Webb TS, Barker NK, Xie J, Wu D, Herring LE, Tomida J, Bowser JL, Vaziri C.   +14 more
europepmc   +1 more source

DNA Ligase I and Proliferating Cell Nuclear Antigen Form a Functional Complex

, 2001
Samson Tom, Leigh A. Henricksen, Min S. Park, Robert A. Bambara   +3 more
openalex   +1 more source