Results 281 to 290 of about 79,069 (319)

ATP‐Powered Signaling Between Artificial and Living Cells

Angewandte Chemie, EarlyView.
We introduce an ATP‐powered artificial cell platform capable of selectively and transiently releasing DNA signals to facilitate communication between artificial and living cells. By engineering these DNA signals, we achieve precise activation of cellular functions and regulated delivery in response to ATP levels.
Soumya Sethi, Charu Sharma, Andreas Walther   +2 more
wiley   +2 more sources

Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators. [PDF]

Adv Sci (Weinh)
Martínez-Cartró M, Serrano-Morrás Á, Bertran-Mostazo A, Castaño-Muñiz R, Scaffidi S, Ivanova V, Csorba N, Simon J, Ábrányi-Balogh P, Li Y, Keserü GM, Hao B, Barril X, Galdeano C.   +13 more
europepmc   +1 more source

Identifizierung eines Moleküls, das den Abbau der aktivierten Checkpoint‐Kinase‐1 auslöst und Charakterisierung der nicht‐katalytischen Funktionen von Checkpoint‐Kinase‐1 in Tumorzellen

Angewandte Chemie, EarlyView.
In Tumorzellen führt die durch HU induzierte Verlangsamung der DNA‐Replikation zur Aktivierung von CHK1 durch Autophosphorylierung, was einen Zellzyklusarrest bewirkt und die Rekrutierung des DNA‐Reparaturproteins WRN zur Förderung der DNA‐Reparatur und des Zellüberlebens ermöglicht.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Post-translational modifications of SOG1 enable dynamic control of plant DNA damage response. [PDF]

Sci Adv
Bao W, Deng Z, Zhuang S, Xu C, Yang Z, Zheng M, Zhang R, Xu M, Yan S, Wang L.   +9 more
europepmc   +1 more source

The ubiquitin-proteasome system in circadian regulation. [PDF]

Front Neurosci
Costanzo KM, Prifti MV, Todi SV, Mohan RD.   +3 more
europepmc   +1 more source

The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling. [PDF]

Nat Commun
Chiou LF, Droby GN, Jayaprakash D, Anand JR, Zhang X, Yang Y, Mills CA, Webb TS, Barker NK, Xie J, Wu D, Herring LE, Tomida J, Bowser JL, Vaziri C.   +14 more
europepmc   +1 more source

The Roles of E3 Ubiquitin Ligases in Cerebral Ischemia-Reperfusion Injury. [PDF]

Int J Mol Sci
Li M, Yu X, Liu Q, Fang Z, Wang H.
europepmc   +1 more source

Pumping iron, keeping FIT: How MYB30 regulates FIT stability during plant iron deficiency. [PDF]

Plant Cell
Sun L.
europepmc   +1 more source

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

Angewandte Chemie International Edition, EarlyView.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Research advancements regarding the relationship between FBXO2 and malignant tumors (Review). [PDF]

Mol Med Rep
Zhang J, Yang J, Zhang X, Yuan Y, Sun S, Zhang S, He J.   +6 more
europepmc   +1 more source