Results 261 to 270 of about 77,898 (323)

Joining of DNA Strands by DNA Ligase of E. coli

Cold Spring Harbor Symposia on Quantitative Biology, 1968
Carol K. Oshinsky, Martin Gellert, John W. Little, Steven B. Zimmerman   +3 more
openaire   +3 more sources

Long noncoding RNA GCH1 mediates mitophagy via the PTEN‐induced kinase 1/Parkin pathway to drive chondrocyte dysfunction and cartilage degeneration in osteoarthritis

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract illustrates the role of lncRNA‐GCH1 in regulating mitophagy and its downstream effects on chondrocyte dysfunction and cartilage degradation in osteoarthritis (OA). Elevated lncRNA‐GCH1 stabilizes PINK1 protein, enhancing mitophagy and mitochondrial turnover.
Gang Zeng, Yujun Sun, Taihe Liu, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Weidong Song, Yue Ding   +8 more
wiley   +1 more source

Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi

Angewandte Chemie, EarlyView.
Type III polyketide synthases (T3PKSs) produce diverse compounds of ecological and clinical importance. Here, the activity of 37 fungal T3PKSs was profiled, revealing unexpected products and generating several pharmaceutical precursors. The machine learning model trained on the activity data accurately extrapolates the predictions to other enzymes and ...
Nika Sokolova, Stepan S. Denisov, Thomas Hackl, Kristina Haslinger   +3 more
wiley   +2 more sources

The Roles of E3 Ubiquitin Ligases in Cerebral Ischemia-Reperfusion Injury. [PDF]

Int J Mol Sci
Li M, Yu X, Liu Q, Fang Z, Wang H.
europepmc   +1 more source

Cloning and Functional Characterization of an NAD ⁺ -Dependent DNA Ligase from Staphylococcus aureus

, 2001
Frank S. Kaczmarek, Richard P. Zaniewski, Thomas D. Gootz, Dennis E. Danley, Mahmoud N. Mansour, Matt Griffor, Ajith V. Kamath, Melissa Cronan, John Mueller, Dongxu Sun, Patrick K. Martin, Bret M. Benton, Laura McDowell, Donald Biek, Molly B. Schmid   +14 more
openalex   +1 more source

Development of an efficient mice model of cancer‐associated cardiac cachexia

Animal Models and Experimental Medicine, EarlyView.
This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong, Huiting Zheng, Teng Wu, Jing Tan, Tongsheng Huang, Conghui Shen, Yuanjun Ji, Mengying Liu, Junhong Wan, Weibin Cai   +9 more
wiley   +1 more source

Nucleic Acid‐Based Molecular Machines for Biological Applications

Advanced NanoBiomed Research, EarlyView.
Molecular machines are devices assembled from molecules with specific functions. In this review, the development of DNA nanostructures, which are then assembled into molecular machines, is summarized. Their classification and biological applications, such as biosensing, targeted therapy, and molecular circuits are introduced.
Yirong Guo, Xiaolei Zuo, Fangfei Yin
wiley   +1 more source

Pumping iron, keeping FIT: How MYB30 regulates FIT stability during plant iron deficiency. [PDF]

Plant Cell
Sun L.
europepmc   +1 more source

Deubiquitinase-Targeting Chimeras Mediated Stabilization of Tumor Suppressive E3 Ligase Proteins as a Strategy for Cancer Therapy. [PDF]

J Am Chem Soc
Chen L, Deng Z, Xiong Y, Liu J, Huang D, Wang J, Chen Y, Inuzuka H, Xie L, Chen X, Jin J, Wei W.   +11 more
europepmc   +1 more source

Pathological roles of ubiquitination and deubiquitination systems in sepsis-induced myocardial dysfunction. [PDF]

Biomol Biomed
Wang Z, Sun S, Huang L, Chen X, Xu H, Ma H, Xiao M, Wang L.   +7 more
europepmc   +1 more source