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DNA Methylation and Epigenotypes
Biochemistry (Moscow), 2005The science of epigenetics is the study of all those mechanisms that control the unfolding of the genetic program for development and determine the phenotypes of differentiated cells. The pattern of gene expression in each of these cells is called the epigenotype. The best known and most thoroughly studied epigenetic mechanism is DNA methylation, which
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2012
Cancer has been considered a genetic disease with a wide array of well-characterized gene mutations and chromosomal abnormalities. Of late, aberrant epigenetic modifications have been elucidated in cancer, and together with genetic alterations, they have been helpful in understanding the complex traits observed in neoplasia.
Gopinathan, Gokul, Sanjeev, Khosla
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Cancer has been considered a genetic disease with a wide array of well-characterized gene mutations and chromosomal abnormalities. Of late, aberrant epigenetic modifications have been elucidated in cancer, and together with genetic alterations, they have been helpful in understanding the complex traits observed in neoplasia.
Gopinathan, Gokul, Sanjeev, Khosla
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Human Genetics, 1983
Eukaryotic genomes contain 5-methylcytosine (5mC) as a rare base.5mC arises by postsynthetic modification of cytosine and occurs, at least in animals, predominantly in the dinucleotide CpG. The base is not distributed randomly in these genomes but conforms to a pattern. This pattern varies between taxa but appears to be inherited in a semi-conservative
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Eukaryotic genomes contain 5-methylcytosine (5mC) as a rare base.5mC arises by postsynthetic modification of cytosine and occurs, at least in animals, predominantly in the dinucleotide CpG. The base is not distributed randomly in these genomes but conforms to a pattern. This pattern varies between taxa but appears to be inherited in a semi-conservative
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Cancer epigenetics in clinical practice
Ca-A Cancer Journal for Clinicians, 2023Veronica Davalos, Manel Esteller
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2003
Since it was discovered, there was an increased interest in the analysis and the quantification of DNA methylation. In mammals this modification of DNA occurs mainly at cytosines in a CpG context (i.e. cytosine followed by guanine in 5’ to 3’ direction).
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Since it was discovered, there was an increased interest in the analysis and the quantification of DNA methylation. In mammals this modification of DNA occurs mainly at cytosines in a CpG context (i.e. cytosine followed by guanine in 5’ to 3’ direction).
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DNA Methylation in Ctenophores
Epigenomic regulation and dynamic DNA methylation, in particular, are widespread mechanisms orchestrating the genome operation across time and species. Whole-genome bisulfite sequencing (WGBS) is currently the only method for unbiasedly capturing the presence of 5-methylcytosine (5-mC) DNA methylation patterns across an entire genome with single ...Emily C, Dabe +2 more
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Am-bivalency towards DNA methylation
Nature Reviews Molecular Cell Biology, 2020Eytan Zlotorynski
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Dynamics and function of DNA methylation in plants
Nature Reviews Molecular Cell Biology, 2018Jian-Kang Zhu +2 more
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The diverse roles of DNA methylation in mammalian development and disease
Nature Reviews Molecular Cell Biology, 2019Déborah Bourc'his +2 more
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DNA methylation pathways and their crosstalk with histone methylation
Nature Reviews Molecular Cell Biology, 2015Steven E. Jacobsen +2 more
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