Results 51 to 60 of about 77,898 (323)
Mammalian DNA ligases. Biosynthesis and intracellular localization of DNA ligase I.
Journal of Biological Chemistry, 1990 Mammalian DNA ligase I is presumed to act in DNA replication. Rabbit antibodies against the homogeneous enzyme from calf thymus inhibited DNA ligase I activity and consistently recognized a single polypeptide of 125 kDa when cells from an established bovine kidney cell line (MDBK) were lysed rapidly by a variety of procedures and subjected to ...
Alan E. Tomkinson +2 more
openaire +3 more sources
The Sole DNA Ligase in Entamoeba histolytica Is a High-Fidelity DNA Ligase Involved in DNA Damage Repair [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 The protozoan parasite Entamoeba histolytica is exposed to reactive oxygen and nitric oxide species that have the potential to damage its genome. E. histolytica harbors enzymes involved in DNA repair pathways like Base and Nucleotide Excision Repair. The majority of DNA repairs pathways converge in their final step in which a DNA ligase seals the DNA ...
Elisa Azuara-Liceaga +14 more
openaire +4 more sources
Global-genome Nucleotide Excision Repair Controlled by Ubiquitin/Sumo Modifiers
Frontiers in Genetics, 2016 Global-genome nucleotide excision repair (GG-NER) prevents genome instability by excising a wide range of structurally unrelated DNA base adducts and crosslinks induced by chemical carcinogens, ultraviolet (UV) radiation or intracellular metabolic by ...
Peter eRuethemann +2 more
doaj +1 more source
DNA ligase IV syndrome; a review [PDF]
Orphanet Journal of Rare Diseases, 2016 DNA ligase IV deficiency is a rare primary immunodeficiency, LIG4 syndrome, often associated with other systemic features. DNA ligase IV is part of the non-homologous end joining mechanism, required to repair DNA double stranded breaks. Ubiquitously expressed, it is required to prevent mutagenesis and apoptosis, which can result from DNA double strand ...
Thomas Altmann +2 more
openaire +3 more sources
The COP9 SIGNALOSOME is required for postembryonic meristem maintenance in Arabidopsis thaliana [PDF]
, 2015 Cullin-RING E3 ligases (CRLs) regulate different aspects of plant development, and are activated by modification of their cullin subunit with the ubiquitin-like protein NEDD8 (NEural precursor cell expressed Developmentally Down-regulated 8) (neddylation)
Boccaccini, Alessandra +10 more
core +1 more source
Effects of DNA-binding drugs on T4 DNA ligase [PDF]
Biochemical Journal, 1990 A number of DNA intercalating and externally binding drugs have been found to inhibit nick sealing, cohesive and blunt end ligation, AMP-dependent DNA topoisomerization and EDTA-induced DNA nicking mediated by bacteriophage T4 DNA ligase. The inhibition seems to arise from drug-substrate interaction so that formation of active DNA-Mg2(+)-AMP-enzyme ...
A Montecucco +4 more
openaire +4 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Water-soluble version of SCR7-pyrazine inhibits DNA repair and abrogates tumor cell proliferation
Journal of Radiation and Cancer Research, 2019 Aim: Mammalian DNA Ligases play pivotal role in processes such as DNA replication, recombination, and repair, which qualifies them as potent therapeutic targets to eradicate cancer cells.
Monica Pandey +12 more
doaj +1 more source
Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs. [PDF]
PLoS Genetics, 2016 DNA lesions are sensed by a network of proteins that trigger the DNA damage response (DDR), a signaling cascade that acts to delay cell cycle progression and initiate DNA repair.
Zita Nagy +5 more
doaj +1 more source
Purification and Characterization of DNA Ligase III from Bovine Testes [PDF]
Journal of Biological Chemistry, 1995 Mammalian cell nuclei contain three biochemically distinct DNA ligases. In the present study we have found high levels of DNA ligase I and DNA ligase III activity in bovine testes and have purified DNA ligase III to near homogeneity. The high level of DNA ligase III suggests a role for this enzyme in meiotic recombination.
Zachary B. Mackey +7 more
openaire +3 more sources