Results 171 to 180 of about 341,127 (338)

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Effects of 5-azacytidine on methylation and expression of specific DNA sequences in C3H 10T1/2 cells.

, 1984
W.L. Wendy Hsiao, Sebastiano Gattoni‐Celli, Paul T. Kirschmeier, I. Bernard Weinstein   +3 more
openalex   +1 more source

A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with 89Zr/131I‐Labeled Tinurilimab

Advanced Science, EarlyView.
This study investigates the integrated diagnostic and therapeutic strategy utilizing 89Zr/131I‐labeled tinurilimab for the management of malignant lung nodules, with a particular focus on lung adenocarcinoma (LUAD). CEACAM6, which is highly expressed in most LUAD patients, activates the Src/FAK signaling pathway, thereby promoting cell proliferation ...
Chongyang Chen, Keying Zhu, Jing Wang, Donghui Pan, Xinyu Wang, Yuping Xu, Junjie Yan, Lizhen Wang, Min Yang   +8 more
wiley   +1 more source

Adverse maternal environment alters Oprl1 variant expression in mouse hippocampus

The Anatomical Record, Volume 306, Issue 1, Page 162-175, January 2023., 2023
Abstract An adverse maternal environment (AME) and Western diet (WD) in early life predispose offspring toward cognitive impairment in humans and mice. Cognitive impairment associates with hippocampal dysfunction. An important regulator of hippocampal function is the hippocampal Nociceptin/Orphanin FQ (N/OFQ) system. Previous studies find links between
Xingrao Ke, Yingliu Huang, Qi Fu, Amber Majnik, Venkatesh Sampath, Robert H. Lane   +5 more
wiley   +1 more source

Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA.

, 1986
Daniel Meruelo, Ruth Kornreich, Anthony Rossomando, Christine Pampeno, Aparna Boral, J L Silver, Joseph D. Buxbaum, Elisabeth H. Weiss, James J. Devlin, Andrew L. Mellor   +9 more
openalex   +1 more source

Sequence organisation in nuclear DNA from Physarum polycephalum: methylation of repetitive sequences [PDF]

, 1981
Paul A. Whittaker, A. McLachlan, Norman Hardman   +2 more
openalex   +1 more source

Paternal Obesity‐Induced H3K27me3 Elevation Leads to MANF‐Mediated Transgenerational Metabolic Dysfunction in Female Offspring

Advanced Science, EarlyView.
Paternal lifestyle and environmental exposures play a critical role in the offspring's health. The present study established a paternal obesity model and demonstrated that elevated H3K27me3 levels in sperm persist through the 8‐cell embryo stage. This epigenetic modification triggers transgenerational decrease of MANF, inducing ER stress and activating
Yajun Shi, Weisheng Li, Xi Yu, Yan Zhao, Dan Zhu, Yueyang Song, Zejun Zhao, Yannan Gu, Bin Wei, Lingjun Li, Dongyi Yu, Pengjie Zhang, Qinqin Gao, Miao Sun   +13 more
wiley   +1 more source

Perturbation of maintenance and de novo DNA methylation in vitro by UVB (280-340 nm)-induced pyrimidine photodimers. [PDF]

, 1985
Frederick F. Becker, Pamela Holton, Mathuros Ruchirawat, J Lapeyre   +3 more
openalex   +1 more source

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development

Advanced Science, EarlyView.
The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao, Tianxiang Tang, Bowen Wang, Shengfei He, Yue Zhang, Li Dong, Bo Xu, Ying Liu, Ping Zhu, Rui Guo   +9 more
wiley   +1 more source

DNA methylation pattern and restriction endonuclease accessibility in chromatin of a germ-line specific gene, the rainbow trout protamine gene [PDF]

, 1987
Geneviève P. Delcuve, James Davie
openalex   +1 more source