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Orchestration of DNA Methylation
2008DNA methylation plays an important role in gene regulation. In order to gain a better understanding of the rules governing this epigenetic modification, we have used microarray technology to map DNA methylation in the human genome. This analysis has helped decipher the DNA sequences involved in setting up the basic global methylation pattern in the ...
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2009
In order to maintain normal function and homeostasis, appropriate gene expression is critical in individual cells. Aberrant gene expression can induce disordered conditions. Regulation of gene expression is not fully known yet but current evidence indicates that epigenetics, a phenomenon that affects gene expression without changes in DNA base pairs (1)
Choi Sang Woon +2 more
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In order to maintain normal function and homeostasis, appropriate gene expression is critical in individual cells. Aberrant gene expression can induce disordered conditions. Regulation of gene expression is not fully known yet but current evidence indicates that epigenetics, a phenomenon that affects gene expression without changes in DNA base pairs (1)
Choi Sang Woon +2 more
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2010
Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Global changes in the epigenetic landscape are a hallmark of cancer.
Yoshihisa, Watanabe, Masato, Maekawa
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Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Global changes in the epigenetic landscape are a hallmark of cancer.
Yoshihisa, Watanabe, Masato, Maekawa
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1984
The interrelationship between sister chromatid exchange (SCE) formation and DNA methylation was studied in Chinese hamster V79 and Indian muntjac cells. A DNA methylation inhibitor, 5-azacytidine (5AzaC), induced SCEs only when it had been present in cells for at least 2 rounds of DNA replication.
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The interrelationship between sister chromatid exchange (SCE) formation and DNA methylation was studied in Chinese hamster V79 and Indian muntjac cells. A DNA methylation inhibitor, 5-azacytidine (5AzaC), induced SCEs only when it had been present in cells for at least 2 rounds of DNA replication.
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Current Opinion in Genetics & Development, 1995
Recent advances have expanded our understanding of the processes underlying the establishment, maintenance, and elaboration of DNA methylation patterns in eukaryotes. The functional significance of DNA methylation is sought in a comparison of results on a variety of epigenetic phenomena in different eukaryotes. The recent development of DNA methylation
R A, Martienssen, E J, Richards
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Recent advances have expanded our understanding of the processes underlying the establishment, maintenance, and elaboration of DNA methylation patterns in eukaryotes. The functional significance of DNA methylation is sought in a comparison of results on a variety of epigenetic phenomena in different eukaryotes. The recent development of DNA methylation
R A, Martienssen, E J, Richards
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Annals of the New York Academy of Sciences, 2004
Abstract: Early detection of cancer would facilitate better management of patients, because survival is greatly affected by stage of presentation. Circulating nucleic acids represent a biomarker that might be used in the early detection of cancer. In addition, such biomarkers could potentially be used to follow the progression of patients with cancer.
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Abstract: Early detection of cancer would facilitate better management of patients, because survival is greatly affected by stage of presentation. Circulating nucleic acids represent a biomarker that might be used in the early detection of cancer. In addition, such biomarkers could potentially be used to follow the progression of patients with cancer.
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Methyl DNA Immunoprecipitation
2009Epigenetics is the study of heritable changes in gene expression. Chromatin immunoprecipitation (ChIP) and methylation status analysis of genes have been applied to the study of epigenetic modifications, often perturbed in human cancer. ChIP is a technique allowing the analysis of the protein association with specific genomic regions in the context of ...
Juana, Magdalena, Jean-Jacques, Goval
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Methylation of DNA in Prokaryotes
1993A much wider variety of biological functions of postreplicative DNA methylation is observed in prokaryotes than in eukaryotes. In eukaryotes DNA methylation is primarily a means of the control of gene expression. Many chapters of this book are devoted to various aspects of this function. In prokaryotes, DNA methylation affects such diverse phenomena as
M, Noyer-Weidner, T A, Trautner
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Trends in Genetics, 1999
The methylation of CpG islands is often equated with transcriptional inactivity and there is overwhelming evidence that this is the case for islands located in gene promoters. Such methylation is probably part of a mechanism to permanently silence the activities of genes, including those on the inactive X chromosome. Not all CpG islands and methylation
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The methylation of CpG islands is often equated with transcriptional inactivity and there is overwhelming evidence that this is the case for islands located in gene promoters. Such methylation is probably part of a mechanism to permanently silence the activities of genes, including those on the inactive X chromosome. Not all CpG islands and methylation
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