Results 191 to 200 of about 382,011 (287)

DNA-methylation

, 2022
Frank Gaillard, Francesco Sciacca, Daniel Bell   +2 more
openaire   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

DNA methylation landscapes in human cells and their chromatin determinants. [PDF]

Ageing Cancer Res Treat
Cui W, Huang Z, Pfeifer GP.
europepmc   +1 more source

Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [PDF]

Natàlia Carreras-Gallo, Varun B. Dwaraka, Dereje D. Jima, David Skaar, Tavis L. Mendez, Antonio Planchart, Wanding Zhou, Randy L. Jirtle, Ryan Smith, Cathrine Hoyo   +9 more
openalex   +1 more source

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu, Mei Liu, Changxing Gao, Cheng Zhao, Feijie Zhao, Shuqing Dong, Bo Zhang, Qianmei Liu, Wenqian Zhang, Ming Zhao, Qianjin Lu   +10 more
wiley   +1 more source

DNA methylation landscape of Nautilus Pompilius. [PDF]

BMC Genomics
Wu Y, Mao F, Dang X, Zhang Z, Yu Z, Mu H, Zhang Y, Song X.   +7 more
europepmc   +1 more source

Hormone stimulation of androgen receptor mediates dynamic changes in DNA methylation patterns at regulatory elements [PDF]

, 2015
Vineet K. Dhiman, Kristopher Attwood, Moray J. Campbell, Dominic J. Smiraglia   +3 more
openalex   +1 more source

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

Genome-wide DNA methylation profiles and ribosomal DNA copy number at birth. [PDF]

Epigenetics
Barth K, Alfano R, Plusquin M, Wang C, Nawrot TS, Martens DS.   +5 more
europepmc   +1 more source

Decision letter: A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

, 2017

openalex   +1 more source