Results 171 to 180 of about 382,011 (287)

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

DNA methylation signatures of Life's Essential 8 and their implications for dementia. [PDF]

Alzheimers Res Ther
Lukacsovich D, Wang L, Young JI, Zhang W, Gomez L, Schmidt MA, Gardener H, Agudelo C, Dueker N, Elfassy T, Gibbs C, Scott SS, Martin ER, Kunkle BW, Chen XS, Blanton S, Rundek T, Wang L.   +17 more
europepmc   +1 more source

Differential DNA methylation in blood in nuclear genes that encode mitochondrial proteins in mild cognitive impairment and Alzheimer’s disease

Alexander E. Boruch, Andy Madrid, Ligia A. Papale, Phillip E. Bergmann, Isabelle Renteria, Samuel G. Faasen, Dane B. Cook, Reid S. Alisch, Kirk J. Hogan   +8 more
openalex   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Sjögren's patient subgroups identified through whole genome DNA methylation profiling. [PDF]

Arthritis Res Ther
Solomon O, Shiboski C, Taylor KE, Quach H, Quach D, Barcellos LF, Criswell LA.   +6 more
europepmc   +1 more source

Additional file 1: of Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data

, 2018
Nelly Olova, Felix Krueger, Simon Andrews, David Oxley, Rebecca V. Berrens, Miguel R. Branco, Wolf Reik   +6 more
openalex   +1 more source

Integrative Analyses Identify a cGAS‐STING Pathway‐Driven Signature With Context‐Dependent Roles in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Zhang et al. identify M7core, a critical cGAS‐STING pathway‐driven gene signature that is activated in most lupus patients’ blood and links to lupus disease severity, lymphopenia, and lupus nephritis. They further reveal the diagnostic and pathogenic characteristics of M7core and emphasize the importance of assessing pathway activity before initiating ...
Lele Zhang, Ming‐Ju Amy Lyu, Ze Hong, Jing Sun, Lan Guo, Jiameng Hu, Munire Maimaiti, Chenhui Li, Jinyi Song, Xiang Zhang, Huansha Yu, Chen Wang, Xuan Wang, Haiyang Hu   +13 more
wiley   +1 more source

Integrative analysis of DNA methylation and inflammatory protein biomarkers in hypertension. [PDF]

Front Immunol
Zhu M, Zhang J, Ma J, Tang X, Wang Y, Zhu D.   +5 more
europepmc   +1 more source

Additional file 1: of RnBeads 2.0: comprehensive analysis of DNA methylation data

, 2019
Fabian MĂźller, Michael Scherer, Yassen Assenov, Pavlo Lutsik, JĂśrn Walter, Thomas Lengauer, Christoph Bock   +6 more
openalex   +1 more source

Biomimetic Cell Membrane‐Coated MOFs System for Targeted Cancer Therapy

Advanced Science, EarlyView.
Biomimetic MOF‐based drug delivery nanoplatforms synthesized using liposomes or cell membranes as camouflage for multiple cancer therapeutics. ABSTRACT The integration of metal‐organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine.
Qilu Wu, Jia Song Deon Chon, Yuxiao Feng, Kang Liang, Shiming Li, Can Yang Zhang, Jun Ge   +6 more
wiley   +1 more source